Exploring Traditional and Complementary Medicine Approaches for Fractured Bones: A Systematic Review
Traditional and Complementary Medicine for Fractured Bones
Keywords:
Bone Fracture; Traditional Medicine; Complementary Medicine; Traditional Persian Medicine; Systematic ReviewAbstract
Background: The objective of this review is to provide a comprehensive summary of published clinical studies that have examined the effects of different traditional and complementary medicine (TACM) interventions on patients with various types of bone fractures. Materials and Methods: A systematic search was conducted in major databases including Web of Science, PubMed, Cochrane library, and Scopus. The search encompassed studies published from the inception of these databases until October 20, 2023. The inclusion criteria encompassed original research papers that evaluated the outcomes of patients with any type of bone fracture who received TACM interventions. Results: Out of the initial 952 search results, a total of six papers met the eligibility criteria and were included in this review. Among these, four studies focused on biologically-based TACM interventions, primarily herbal formulations. The remaining two studies examined energy-based TACM, specifically auricular acupressure and electromagnetic intervention. Conclusion: The findings of this review suggest that the studied TACM modalities demonstrate promising efficacy and safety for patients with fractured bone. However, it is important to note that most of the included studies had limitations in terms of small sample sizes and short follow-up durations.
References
Holloway KL, Brennan SL, Kotowicz MA, Bucki-Smith G, Dobbins AG, Timney EN et al. Age-and sex-related patterns of first fracture and fracture prevalence. Calcif Tissue Int. 2015;96(1):38-44.
https://doi.org/10.1007/s00223-014-9936-6
PMid:25467009
Pressley JC, Kendig TD, Frencher SK, Barlow B, Quitel L, Waqar F. The epidemiology of bone fracture across the age span in blacks and whites. J Trauma. 2011;71(5 Suppl 2):S541.
https://doi.org/10.1097/TA.0b013e31823a4d58
PMid:22072044 PMCid:PMC3274822
Court-Brown CM, Caesar B. Epidemiology of adult fractures: a review. Injury. 2006;37(8):691-7.
https://doi.org/10.1016/j.injury.2006.04.130
PMid:16814787
Geris L, Gerisch A, Vander Sloten J, Weiner R, Van Oosterwyck H. Angiogenesis in bone fracture healing: a bioregulatory model. J Theor Biol. 2008;251(1):137-58.
https://doi.org/10.1016/j.jtbi.2007.11.008
PMid:18155732
Fazzalari N. Bone fracture and bone fracture repair. Osteoporos Int. 2011;22(6):2003-6.
https://doi.org/10.1007/s00198-011-1611-4
PMid:21523400
Jain AK. The rational treatment of fractures: Use the evidence with caution. Indian J Orthop. 2011;45(2):101.
https://doi.org/10.4103/0019-5413.77125
PMid:21430860 PMCid:PMC3051112
Eiff MP, Hatch RL. Fracture Management for Primary Care. E-Book: Elsevier Health Sciences; 2011.
Wehner T, Claes L, Niemeyer F, Nolte D, Simon U. Influence of the fixation stability on the healing time-a numerical study of a patient-specific fracture healing process. Clin Biomech. 2010;25(6):606-12.
https://doi.org/10.1016/j.clinbiomech.2010.03.003
PMid:20452105
Einhorn TA, Gerstenfeld LC. Fracture healing: mechanisms and interventions. Nat Rev Rheumatol. 2015;11(1):45-54.
https://doi.org/10.1038/nrrheum.2014.164
PMid:25266456 PMCid:PMC4464690
Baht GS, Vi L, Alman BA. The role of the immune cells in fracture healing. Curr Osteoporos Rep. 2018;16:138-45.
https://doi.org/10.1007/s11914-018-0423-2
PMid:29508143 PMCid:PMC5866272
El-Jawhari JJ, Jones E, Giannoudis PV. The roles of immune cells in bone healing; what we know, do not know and future perspectives. Injury. 2016;47(11):2399-406.
https://doi.org/10.1016/j.injury.2016.10.008
PMid:27809990
Giganti MG, Tresoldi I, Masuelli L, Modesti A, Grosso G, Liuni FM et al. Fracture healing: from basic science to role of nutrition. Front Biosci (Landmark Ed). 2014;19(7):1162-75.
