Exploring the Relationship Between Gingivitis and Hypothyroidism in Children
Relationship Between Gingivitis and Hypothyroidism in Children
DOI:
https://doi.org/10.31661/gmj.v13i.3409Keywords:
Gingivitis; Hypothyroidism; Thyroid Hormones; Oral Health; Inflammation; Interdisciplinary CareAbstract
Periodontitis common oral health problem for children, which involves the inflammation of gum tissue. Hypothyroidism, which is a systemic disorder characterized by the decrease in thyroid hormone levels, has its patients suffering from many dysfunctions in the body. In spite of the fact that they apparently belong to distinct spheres, recent research looks suspiciously for a probable correlation between the two diseases, i.e. gingivitis and hypothyroidism. This paper is a comprehensive narrative review that focuses on explaining the unique relationship between these two conditions in children as it relates to the mechanisms, clinical manifestations, diagnostic difficulties, and therapeutic approaches. Through the process of literature review syntheses, previously unknown interrelations between hypothyroidism and gingival health are discovered. Therefore, the multidisciplinary approach may be one of the factors that improve the overall condition of the patients with these comorbidities as well as the effectiveness of the treatment due to the partnership through the cooperation between dental and endocrine specialists.
References
Slots J. Periodontitis: facts, fallacies and the future. Periodontology 2000. 2017;75(1):7-23.
https://doi.org/10.1111/prd.12221
PMid:28758294
Chatzisymeonidou S, Papadopoulos P, Andreadis D, Poulopoulos A. Desquamative gingivitis: Clinical and epidemiological findings in patients from Northern Greece. Balkan Journal of Dental Medicine. 2023;27(3):148-53.
https://doi.org/10.5937/bjdm2303148C
Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. The Lancet. 2017;390(10101):1550-62.
https://doi.org/10.1016/S0140-6736(17)30703-1
PMid:28336049
Graves DT, Corrêa JD, Silva TA. The Oral Microbiota Is Modified by Systemic Diseases. J Dent Res. 2019;98(2):148-56.
https://doi.org/10.1177/0022034518805739
PMid:30359170 PMCid:PMC6761737
López-Santacruz HD, Herrera-Badillo DA, Márquez-Preciado R, Torre-Delgadillo G, Rosales-Berber MÁ. Improvement in Oral Health and Compliance in a Child with Congenital Hypothyroidism. International Journal of Dental Sciences. 2019;21(3):45-51.
https://doi.org/10.15517/ijds.2019.37850
Manohar J, Dinesh SS. Periodontal status among patients with hypothyroidism visiting a private dental hospital in chennai. IJPR. 2021;13(1):p1236.
https://doi.org/10.31838/ijpr/2021.13.01.201
Ushanthika T, Ganapathy D, Sivakumar M. Prevalence of hypothyroidism in women with dental problems. IJPR. 2020 Jul 2:p2148.
Morawska K, Maciejczyk M, Zięba S, Popławski Ł, Kita-Popławska A, Krętowski J, et al. Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto's Thyroiditis Patients. Mediators Inflamm. 2021;1:3192409.
https://doi.org/10.1155/2021/3192409
PMid:34335085 PMCid:PMC8289575
Üner D, Izol B. The effect of periodontal status on the TSH and FT4 levels. Journal of Oral Health and Oral Epidemiology. 2024; 13(2): 49-54.
Venkatesh Babu N, Patel P. Oral health status of children suffering from thyroid disorders. J Indian Soc Pedod Prev Dent. 2016;34(2):139.
https://doi.org/10.4103/0970-4388.180443
PMid:27080964
Aldulaijan HA, Cohen RE, Stellrecht EM, Levine MJ, Yerke LM. Relationship between hypothyroidism and periodontitis: A scoping review. Clinical and Experimental Dental Research. 2020;6(1):147-57.
https://doi.org/10.1002/cre2.247
PMid:32067402 PMCid:PMC7025985
Shostenko A. Immunological characteristics of patients with generalized catarrhal gingivitis. The Scientific Heritage. 2020;47-2 (47):72-4.
Patel P. Comparative Assessment of Oral Health Status in Children Suffering from Thyroid Disorder (Master's thesis, Rajiv Gandhi University of Health Sciences (India)), 2016.
Polishchuk TV, Sheshukova OV, Trufanova VР, Illiashenko YI, Bauman SS, Mosiienko AS. Pathology of the thyroid GL and in children as a factor of dental morbidity. Problems of Endocrine Pathology. 2021;75(1):117-22.
https://doi.org/10.21856/j-PEP.2021.1.15
Wilson SA, Stem LA, Bruehlman RD. Hypothyroidism: Diagnosis and treatment. American family physician. 2021;103(10):605-13.
