Mesenchymal Stromal/Stem Cells in the Tumor Microenvironment and Their Role in Tumor Progression

Authors

  • Hossein Kargar Jahromi Research Center for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran; Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran
  • Venus Shahabi Raberi Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  • Samira Abdollahi Moghadam
  • Maryam Poudineh School of Medicine, Mashhad Azad University, Mashhad, Iran
  • Behnaz Barghgir School of Medicine, Shahrud University, Shahrud, Iran
  • Maryam Molaee Eshgh Abad School of Medicine, Shahrud University, Shahrud, Iran
  • Morteza Jafarinia Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ensieh Sharafi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

DOI:

https://doi.org/10.31661/gmj.v11i.2637

Keywords:

Mesenchymal Stromal Cells, Tumor Microenvironment, Cancer, Tumor, Mesenchymal Stem Cells

Abstract

Mesenchymal stromal/stem cells (MSCs) are a source of stem cells that can be easily harvested and differentiated into numerous cells. Over the past few decades, these cells have been introduced as promising therapeutic candidates for different diseases. Different studies have shown the role of these cells in regenerative medicine. Tumor growth is correlated with the interactions between MSCs and tumor cells in the tumor microenvironment. The precise key role played by MSCs in the progression of tumors is under question, and the effect of MSCs on the tumor is controversial it might involve the development of tumor initiation or prevent the spread of already existing ones. In this study, we reviewed the role of MSCs in the tumor microenvironment and their influence on promoting or inhibiting tumor progression.

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Published

2022-12-25

Issue

Vol. 11 (2022): 2022

Section

Review Article

License

https://creativecommons.org/licenses/by/4.0/