Prevalence of Type 2 Diabetes Mellitus and Dyslipidemia in Patients with Cryptogenic Cirrhosis: a Hospital-Based Study

Abstract

Background: Liver cirrhosis is the end stage of liver disease that is caused by various etiologies. Type 2 diabetes mellitus (T2DM), dyslipidemia and obesity are the most common situations that are seen together with non-alcoholic steatohepatitis (NASH), which is frequently asymptomatic and can silently lead to cirrhosis. There are some studies suggesting that NASH might be one of the underlying causes of cryptogenic cirrhosis (CC). Materials and Methods: Two hundred twenty six cirrhotic patients registered in transplantation unit of Namazi Hospital of Shiraz University of Medical Sciences from January 2006 to the last day of June 2014 were selected in two groups of CC and non-CC patients. Age, sex, weight, child class of cirrhosis and presence of T2DM, dyslipidemia and lipid profile were extracted from their records. Results: There was significant difference between prevalence of T2DM and FBS levels among CC and non-CC subjects (P <0.01). Prevalence of T2DM in CC group (38.9%) was more than two times higher than non-CC group (18.6%). On the contrary, the differences between prevalence of dyslipidemia and its laboratory characteristics such as total cholesterol, TG, HDL and LDL were insignificant among both groups (P >0.05). Conclusion: Results showed a higher prevalence of T2DM in subjects with CC but there are some doubts about T2DM being one of the risk factors of CC. Dyslipidemia and its components including TG, LDL, HDL and total cholesterol were not significantly different in CC and non-CC subjects.[GMJ. 2015;4(3):112-16]