Exploring the Relationship Between Gingivitis and Hypothyroidism in Children

Gingivitis and Hypothyroidism in Children


  • Andisheh Amini Department of Pediatrics, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
  • Pouria Farahani Shahid Beheshti University of Medical Science, Faculty of Dentistry, Tehran, Iran
  • Mahsa Etemadi Department of Periodontology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  • Pardis Khoshnood Department of Restorative Dentistry, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Asieh Mozaffari Department of Periodontics, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
  • Bahareh Sanaee Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran


Periodontitis common oral health problem for children, which involves the inflammation of gum tissue. Hypothyroidism, which is a systemic disorder characterized by the decrease in thyroid hormone levels, has its patients suffering from many dysfunctions in the body. In spite of the fact that they apparently belong to distinct spheres, recent research looks suspiciously for a probable correlation between the two diseases, i.e. gingivitis and hypothyroidism. This paper is a comprehensive narrative review that focuses on explaining the unique relationship between these two conditions in children as it relates to the mechanisms, clinical manifestations, diagnostic difficulties, and therapeutic approaches. Through the process of literature review syntheses, previously unknown interrelations between hypothyroidism and gingival health are discovered. Therefore, the multidisciplinary approach may be one of the factors that improve the overall condition of the patients with these comorbidities as well as the effectiveness of the treatment due to the partnership through the cooperation between dental and endocrine specialists.



Erdem MG, Unlu O, Ates F, Karis D, Demirci M. Oral Microbiota Signatures in the Pathogenesis of Euthyroid Hashimoto’s Thyroiditis. Biomedicines. 2023,11(4):1012.

Ay ZY, Tekneci A, Tan A, Işık AR, Pirgon Ö. Periodontal Health Status of Adolescents with Hashimoto Thyroiditis. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2022;13(1):30–9.

Kothiwale S, Panjwani V. Impact of thyroid hormone dysfunction on periodontal disease. J sci soc. 2016;43(1):34.

Morawska K, Maciejczyk M, Zięba S, Popławski Ł, Kita-Popławska A, Krętowski J, et al. Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients. Mediators Inflamm. 2021;2021:3192409.

USHANTHIKA T, GANAPATHY D, SIVAKUMAR M. Prevalence Of Hypothyroidism In Women With Dental Problems. IJPR . 2020;12(sp2):-

Üner DD, Izol BS. The effect of periodontal status on the TSH and FT4 levels. JOHOE. 2024;();-

Aldulaijan HA, Cohen RE, Stellrecht EM, Levine MJ, Yerke LM. Relationship between hypothyroidism and periodontitis: A scoping review. Clin exp dent. 2020;6(1):147–57.

Shostenko A. Immunological characteristics of patients with generalized catarrhal gingivitis. Sci Herit J. 2020;47(2):72–4.

Köhrle J, Frädrich C. Thyroid hormone system disrupting chemicals. BBest Pract Res Clin Endocrinol Meta. 2021;35(5):101562.

Liu X, Xu J, Li S, Wang X, Liu J, Li X. The prevalence of gingivitis and related risk factors in schoolchildren aged 6–12 years old. BMC Oral Health. 2022;22(1):623.

Gare J, Kanoute A, Orsini G, Gonçalves LS, Ali Alshehri F, Bourgeois D, et al. Prevalence, severity of extension, and risk factors of gingivitis in a 3-month pregnant population: a multicenter cross-sectional study. J Clin Med. 2023;12(9):3349.

Li Z, Qiu Y, Fei Y, Xing Z, Zhu J, Su A. Prevalence of and risk factors for hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis. Endocrine. 2020 ;70(2):243–55.

Wilson SA, Stem LA, Bruehlman RD. Hypothyroidism: Diagnosis and treatment. Am Fam Physician. 2021;103(10):605–13.

MANOHAR J, DINESH SS. Periodontal status among patients with hypothyroidism visiting a private dental hospital in chennai. Int J Pharm Res. 2021;13(1).

Khade J, Khade AM, Pantawane S, Phadnaik M, Siddique A, Bandre GR. Severe Chronic Gingivitis in Association With Hypothyroidism and Grade 2 Adenoid Hypertrophy: A Case Report. Cureus. 2023;15(11).

Cuan-Baltazar Y, Soto-Vega E. Microorganisms associated to thyroid autoimmunity. Autoimmun rev. 2020;19(9):102614.

Carlos Fabue L, Jiménez Soriano Y, Sarrión Pérez MG. Dental management of patients with endocrine disorders. J Clin Exp Dent. 2010;2(4):196–203.

Chowdhary Z, Mohan R, Mehrotra S. An unusual association of gingival enlargement with generalized aggressive periodontitis combined with hypothyroidism and plasma cell gingivitis. J Interdiscip Dent.. 2017;7(3):122–4.

Siassipour A, Katz J. Oral mucous membrane pemphigoid associated with hypothyroidism: A retrospective study and a case report. Int. 2017;48(7):569–73.

Güngör Borsöken A, Gursel Surmelıoglu D. The Effect of Saliva and Dental Caries of the Patients with Hashimoto Thyroiditis on Cytokine Levels. Niger J Clin Pract. 2024;27(1):8.

Belstrøm D, Damgaard C, Könönen E, Gürsoy M, Holmstrup P, Gürsoy UK. Salivary cytokine levels in early gingival inflammation. J of Oral Microb. 2017 1;9(1):1364101.

Roberts HM, Yonel Z, Kantarci A, Grant MM, Chapple IL. Impact of gingivitis on circulating neutrophil reactivity and gingival crevicular fluid inflammatory proteins. Int J Environ Res Public Health. 2022;19(10):6339.

De Luca R, Davis PJ, Lin HY, Gionfra F, Percario ZA, Affabris E, et al. Thyroid hormones interaction with immune response, inflammation and non-thyroidal illness syndrome. Front cell dev biol. 2021;8:614030.

Chatzisymeonidou S, Papadopoulos P, Andreadis D, Poulopoulos A. Desquamative gingivitis: Clinical and epidemiological findings in patients from Northern Greece. Balk J Dent Med. 2023;27(3):148–53.

Shcherba V, Krynytska I, Marushchak M, Korda M. The qualitative and quantitative structure of oral microbiocenosis in rats with periodontitis in a setting of hyper- and hypothyroidism. Rom J Diabetes Nutr Metab Dis. 2019;26(3):293–304.

van der Spek AH, Fliers E, Boelen A. Thyroid hormone and deiodination in innate immune cells. Endocrinology. 2021;162(1):bqaa200.

Zhan L, Feng H fang, Liu H qing, Guo L tao, Chen C, Yao X li, et al. Immune checkpoint inhibitors-related thyroid dysfunction: epidemiology, clinical presentation, possible pathogenesis, and management. Front Endo. 2021;12:649863.

Morais A, Resende M, Pereira J. Tireoidite de Hashimoto e Doença Periodontal: Uma Revisão Narrativa. Acta Médica Portuguesa. 2016 Oct 31;29(10):651–7.

Yavropoulou MP, Sfikakis PP, Chrousos GP. Immune System Effects on the Endocrine System. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000

Jaeger M, Sloot YJE, Horst RT, Chu X, Koenen HJPM, Koeken VACM, et al. Thyrotrophin and thyroxine support immune homeostasis in humans. Immunology. 2021;163(2):155–68.





Review Article