Interleukin-4 mRNA Expression in Laryngeal Squamous Cell Carcinoma Patients with or without Lymph Node Involvement

Authors

  • Esmael Amirazodi Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz
  • Mahboobeh Razmkhah Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz
  • Mansoureh Jaberipour Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz
  • Ahmad Hosseini Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Bijan Khademi Department of ENT, School of Medicine, Shiraz University of Medical Sciences, Shiraz

DOI:

https://doi.org/10.31661/gmj.v3i1.159

Keywords:

Cancer, Interleukin-4, Lymph Node Metastasis, Larynx, T helper 2

Abstract

Background: Interleukin (IL)-4 is a member of T helper 2 (Th2) axis produced by T-lymphocyte and mast cell. It has been shown that IL-4 expression changes in tumor tissues. The main objective of this study is to investigate the expression of IL-4 mRNA in patients with Laryngeal Squamous Cell Carcinoma (LSCC) with or without lymph node involvement.

Materials and Methods: mRNA expression of IL-4 in LSCC tissues were detected by quantative Real-Time PCR (qRT-PCR). Expression of IL-4 gene was compared between lymph node positive and negative patients with Squamous Cell Carcinoma of Larynx.

Results: No statistically significant association was found in expression of IL-4 between lymph node positive and negative patients.

Conclusion: It seems that IL-4 has no important effect on the involvement of lymph node in LSCC. However, to achieve a definite conclusion more investigations are certainly required.

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Published

2023-12-27

How to Cite

Amirazodi, E., Razmkhah, M., Jaberipour, M., Hosseini, A., & Khademi, B. (2023). Interleukin-4 mRNA Expression in Laryngeal Squamous Cell Carcinoma Patients with or without Lymph Node Involvement. Galen Medical Journal, 3(1), e159. https://doi.org/10.31661/gmj.v3i1.159

Issue

Vol. 3 No. 1 (2014): March 2014

Section

Original Article

License

Copyright (c) 2014 Galen Medical Journal

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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