The Effect of Testosterone on Serum Lipid Profiles, Glucose, Insulin and Leptin: A Experimental Study Based Animal Model

Testosterone and Serum Lipid Profiles, Glucose, Insulin and Leptin

Authors

  • Adere Akhtar Yasuj University of Medical Sciences, Yasuj, Iran
  • Tooba Sohbatzadeh Student Research Committee, School of medicine, Alborz University of Medical Science, Alborz, Iran
  • Ramina Fazeli Student Research Committee, School of medicine, Alborz University of Medical Science, Alborz, Iran
  • Gholamhossein Ranjbar Omrani Endocrine and Metabolism Research Center, Department of Internal Medicine, Nemazee Hospital, Shiraz University of Medical Science, Shiraz, Iran
  • Melika Shojaei Endocrine and Metabolism Research Center, Department of Internal Medicine, Nemazee Hospital, Shiraz University of Medical Science, Shiraz, Iran

DOI:

https://doi.org/10.31661/gmj.v13i.3355

Keywords:

Leptin; Testosterone; Insulin; Lipid Profile; Glucose

Abstract

Background: Disruption in the endocrine system can cause many diseases. Based on this, the imbalance of sex hormones such as testosterone can change many serum factors. In this study, we examined the effect of testosterone on leptin levels, lipid profiles, and ultimately insulin resistance. Materials and Methods: Twenty one adult rats were divided into three groups of 7, including control group (C), olive oil group (O), and olive oil and testosterone group (OT). In the O and OT groups, they received olive oil and olive oil in combination with testosterone injection at the dose of 2 mg/kg/day, respectively. To evaluate the effects of hormonal imbalance on insulin resistance, various parameters such as leptin, triglyceride, cholesterol, glucose, and insulin were assessed. Results: The results showed that Triglyceride (TG) and insulin levels were higher in the OT group compared to the other two groups (P<0.05). In contrast, leptin and cholesterol levels were higher in group C compared to the other two groups (P<0.05) and glucose levels were higher in group O compared to the other two groups (P=0.01). Conclusion: In general, it can be said that testosterone can change serum lipid profiles, leptin, insulin, and glucose.

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Published

2024-08-11

How to Cite

Akhtar, A., Sohbatzadeh, T., Fazeli, R., Omrani, G. R., & Shojaei, M. (2024). The Effect of Testosterone on Serum Lipid Profiles, Glucose, Insulin and Leptin: A Experimental Study Based Animal Model: Testosterone and Serum Lipid Profiles, Glucose, Insulin and Leptin. Galen Medical Journal, 13, e3355. https://doi.org/10.31661/gmj.v13i.3355

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