Burn Injuries in Patients with Epilepsy: A Retrospective Case Series with Focus on Risk Factors

Epilepsy-related Burn Injuries

Authors

  • Xiong Ziting Department of Dermatology, Chengdu Seventh People’s Hospital, Chengdu, China
  • Li Dan Department of Burn and Plastic Surgery, Chengdu Second People’s Hospital, Chengdu, China
  • Zhou Jianwen Department of Burn and Plastic Surgery, Chengdu Second People’s Hospital, Chengdu, China
  • Huang Zhenjia Department of Burn and Plastic Surgery, Chengdu Second People’s Hospital, Chengdu, China

Keywords:

Epilepsy; Burn Injury; Seizure Frequency; Antiseizure Medications; Injury Severity

Abstract

Background: Burn injuries in patients with epilepsy represent a significant public health issue. This study aimed to investigate the demographic and clinical characteristics, causes, and severity of burn injuries in patients with epilepsy and to explore associations with epilepsy-related factors. Materials and Methods: We conducted a retrospective analysis of 42 patients with epilepsy who sustained burn injuries and were admitted to our hospital between 2015 and 2023. Data on patient demographics, burn type and severity, total body surface area (TBSA), seizure type and frequency, and antiseizure medication (ASM) adherence were collected and analyzed. Results: Among the 42 patients (28 males and 14 females; mean age 35.6 ± 12.1 years), the most common causes of burns were direct flame (38.1%) and hot liquids (28.6%). Most burns occurred at home (78.6%) during daily activities. Generalized tonic-clonic seizures were the most frequent type (59.5%). Patients with frequent seizures (>1/month) and those with poor ASM adherence experienced more severe burns and longer hospital stays (P<0.01). Conclusion: Patients with epilepsy are at increased risk of burn injuries, especially in the context of uncontrolled seizures. Effective seizure management may play a key role in reducing the severity of such injuries and associated complications.

References

Wang Y, Luo L, Li H, Li M, Huang Y, Huang Y, et al. Clinical profile, management and risk factors for seizure-related burn injuries among patients with epilepsy in southwest China. Heliyon. 2024; 10(1):e23908.

https://doi.org/10.1016/j.heliyon.2023.e23908

PMid:38192783 PMCid:PMC10772717

Ziabari S M Z, Mobayen M R, Rimaz S, Nejat D R, Rimaz S. Evaluation of patterns, cause and risk factors of burns in patients with seizure. International Journal of Burns and Trauma. 2022; 12(1): 23.

Bahçe Z Ş, Yiğit E. Burn Injuries in Patients with Epilepsy in Our Region: A10-Year Review. Archives of Epilepsy. 2021; 27(3): 177-182.

https://doi.org/10.14744/epilepsi.2021.47044

Tunnell N C, Corner S E, Roque A D, Kroll J L, Ritz T, Meuret A E. Biobehavioral approach to distinguishing panic symptoms from medical illness. Frontiers in Psychiatry. 2024; 15: 1296569.

https://doi.org/10.3389/fpsyt.2024.1296569

PMid:38779550 PMCid:PMC11109415

Singerman J, Gomez M, Fish J S . Long-term sequelae of low-voltage electrical injury. Journal of burn care & research. 2008; 29(5): 773-777.

https://doi.org/10.1097/BCR.0b013e318184815d

PMid:18695615

Keshavarzi A, Rahgozar Z, Mortazavi M, Dehghani A. Epidemiology, geographical distribution, and outcome analysis of patients with electrical burns referred to Shiraz Burn Center, Shiraz, Iran during 2008-2019. World journal of plastic surgery. 2022; 11(2): 102.

https://doi.org/10.52547/wjps.11.2.102

PMid:36117901 PMCid:PMC9446130

Mula M. The comorbidities of epilepsy. Academic Press: Ed; 2019.

Johari M G, Mohammadi A A, Dastgerdi V. Burn: a predictable but preventable tragedy in epileptic patients. World Journal of Plastic Surgery. 2019; 8(2): 254.

https://doi.org/10.29252/wjps.8.2.254

PMid:31309065 PMCid:PMC6620804

Akhtar M S, Ahmad I, Khan A H, Khurram M F, Haq A. Burn injury in epileptic patients: an experience in a tertiary institute. Annals of burns and fire disasters. 2014; 27(3): 126.

Lam N N, Duc N M, Nam L. Epilepsy related burn injuries in developing country: an experience in National Burn Hospital. Burns Open. 2019; 3(3): 99-102.

https://doi.org/10.1016/j.burnso.2019.05.003

Shahzad M N, Hussain M, Razi S G, Khan T A, Murtaza I. Burn Injuries in Epileptic Patients: Prevalence, Causes, and Outcomes-A Cross Sectional Study at Pak Italian Burn Center Nishter Hospital Multan. Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University. 2024; 20(4): 683-687.

https://doi.org/10.48036/apims.v20i4.1090

Akhtar M S, Ahmad I, Khan A H, Khurram M F, Haq A. Burn injury in epileptic patients: an experience in a tertiary institute. Annals of burns and fire disasters. 2014; 27(3): 126.

Chang E T, Lin C L, Chen S F, Shen Y C. Risk of burn injury in patients with narcolepsy: a nationwide population-based cohort study. Journal of Burn Care & Research. 2020; 41(3): 663-667.

https://doi.org/10.1093/jbcr/iraa004

PMid:31927592

Johari M G, Mohammadi A A, Dastgerdi V. Burn: a predictable but preventable tragedy in epileptic patients. World Journal of Plastic Surgery. 2019; 8(2): 254.

https://doi.org/10.29252/wjps.8.2.254

PMid:31309065 PMCid:PMC6620804

Lin W J, Harnod T, Lin C L, Kao C H. Mortality risk and risk factors in patients with posttraumatic epilepsy: a population-based cohort study. International journal of environmental research and public health. 2019; 16(4): 589.

https://doi.org/10.3390/ijerph16040589

PMid:30781634 PMCid:PMC6406809

Gragnani A, Müller B R, Oliveira A F, Ferreira L M . Burns and epilepsy-review and case report. Burns. 2015; 41(2): e15-e18.

https://doi.org/10.1016/j.burns.2014.08.004

PMid:25440855

Mabrouk A, Hammad M R, Mabrouk A, Badawy M S. Epilepsy as a cause of burns: our experience in Ain Shams University burn unit. Journal of Burn Care & Research. 2024; 45(5): 1279-1280.

https://doi.org/10.1093/jbcr/irae045

PMid:38491930

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Published

2025-06-29

How to Cite

Ziting, X., Dan, L., Jianwen, Z., & Zhenjia, H. (2025). Burn Injuries in Patients with Epilepsy: A Retrospective Case Series with Focus on Risk Factors: Epilepsy-related Burn Injuries. Galen Medical Journal, e3880. Retrieved from https://journals.salviapub.com/index.php/gmj/article/view/3880

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Original Article