Blood Level of 2-arachidonoyl Glycerol (2-AG), Neuropeptide Y and Omentin and Their Correlation with Food Habits in Obese Women
DOI:
https://doi.org/10.31661/gmj.v9i.1721Keywords:
Obesity; Omentin; Endocannabinoids; Neuropeptide Y; Feeding Behavior; Fatty AcidsAbstract
Background: Despite growing concern about the increasing global burden of obesity, there are still many uncertainties in understanding the pathogenesis of this disease. This study aimed to investigate the serum levels of 2-arachidonoylglycerol (2-AG), neuropeptide Y (NPY), and omentin, concerning dietary patterns in obese women. Materials and Methods: This case-control study was carried on an equal number of obese (case group) and normal-weight women (n=45 each). Dietary intake was determined based on the food frequency questionnaire. Serum levels of 2-AG, NPY, and omentin were determined using ELISA. Results: The obese group showed significantly higher 2-AG and NPY levels than the controls(P<0.001). There were significant positive correlations between the serum level of 2-AG and calorie intake (r=0.219, P=0.038), carbohydrates (r=0.238, P=0.024), fat (r=0.227, P=0.032), saturated fatty acids (r=0.272, P=0.009), and monounsaturated fatty acids (r=0.265, P=0.012). Conclusion: Our study revealed that dietary patterns, in particular, the type of fatty acids used may influence levels of 2-AG, NPY, and omentin, which all are involved in pathways resulting in obesity.[GMJ.2020;9:e1721]
References
Rippe JM, Angelopoulos TJ. Obesity: Prevention and treatment. CRC Press; 2012 May 11. https://doi.org/10.1201/b12085 Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32(9):1431. https://doi.org/10.1038/ijo.2008.102PMid:18607383 Hall KD, Heymsfield SB, Kemnitz JW, Klein S, Schoeller DA, Speakman JR. Energy balance and its components: implications for body weight regulation. Am J Clin Nutr. 2012 1;95(4):989-94. https://doi.org/10.3945/ajcn.112.036350PMid:22434603 PMCid:PMC3302369 Ge Q, Maury E, Rycken L, Gérard J, Noel L, Detry R, Navez B, Brichard SM. Endocannabinoids regulate adipokine production and the immune balance of omental adipose tissue in human obesity. Int J Obes. 2013;37(6):874. https://doi.org/10.1038/ijo.2012.123PMid:22868830 Nicholson J, Azim S, Rebecchi MJ, Galbavy W, Feng T, Reinsel R, Rizwan S, Fowler CJ, Benveniste H, Kaczocha M. Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. PLoS One. 2015;10(4):e0123132. https://doi.org/10.1371/journal.pone.0123132PMid:25835291 PMCid:PMC4383333 Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci. 2005;8(5):585. https://doi.org/10.1038/nn1457PMid:15856067 Matias I, Belluomo I, Cota D. The fat side of the endocannabinoid system: role of endocannabinoids in the adipocyte. Cannabis Cannabinoid Res. 2016;1(1):176-85. https://doi.org/10.1089/can.2016.0014 van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MC, Fliers E, Kalsbeek A, et al. Neuropeptide Y and leptin sensitivity is dependent on diet composition. J Neuroendocrinol. 2014;26(6):377-85. https://doi.org/10.1111/jne.12155PMid:24698502 Vähätalo LH, Ruohonen ST, Mäkelä S, Ailanen L, Penttinen AM, Stormi T, et al. Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons. Nutr Diabetes. 2015;5(4):e151. https://doi.org/10.1038/nutd.2015.1PMid:25915740 PMCid:PMC4423197 Van den Heuvel JK, Furman K, Gumbs MC, Eggels L, Opland DM, Land BB, et al. Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. Biol Psychiatry. 