Probiotics: Potential Benefits and Safety in Hematological Malignancies

Probiotics in Hematologic Cancers


  • Mahdiyar Iravani Saadi Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mani Ramzi 1-Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran/ 2-Hematology, Oncology and Bone Marrow Transplantation Department, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nastaran Fooladivanda Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Sholeh Afshinpour Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Zahra Ghahramani Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Maryam Ahmadyan Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nadiya Kheradmand Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nadiya Kheradmand Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Hourvash Haghighinejad Family Medicine Department, Shiraz University of Medical Sciences, Shiraz, Iran
  • Zahra Rahimian Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


Probiotics; Hematologic Malignancy; Chemotherapy; Radiation Therapy; Hematopoietic Stem Cell Transplantation; HSCT; GVHD


Cancer remains one of the most significant global health challenges, with increasing incidence and mortality rates and a substantial socioeconomic burden. Traditional cancer treatments such as chemotherapeutic drugs and radiation therapies, while effective, have significant adverse effects on the body, prompting the search for less invasive treatment options. In recent years, probiotics have emerged as a promising alternative in the prevention and treatment of cancer and its associated complications, especially in gastrointestinal malignancies. Probiotics have been found to have several beneficial effects on the body, including the ability to mitigate the gastrointestinal side effects of cancer treatments by restoring gut microbiota balance and improving intestinal barrier function. By reducing inflammation and enhancing the immune response, probiotics can also help alleviate other cancer-related symptoms and improve the overall well-being of cancer patients. Despite their potential benefits, the efficacy and safety of probiotics in immunocompromised patients remain uncertain, and caution must be exercised during their administration. Further research is needed to determine the optimal clinical use, safety, and efficacy of probiotics in cancer treatment.


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