The Fasa Registry on Systolic Heart Failure (FaRSH): Feasibility Study and the First 5-year Reports
DOI:
https://doi.org/10.31661/gmj.v10i.2111Keywords:
Heart Failure, Systolic, Registry, IranAbstract
Background: The literature on patients with heart failure (HF) from the Middle East, besides a few existing registries, is scarce. We report, for the first time in our country, a hospital-based registry for systolic HF. Materials and Methods: This was a web-based registry on HF, conducted in Vali-Asr Hospital affiliated with Fasa University of Medical Sciences, Fasa, Iran. The goal of this registry was to define overall baseline clinical characteristics and natural history of hospitalized patients with systolic HF, to evaluate current management schema and implementation of practice guidelines, and to determine the correlation between genetic predisposition environmental effects, individuals’ characteristics of health, lifestyle, morbidity, and mortality in relation with the effects of medication. Results: To date, 2378 individuals with a mean of age 67.08±13.07 years have been registered. Among which, 1381 (58.07%) patients were diagnosed with denovo HF. Most of the patients (60.1%) were male, and 8.9% had admissions during the past 30 days. The most common causes of HF were ischemic heart disease (86.5%) and hypertension (5.3%). Most patients had NYHA class one (44.3%) and three (20.4%). Overall, near 30% had diabetes and more than 38% had hyperlipidemia. Most individuals have been not a history of cigarette smoking (68.7%) or water-pipe smoking (96.9%). Also, 22.2% were current opium users, and 3.2% were previous opium users. Conclusions: The findings of this registry could make a realistic view of HF as a chronic disease with a burden. Therefore, policymakers can design programs and guidelines to prevent disease and better survival and quality of life. [GMJ.2021;10:e2111]
References
Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014;63(12):1123-33. https://doi.org/10.1016/j.jacc.2013.11.053PMid:24491689 Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129-200. https://doi.org/10.1093/eurheartj/ehw128PMid:27206819 Adams KF, Jr., Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149(2):209-16. https://doi.org/10.1016/j.ahj.2004.08.005PMid:15846257 Fonarow GC, Abraham WT, Albert NM, Gattis WA, Gheorghiade M, Greenberg B, et al. Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): rationale and design. Am Heart J. 2004;148(1):43-51. https://doi.org/10.1016/j.ahj.2004.03.004PMid:15215791 Rajadurai J, Tse H-F, Wang C-H, Yang N-I, Zhou J, Sim D. Understanding the epidemiology of heart failure to improve management practices: an Asia-Pacific perspective. J Card Fail. 2017;23(4):327-9. https://doi.org/10.1016/j.cardfail.2017.01.004PMid:28111226 Djoussé L, Driver JA, Gaziano JM. Relation between modifiable lifestyle factors and lifetime risk of heart failure. JAMA. 2009;302(4):394-400. https://doi.org/10.1001/jama.2009.1062PMid:19622818 PMCid:PMC2742484 Okura Y, Ramadan MM, Ohno Y, Mitsuma W, Tanaka K, Ito M, et al. Impending epidemic: future projection of heart failure in Japan to the year 2055. Circ J. 2008;72(3):489-91. https://doi.org/10.1253/circj.72.489PMid:18296852 Bonneux L, Barendregt JJ, Meeter K, Bonsel GJ, van der Maas PJ. Estimating clinical morbidity due to ischemic heart disease and congestive heart failure: the future rise of heart failure. Am J Public Health. 1994;84(1):20-8. https://doi.org/10.2105/AJPH.84.1.20PMid:8279606 PMCid:PMC1614906 http://www.cdc.gov/nchs/icd.htm; Bahramali E, Askari A, Zakeri H, Farjam M, Dehghan A, Zendehdel K. Fasa Registry on Acute Myocardial Infarction (FaRMI): Feasibility Study and Pilot Phase Results. PloS one. 2016;11(12):e0167579. https://doi.org/10.1371/journal.pone.0167579PMid:27907128 PMCid:PMC5132161 Pezeshki B, Karimi A, Ansari A, Yazdanpanah MH, Elmi M, Farjam M, et al. Fasa Registry on Diabetes Mellitus (FaRD): Feasibility Study and Pilot Phase Results. GMJ. 2021;10:e2137. https://doi.org/10.31661/gmj.v10i0.2137 Naghavi M, Shahraz S, Sepanlou SG, Dicker D, Naghavi P, Pourmalek F, et al. Health transition in Iran toward chronic diseases based on results of Global Burden of Disease 2010. Arch Iran Med. 2014;17(5):321-35. Yazdanpanah MH, Homayounfar R, Khademi A, Zarei F, Shahidi A, Farjam M. Short sleep is associated with higher prevalence and increased predicted risk of cardiovascular diseases in an Iranian population: Fasa PERSIAN Cohort Study. Sci Rep. 2020;10(1):1-13. https://doi.org/10.1038/s41598-020-61506-0PMid:32165672 PMCid:PMC7067883 Sato N, Kajimoto K, Asai K, Mizuno M, Minami Y, Nagashima M, et al. Acute decompensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: rationale, design, and preliminary data. Am Heart J. 2010;159(6):949-55. https://doi.org/10.1016/j.ahj.2010.03.019PMid:20569705 Lam CS, Teng T-HK, Tay WT, Anand I, Zhang S, Shimizu W, et al. Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry. Eur Heart J. 2016;37(41):3141-53. https://doi.org/10.1093/eurheartj/ehw331PMid:27502121 Liu X, Yu H, Pei J, Chu J, Pu J, Zhang S. Clinical characteristics and long-term prognosis in patients with chronic heart failure and reduced ejection fraction in China. Heart Lung Circ. 2014;23(9):818-26. https://doi.org/10.1016/j.hlc.2014.02.022PMid:24881031 Yu SB, Cui HY, Qin M, Kong B, Liu T, Zhao QY, et al. [Characteristics of in-hospital patients with chronic heart failure in Hubei province from 2000 to 2010]. Zhonghua xin xue guan bing za zhi. 2011;39(6):549-52. Mao C-T, Liu M-H, Hsu K-H, Fu T-C, Wang J-S, Huang Y-Y, et al. Effect of multidisciplinary disease management for hospitalized heart failure under a national health insurance programme. J Cardiovasc Med (Hagerstown). 2015;16(9):616-24. https://doi.org/10.2459/JCM.0000000000000089PMid:25105284 Wang C-C, Chang H-Y, Yin W-H, Wu Y-W, Chu P-H, Wu C-C, et al. TSOC-HFrEF Registry: A Registry of Hospitalized Patients with Decompensated Systolic Heart Failure: Description of Population and Management. Acta Cardiol Sin. 2016;32(4):400-11. Youn YJ, Yoo B-S, Lee J-W, Kim J-Y, Han SW, Jeon E-S, et al. Treatment performance measures affect clinical outcomes in patients with acute systolic heart failure. Circ J. 2012;76(5):1151-8. https://doi.org/10.1253/circj.CJ-11-1093PMid:22343195 Zubaid M, Rashed WA, Al-Khaja N, Almahmeed W, Al-Lawati J, Sulaiman K, et al. Clinical presentation and outcomes of acute coronary syndromes in the gulf registry of acute coronary events (Gulf RACE). Saudi Med J. 2008;29(2):251-5. Sulaiman KJ, Panduranga P, Al-Zakwani I, Alsheikh-Ali A, Al-Habib K, Al-Suwaidi J, et al. Rationale, Design, Methodology and Hospital Characteristics of the First Gulf Acute Heart Failure Registry (Gulf CARE). Heart views. 2014;15(1):6-12. https://doi.org/10.4103/1995-705X.132137PMid:24949181 PMCid:PMC4062990 AlHabib KF, Elasfar AA, AlBackr H, AlFaleh H, Hersi A, AlShaer F et al. Design and preliminary results of the heart function assessment registry trial in Saudi Arabia (HEARTS) in patients with acute and chronic heart failure. Eur J Heart Fail. 2011;13(11):1178-84. https://doi.org/10.1093/eurjhf/hfr111PMid:21873337 Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola V-P, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27(22):2725-36. https://doi.org/10.1093/eurheartj/ehl193PMid:17000631 Jonsson Ã…, Edner M, Alehagen U, Dahlström U. Heart failure registry: a valuable tool for improving the management of patients with heart failure. Eur J Heart Fail. 2010;12(1):25-31. https://doi.org/10.1093/eurjhf/hfp175PMid:20023041 Yancy CW, Fonarow GC. Quality of care and outcomes in acute decompensated heart failure: The ADHERE Registry. Curr Heart Fail Rep. 2004;1(3):121-8. https://doi.org/10.1007/s11897-004-0021-8PMid:16036035 Sulaiman K, Panduranga P, Al-Zakwani I, Alsheikh-Ali AA, AlHabib KF, Al-Suwaidi J et al. Clinical characteristics, management, and outcomes of acute heart failure patients: observations from the Gulf acute heart failure registry (Gulf CARE). Eur J Heart Fail. 2015;17(4):374-84. https://doi.org/10.1002/ejhf.245PMid:25739882 AlHabib KF, Elasfar AA, AlBackr H, AlFaleh H, Hersi A, AlShaer F, et al. Design and preliminary results of the heart function assessment registry trial in Saudi Arabia (HEARTS) in patients with acute and chronic heart failure. Eur J Heart Fail. 2011;13(11):1178-84. https://doi.org/10.1093/eurjhf/hfr111PMid:21873337 Yazdanpanah MH, Sayyadipoor S, Hojati SR, Nikmanesh A, Farjam M, Homayounfar R. The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study. Diabetes Metab Syndr Obes. 2020;13:2975. https://doi.org/10.2147/DMSO.S263093PMid:32943893 PMCid:PMC7467662 Yazdanpanah MH, Bahramali E, Naghizadeh MM, Farjam M, Mobasheri M, Dadvand S. Different body parts' fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study. BMC Cardiovasc Disord. 2021;21(1):1-11. https://doi.org/10.1186/s12872-021-02095-2PMid:34090333 PMCid:PMC8178852 Schultz JE, Gross GJ. Opioids and cardioprotection. Pharmacol Ther. 2001;89(2):123-37. https://doi.org/10.1016/S0163-7258(00)00106-6 Misra P, Caldito GC, Kakkar AK, Mancini MC, Reddy PC. Outcomes of coronary artery bypass grafting in patients with a history of illicit drug use. Am J Cardiol. 2003;92(5):593-5. https://doi.org/10.1016/S0002-9149(03)00730-6 Aghadavoudi O, Eizadi-Mood N, Najarzadegan MR. Comparing cardiovascular factors in opium abusers and non-users candidate for coronary artery bypass graft surgery. Adv Biomed Res. 2015;4:12. https://doi.org/10.4103/2277-9175.148294PMid:25625118 PMCid:PMC4300596 Sulaiman K, Panduranga P, Alâ€Zakwani I, Alsheikhâ€Ali AA, AlHabib KF, Alâ€Suwaidi J, et al. Clinical characteristics, management, and outcomes of acute heart failure patients: observations from the Gulf acute heart failure registry (Gulf CARE). Eur J Heart Fail. 2015;17(4):374-84. https://doi.org/10.1002/ejhf.245PMid:25739882