2015;77(7):633-41. https://doi.org/10.1016/j.biopsych.2014.06.008PMid:25109664 PMCid:PMC4295932 Naughton SS, Mathai ML, Hryciw DH, McAinch AJ. Fatty acid modulation of the endocannabinoid system and the effect on food intake and metabolism. Int J Endocrinol. 2013;2013. https://doi.org/10.1155/2013/361895PMid:23762050 PMCid:PMC3677644 Jager G, Witkamp RF. The endocannabinoid system and appetite: relevance for food reward. Nutr Res Rev. 2014;27(1):172-85. https://doi.org/10.1017/S0954422414000080PMid:24933167 Yao XG, Yan ZT, Li NF, Wang YC, Li T, Zhu J, et al. Serum neuropeptide Y level in hypertensive patients with obstructive sleep apnea syndrome. Zhonghua Xin Xue Guan Bing Za Zhi. 2010;38(6):510-3. Sitticharoon C, Chatree S, Churintaraphan M. Expressions of neuropeptide Y and Y1 receptor in subcutaneous and visceral fat tissues in normal weight and obese humans and their correlations with clinical parameters and peripheral metabolic factors. Regul Pept. 2013; 185:65-72. https://doi.org/10.1016/j.regpep.2013.06.015PMid:23838112 Cote M, Matias I, Lemieux I, Petrosino S, Almeras N, Despres JP, et al. Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. Int J Obes. 2007;31(4):692. https://doi.org/10.1038/sj.ijo.0803539PMid:17224929 Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 2001;410(6830):822-5. https://doi.org/10.1038/35071088PMid:11298451 Artmann A, Petersen G, Hellgren LI, Boberg J, Skonberg C, Nellemann C, et al. Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. Biochim Biophys Acta Mol Cell Biol Lipids. 2008;1781(4):200-12. https://doi.org/10.1016/j.bbalip.2008.01.006PMid:18316044 Kim J, Carlson ME, Kuchel GA, Newman JW, Watkins BA. Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice. Int J Obes. 2016;40(1):129. https://doi.org/10.1038/ijo.2015.135PMid:26219414 PMCid:PMC4722239 Kabiri A, Hosseinzadeh-Attar MJ, Haghighatdoost F, Eshraghian M, Esmaillzadeh A. Impact of olive oil-rich diet on serum omentin and adiponectin levels: a randomized cross-over clinical trial among overweight women. Int J Food Sci Nutr. 2017;68(5):560-8. https://doi.org/10.1080/09637486.2016.1261808PMid:27931137 Huang XF, Xin X, McLennan P, Storlien L. Role of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression. Diabetes Obes Metab. 2004;6(1):35-44. https://doi.org/10.1111/j.1463-1326.2004.00312.xPMid:14686961 Lam TK, Schwartz GJ, Rossetti L. Hypothalamic sensing of fatty acids. Nat Neurosci. 2005;8(5):579. https://doi.org/10.1038/nn1456PMid:15856066 De Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes. 2007;56(6):1655-61. https://doi.org/10.2337/db06-1506PMid:17329619 Oswiecimska J, Suwala A, Swietochowska E, Ostrowska Z, Gorczyca P, Ziora-Jakutowicz K, et al. Serum omentin levels in adolescent girls with anorexia nervosa and obesity. Physiol Res. 2015 ;64(5):701 https://doi.org/10.33549/physiolres.932841PMid:25804090 Auguet T, Quintero Y, Riesco D, Morancho B, Terra X, Crescenti A, et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Med Genet. 2011;12(1):60 https://doi.org/10.1186/1471-2350-12-60PMid:21526992 PMCid:PMC3107780 Wilms B, Ernst B, Gerig R, Schultes B. Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training. Exp Clin Endocrinol Diabetes. 2015;123(03):187-92. https://doi.org/10.1055/s-0034-1398504PMid:25789872 Tan BK, Adya R, Farhatullah S, Chen J, Lehnert H, Randeva HS. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome. Diabetes. 2010;59(12):3023-31. https://doi.org/10.2337/db10-0124PMid:20852028 PMCid:PMC2992762
