Postoperative Delirium and Dementia in Patients Undergoing Cardiac Surgery: A Review of Randomized Controlled Trials

Postoperative Dementia and Cardiac Surgery


  • Venus Shahabi Raberi Seyed-Al-Shohada cardiology Hospital, Urmia University of Medical Sciences, Urmia, Iran
  • Morteza Solati Kooshk Qazi School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ali Zolfi gol Department of Pediatric Cardiology, Shahid Motahari Hospital, Hospital, Urmia University of Medical Sciences, Urmia, Iran
  • Rahil GhorbaniNia Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  • Ozra Kahourian Seyed-Al-Shohada cardiology Hospital, Urmia University of Medical Sciences, Urmia, Iran
  • Reza Faramarz Zadeh Seyed-Al-Shohada cardiology Hospital, Urmia University of Medical Sciences, Urmia, Iran



Cardiac Surgery, Postoperative Complications, Dementia


Delirium and dementia are considered to be the most significant postoperative neurocognitive complications in patients undergoing cardiac surgery, particularly those aged 60 years and older, which reduces the post-surgery quality of life, prolongs hospitalization, increases costs, and ele-vated the rates of mortality. Nevertheless, the etiology, risk factors, and predictive biomarkers, have not been well elucidated particularly, in patients with unmanifested underline cognitive im-pairments. The present study aimed to review the findings on the etiology, factors increasing the risk of incidence, and predictive biomarkers of postoperative delirium and dementia after cardiac surgery, and to describe the suggested pharmacological and non-pharmacological interventions.


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