Introduction of HER-2 and a Short Review on Its Role in Prognosis and Treatment of Breast Cancer

Authors

  • Seyed Abbas Mirmalek Department of Surgery, Islamic Azad University, Tehran Medical Sciences Branch, Tehran
  • Fatemeh Elhamkani Tehran University of Medical Sciences and Health Services, Shariati Hospital, Tehran
  • Seyed Alireza Salimi Tabatabaee
  • Hossein Mahmoodzadeh Tehran University of Medical Sciences and Health Services, Shariati Hospital, Tehran
  • Yekta Parsa
  • Soheila Yadollah-Damavandi
  • Ehsan Jangholi Young Researchers Club, Islamic Azad University, Tehran Medical Sciences Branch, Tehran

DOI:

https://doi.org/10.31661/gmj.v3i3.318

Keywords:

Breast Cancer, Human Epidermal growth factor Receptor-2, Prognosis, HER-2, Review

Abstract

Human Epidermal growth factor Receptor-2 (HER-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. About 280 articles were reviewed and 115 were referred in this review article on HER-2. HER-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. Overexpression results in aggressive behavior, early metastasis to lymph nodes and distant areas, and poor prognosis in breast cancer. HER-2 seems to be a prognostic and predictive factor and must be considered in all breast cancer cases.

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Published

2014-09-01

Issue

Vol. 3 No. 3 (2014): September 2014

Section

Review Article

License

https://creativecommons.org/licenses/by/4.0/