Comparison of thyroid gland sonography index with serum antithyroid peroxidase, antithyroglobulin, and thyroid function tests in patients with Hashimoto thyroiditis

Comparison of Thyroid Gland Sonography Index in Patients with Hashimoto Thyroiditis.

Authors

  • Fatemeh Eftekharian 1-Endocrinology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran/ 2-Internal Medicine Department, Jahrom University of Medical Sciences, Jahrom, Iran
  • Gholamhossein Ranjbar Omrani Endocrinology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mohammad Hossein Dabbaghmanesh Endocrinology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Reza Sahraei Anesthesiology Department, Jahrom University of Medical Sciences, Jahrom, Iran
  • Mohammad Ali Behnam Medical Physics and Engineering Department, Shiraz University of Medical Sciences, Shiraz,
  • Marzieh Bakhshayeshkaram Endocrinology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mohammad Mahdi Dabbaghmanesh Endocrinology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Ultrasound examination of the thyroid has emerged as a useful diagnostic and prognostic tool, along with measuring serum titers of anti-thyroid peroxidase (TPO), anti-thyroglobulin (Tg), and thyroid hormones, in patients with Hashimoto's thyroiditis. So, we aimed at considering correlations of ultrasonographic, antibodies, and thyroid hormone levels. Methods: A total of 149 patients (118 females, 31 males; aged 18–60 years; mean age: 38.60 ± 8.03 years) who were diagnosed with Hashimoto's thyroiditis were enrolled in the study. The blood sample was taken to measure serum titers of free T3 (FT3) and T4 (FT4), TSH, anti-TPO, and anti-Tg antibody titers. The thyroid sonography of each patient was classified into one of the five grades by real-time ultrasound (US) based on echogenicity, thyroid size, and thyroid pattern. We evaluated whether there was a correlation between thyroid characteristics observed via ultrasound and serum levels of thyroid hormones, anti-TPO antibodies, and anti-Tg antibodies. Results: Nodular structures were detected in 54 (36.2%) patients (38 micro-nodular and 16 macro-nodular). Echogenicity was recorded as isoechoic in 15(10.07%) and hypoechoic in 119 (79.87%) subjects. Euthyroid ‎subjects had significantly thicker isthmus than overt and subclinical hypothyroid patients (p=0.018). Mean serum TSH, anti-Tg, and anti-TPO antibody titers showed a significant increase in patients with macro-nodules compared to those with micro-nodules and individuals without nodules (P<0.05).  The thickness of the isthmus had a significant negative correlation with FT4 (P=0.046; r=0.11) and FT3 (P=0.017; r=0.15), respectively. Thyroid autoantibodies had positive significant correlations with different parameters of thyroid volume (P<0.05). Conclusion: Thyroid US findings, in addition to serum anti-Tg and anti-TPO antibody titers, might be correlated with the severity and extent of Hashimoto's thyroiditis, but further evaluations are needed.

References


Published

2024-07-04

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Original Article