PMid:24896342
Kasnavieh SMH, Sadeghi SMH, Khameneh SMH, Khodadoost M, Bazrafshan A, Kamalinejad M et al. Dietary recommendations in fracture healing in traditional persian medicine: a historical review of literature. J Evid Based Complementary Altern Med. 2017;22(3):513-7.
https://doi.org/10.1177/2156587216685509
PMid:30208734 PMCid:PMC5871169
Wang M, Bao Z, Zhao N. Classification and reduction manipulation of fractures in Chinese traditional Mongolian osteopathy. J Tradit Chin Med. 2014;34(1):122-6.
https://doi.org/10.1016/S0254-6272(14)60065-0
PMid:25102702
Liao H-H, Yeh C-C, Lin C-C, Chen B-C, Yeh M-H, Chang K-M et al. Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: a nationwide population-based study. J Ethnopharmacol. 2015;173:11-9.
https://doi.org/10.1016/j.jep.2015.07.014
PMid:26187277
Tseng CY, Huang CW, Huang HC, Tseng WC. Utilization pattern of traditional Chinese medicine among fracture patients: a Taiwan hospital-based cross-sectional study. Evid Based Complement Alternat Med. 2018;2018:1706517.
https://doi.org/10.1155/2018/1706517
PMid:30363858 PMCid:PMC6186335
Sprague S, Lutz K, Bryant D, Farrokhyar F, Zlowodzki M, Bhandari M. Complementary and alternative medicine use in patients with fractures. Clin Orthop Relat Res. 2007;463:173-8.
https://doi.org/10.1097/BLO.0b013e3181513e74
PMid:17960679
Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, Hosseini Kasnavieh SM, Kamalinejad M, Gachkar L et al. Efficacy of Momiai in Tibia fracture repair: a randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med. 2020;26(6):521-8.
https://doi.org/10.1089/acm.2019.0453
PMid:32310691
Ram KS, Ali I, Puneet W, Anup G, Kumar A, Harsha P. Effects of Ayurvedic medicines in the healing and control of infection in jaw fractures. Int J Ayurvedic Med. 2013;1(6):129-35.
Nakae H, Yokoi A, Kodama H, Horikawa A. Comparison of the effects on rib fracture between the traditional Japanese medicine jidabokuippo and nonsteroidal anti-inflammatory drugs: a randomized controlled trial. Evid Based Complement Alternat Med. 2012;2012:837958.
https://doi.org/10.1155/2012/837958
PMid:22888367 PMCid:PMC3409613
Nakae H, Hebiguchi M, Okuyama M. Jidabokuippo use in patients with fractures of the extremities. Personalized Med Universe. 2015;4:66-9.
https://doi.org/10.1016/j.pmu.2014.10.002
Sharrard W. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J Bone Joint Surg Br. 1990;72(3):347-55.
https://doi.org/10.1302/0301-620X.72B3.2187877
PMid:2187877
Barker R, Kober A, Hoerauf K, Latzke D, Adel S, Kain ZN et al. Out-of-hospital auricular acupressure in elder patients with hip fracture: a randomized double-blinded trial. Acad Emerg Med. 2006;13(1):19-23.
https://doi.org/10.1111/j.1553-2712.2006.tb00979.x
PMid:16365322
Harris PE, Cooper K, Relton C, Thomas K. Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update. Int J Clin Pract. 2012;66(10):924-39.
https://doi.org/10.1111/j.1742-1241.2012.02945.x
PMid:22994327
Fjær EL, Landet ER, McNamara CL, Eikemo TA. The use of complementary and alternative medicine (CAM) in Europe. BMC Complement Med Ther. 2020;20(1):1-9.
https://doi.org/10.1186/s12906-020-02903-w
PMid:32252735 PMCid:PMC7137515
Mosavat SH, Heydari M, Hashempur MH, Dehghani SM. Use of complementary and alternative medicine among paediatric patients with hepatogastrointestinal diseases. East Mediterr Health J. 2018;24(10):1018.
https://doi.org/10.26719/2018.24.10.1018
PMid:30582145
Jones E, Nissen L, McCarthy A, Steadman K, Windsor C. Exploring the use of complementary and alternative medicine in cancer patients. Integr Cancer Ther. 2019;18:1534735419846986.
https://doi.org/10.1177/1534735419854134
Hashempur MH, Mosavat SH, Heydari M, Shams M. Medicinal plants' use among patients with dyslipidemia: an Iranian cross-sectional survey. J Complement Integr Med. 2019;16(3): 20180101.
https://doi.org/10.1515/jcim-2018-0101
PMid:30391934
Maleki E, Sadeghpour A, Taherifard E, Izadi B, Pasalar M, Akbari M. The effects of chicory supplementation on liver enzymes and lipid profiles in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of clinical evidence. Clin Nutr ESPEN. 2023;55:447-454.
https://doi.org/10.1016/j.clnesp.2023.04.025
PMid:37202083
Mbizo J, Okafor A, Sutton MA, Leyva B, Stone LM, Olaku O. Complementary and alternative medicine use among persons with multiple chronic conditions: results from the 2012 National Health Interview Survey. BMC Complement Altern Med. 2018;18(1):1-12.
