Serum Calcium and Magnesium Levels in Women Presenting with Pre-eclampsia: A Systematic Review and Meta-analysis Based on Observational Studies: Serum Calcium and Magnesium Levels in Women with Pre-eclampsia

Serum Calcium and Magnesium Levels in Women with Pre-eclampsia

Authors

  • Arqavan Eslamzadeh Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
  • Seyyed Mohammad amin Kashani Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nasrin Asadi Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Sina Bazmi Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
  • Shahla Rezaei Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  • Zeinab Karimimoghadam Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  • Peyman Nowrouzi-Sohrabi Razi Herbal Medicines Research Center, Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Reza Tabrizi 1. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; 2. Universal Scientific Education and Research Network Office, Fasa University of Medical Sciences, Fasa, Iran; 3. Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran

DOI:

https://doi.org/10.31661/gmj.v12i.3151

Keywords:

Calcium, Female, Humans, Magnesium, Pre-eclampsia, Pregnancy

Abstract

Background: Multiple studies have investigated the serum concentrations of calcium (Ca) and magnesium (Mg) in preeclampsia, but the results have been contradictory. The objective of this systematic review and meta-analysis was to examine the association between serum calcium and magnesium levels in patients with preeclampsia and those in the healthy pregnancies. Materials and Methods: A comprehensive search was conducted in various online databases, including PubMed/Medline, Scopus, Embase, Web of Sciences, and Cochrane library to identify relevant studies on Ca and Mg levels in preeclampsia up to July 2023. Inter-study heterogeneity across the included studies was assessed using the chi-square test and I2 statistic. Pooled effect size (ES) was calculated as weighted mean differences (WMDs) with corresponding 95% confidence intervals (CI). Results: A total of 76 articles (comprising 92 studies) were included, with a combined sample size of 10,482 participants (preeclampsia: n=3,991; controls: n=6,491). The random-effects model revealed significantly lower levels of calcium (WMD=-0.807 mg/dL, 95% CI: -0.983, -0.632, P<0.01) and magnesium (WMD=-0.215, 95% CI: -0.338, -0.092, P<0.01) in women with pre-eclampsia compared to the control group. However, the overall pooled WMD for calcium and magnesium levels did not significantly change when individual studies were excluded one by one. Conclusion: This meta-analysis demonstrates that the circulating levels of calcium and magnesium in patients with preeclampsia are significantly lower than those in the control group.

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Published

2023-12-18

How to Cite

Eslamzadeh, A., Kashani, S. M. amin ., Asadi, N., Bazmi, S. ., Rezaei, S. ., Karimimoghadam, Z. ., … Tabrizi, R. (2023). Serum Calcium and Magnesium Levels in Women Presenting with Pre-eclampsia: A Systematic Review and Meta-analysis Based on Observational Studies: Serum Calcium and Magnesium Levels in Women with Pre-eclampsia: Serum Calcium and Magnesium Levels in Women with Pre-eclampsia. Galen Medical Journal, 12, e3151. https://doi.org/10.31661/gmj.v12i.3151

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Vol. 12 (2023): 2023

Section

Review Article

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