The Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in Rheumatoid Arthritis

Mesenchymal Stem Cells and Extracellular Vesicles in Rheumatoid Arthritis


  • Amir Abaszadeh School of Medicine , Ilam University, Ilam, Iran
  • Oveis Salehi Tehran University of Medical Sciences, Tehran, Iran
  • Ahmadreza Badali Tabriz University of Medical Sciences, Research Center for Connective Tissue Diseases
  • Dorsa Javanmardi Fars Stem Cell Research Institute, Shiraz, Fars, Iran
  • Alireza Sarlak Student Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Azam Lotfalian Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Maryam Poudineh School of Medicine, Mashhad Azad University, Mashhad, Iran


Rheumatoid Arthritis; Mesenchymal Stem Cell; Extracellular Vesicle; Exosome


There is presently no cure for the chronic inflammatory disease rheumatoid arthritis (RA), which affects the joints and other organs. Mesenchymal stem/stromal cells (MSCs) are adult stem cells that are widely studied in inflammatory diseases. Several studies have shown the therapeutic effects of MSCs in preclinical and clinical RA. However, there are a few concerns regarding the use of MSCs, such as immune rejection and malignancy. Since MSCs exert their potential effects in a paracrine manner, more attention has been paid to their extracellular vesicles (MSC-EVs). In the current study, we reviewed the application of MSCs and their EVs in RA. A better understanding of the mechanisms driving MSC and MSC-EVs in RA offers insight into possible treatment options for RA.


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