https://doi.org/10.1186/s12906-018-2342-2
PMid:30340577 PMCid:PMC6194645
Heiran A, Bagheri Lankarani K, Bradley R, Simab A, Pasalar M. Efficacy of herbal treatments for functional dyspepsia: a systematic review and meta-analysis of randomized clinical trials. Phytother Res. 2022;36(2):686-704.
https://doi.org/10.1002/ptr.7333
PMid:34851546
Richardson J. Evidence-based complementary medicine: Rigour, relevance, and the swampy lowlands. Perspect Complement Altern Med Routledge. 2019:287-91.
https://doi.org/10.4324/9780203698372-37
Zhou Z, Chen B, Chen S, Lin M, Chen Y, Jin S et al. Applications of network pharmacology in traditional Chinese medicine research. Evid Based Complement Altern Med. 2020;2020:1646905.
https://doi.org/10.1155/2020/1646905
PMid:32148533 PMCid:PMC7042531
Hajimonfarednejad M, Ostovar M, Hasheminasab FS, Shariati MA, Thiruvengadam M, Raee MJ et al. Medicinal Plants for Viral Respiratory Diseases: A Systematic Review on Persian Medicine. Evid Based Complement Altern Med. 2023;2023:1928310.
https://doi.org/10.1155/2023/1928310
PMid:36818226 PMCid:PMC9937752
Wang L-H, Huang W, Wei D, Ding D-G, Liu Y-R, Wang J-J et al. Mechanisms of acupuncture therapy for simple obesity: an evidence-based review of clinical and animal studies on simple obesity. Evid Based Complement Altern Med. 2019;2019:5796381.
https://doi.org/10.1155/2019/5796381
PMid:30854010 PMCid:PMC6378065
Gamret AC, Price A, Fertig RM, Lev-Tov H, Nichols AJ. Complementary and alternative medicine therapies for psoriasis: a systematic review. JAMA Dermatol. 2018;154(11):1330-7.
https://doi.org/10.1001/jamadermatol.2018.2972
PMid:30193251
Zare H, Amiri Ardekani E, Tavakoli A, Bradley R, Tavakoli F, Pasalar M. Reporting of adverse effects of pomegranate in clinical studies: a systematic review. J Complement Integr Med. 2023;(0):0247.
https://doi.org/10.1515/jcim-2022-0247
PMid:37116077
Amini F, Namjooyan F, Zomorodian K, Zareshahrabadi Z, Shojaei K, Jaladat AM et al. The efficacy of complementary treatment with marshmallow (Althaea officinalis L.) on vulvovaginal candidiasis: A randomized double-blinded controlled clinical trial. Explore (NY). 2023;19(6):813-9.
https://doi.org/10.1016/j.explore.2023.04.005
PMid:37121836
Card EB, Obayemi JE, Shirima O, Lazaro M, Massawe H, Stanifer JW et al. Practices and perspectives of traditional bone setters in northern Tanzania. Ann Glob Health. 2020;86(1):7304448.
https://doi.org/10.5334/aogh.2878
PMid:32587811 PMCid:PMC7304448
OlaOlorun D, Oladiran I, Adeniran A. Complications of fracture treatment by traditional bonesetters in southwest Nigeria. Fam Pract. 2001;18(6):635-7.
https://doi.org/10.1093/fampra/18.6.635
PMid:11739353
Dada A, Giwa S, Yinusa W, Ugbeye M, Gbadegesin S. Complications of treatment of musculoskeletal injuries by bone setters. West Afr J Med. 2009;28(1):48426.
https://doi.org/10.4314/wajm.v28i1.48426
PMid:19662745
Onuminya JE. Performance of a trained traditional bonesetter in primary fracture care. S Afr Med J. 2006;96(4):320-2.
Onyemaechi NO, Itanyi IU, Ossai PO, Ezeanolue EE. Can traditional bonesetters become trained technicians Feasibility study among a cohort of Nigerian traditional bonesetters. Hum Resour Health. 2020;18(1):1-8.
https://doi.org/10.1186/s12960-020-00468-w
PMid:32197617 PMCid:PMC7085192
Heydarirad G, Sadeghi SMH, Khameneh SMH, Khodadoost M, Kamalinejad M, Jafari S et al. Effects of Natural Substances on Healing of Long Bone Fractures: A Narrative Review of Traditional Persian Medicine. Galen Med J. 2016;5(4):165-72.
Published
Issue
Section
License
Copyright (c) 2024 Galen Medical Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.