Кіцак ТС. The influence of thyroid pathology on the course of periodontal disease in children and ways to correct it. Медицина сьогодні і завтра. 2021;90(3):64-74.
https://doi.org/10.35339/msz.2021.90.3.kit
Bhankhar RR, Hungund S, Kambalyal P, Singh V, Jain K. Effect of Nonsurgical Periodontal Therapy on Thyroid Stimulating Hormone in Hypothyroid Patients with Periodontal Diseases. Indian J Dent Res. 2017;28(1):16.
https://doi.org/10.4103/ijdr.IJDR_174_16
PMid:28393812
Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, Van Vliet G, et al. European Society for Paediatric Endocrinology Consensus Guidelines on Screening, Diagnosis, and Management of Congenital Hypothyroidism. J Clin Endocrinol Metab. 2014;99(2):363-84.
https://doi.org/10.1210/jc.2013-1891
PMid:24446653 PMCid:PMC4207909
Duda-Sobczak A, Zozulinska-Ziolkiewicz D, Wyganowska M. Better Gingival Status in Patients with Comorbidity of Type 1 Diabetes and Thyroiditis in Comparison with Patients with Type 1 Diabetes and No Thyroid Disease-A Preliminary Study. Int J Environ Res Public Health. 2023;20(4):3008.
https://doi.org/10.3390/ijerph20043008
PMid:36833702 PMCid:PMC9963864
Liu X, Xu J, Li S, Wang X, Liu J, Li X. The prevalence of gingivitis and related risk factors in schoolchildren aged 6-12 years old. BMC Oral Health. 2022;22(1):623.
https://doi.org/10.1186/s12903-022-02670-9
PMid:36544102 PMCid:PMC9768968
Gare J, Kanoute A, Orsini G, Gonçalves LS, Ali Alshehri F, Bourgeois D, et al. Prevalence, severity of extension, and risk factors of gingivitis in a 3-month pregnant population: a multicenter cross-sectional study. Journal of Clinical Medicine. 2023;12(9):3349.
https://doi.org/10.3390/jcm12093349
PMid:37176789 PMCid:PMC10179599
Khade J, Khade AM, Pantawane S, Phadnaik M, Siddique A, Bandre GR. Severe Chronic Gingivitis in Association With Hypothyroidism and Grade 2 Adenoid Hypertrophy: A Case Report. Cureus. 2023 Nov;15(11):PMC10751603.
https://doi.org/10.7759/cureus.49506
Kothiwale S, Panjwani V. Impact of thyroid hormone dysfunction on periodontal disease. Journal of the Scientific Society. 2016;43(1):34.
https://doi.org/10.4103/0974-5009.175456
Cuan-Baltazar Y, Soto-Vega E. Microorganisms associated to thyroid autoimmunity. Autoimmun Rev. 2020;19(9):102614.
https://doi.org/10.1016/j.autrev.2020.102614
PMid:32663624
Ay ZY, Tekneci A, Tan A, Işık AR, Pirgon Ö. Periodontal Health Status of Adolescents with Hashimoto Thyroiditis. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2022;13(1):30-9.
https://doi.org/10.22312/sdusbed.1028196
Carlos Fabue L, Jiménez Soriano Y, Sarrión Pérez MG. Dental management of patients with endocrine disorders. J Clin Exp Dent. 2010;2(4):196-203.
https://doi.org/10.4317/jced.2.e196
Chowdhary Z, Mohan R, Mehrotra S. An unusual association of gingival enlargement with generalized aggressive periodontitis combined with hypothyroidism and plasma cell gingivitis. Journal of Interdisciplinary Dentistry. 2017;7(3):122-4.
https://doi.org/10.4103/jid.jid_8_17
Saminsky M. Periodontal Disease and Dental Caries among children and Adolescents Suffering from Endocrine Disorders-A Literature Review. Pediatric Endocrinology Reviews (PER). 2017 Dec 1;15(2):371-8.
Belstrøm D, Damgaard C, Könönen E, Gürsoy M, Holmstrup P, Gürsoy UK. Salivary cytokine levels in early gingival inflammation. J Oral Microbiol. 2017;9(1):1364101.
https://doi.org/10.1080/20002297.2017.1364101
PMid:28839521 PMCid:PMC5560406
Roberts HM, Yonel Z, Kantarci A, Grant MM, Chapple IL. Impact of gingivitis on circulating neutrophil reactivity and gingival crevicular fluid inflammatory proteins. Int J Environ Res Public Health. 2022;19(10):6339.
https://doi.org/10.3390/ijerph19106339
PMid:35627876 PMCid:PMC9141451
De Luca R, Davis PJ, Lin HY, Gionfra F, Percario ZA, Affabris E, et al. Thyroid hormones interaction with immune response, inflammation and non-thyroidal illness syndrome. Front Cell Dev Biol. 2021;8:614030.
https://doi.org/10.3389/fcell.2020.614030
PMid:33553149 PMCid:PMC7859329
Shcherba V, Krynytska I, Marushchak M, Korda M. The qualitative and quantitative structure of oral microbiocenosis in rats with periodontitis in a setting of hyper- and hypothyroidism. Rom J Diabetes Nutr Metab Dis. 2019;26(3):293-304.
https://doi.org/10.2478/rjdnmd-2019-0030
Güngör Borsöken A, Gursel Surmelıoglu D. The Effect of Saliva and Dental Caries of the Patients with Hashimoto Thyroiditis on Cytokine Levels. Niger J Clin Pract. 2024;27(1):8.
https://doi.org/10.4103/njcp.njcp_820_22
PMid:38317029
Köhrle J, Frädrich C. Thyroid hormone system disrupting chemicals. Best Pract Res Clin Endocrinol Metab. 2021;35(5):101562.
https://doi.org/10.1016/j.beem.2021.101562
PMid:34274233
van der Spek AH, Fliers E, Boelen A. Thyroid hormone and deiodination in innate immune cells. Endocrinology. 2021;162(1):bqaa200.
https://doi.org/10.1210/endocr/bqaa200
PMid:33275661
Zhan L, Feng H fang, Liu H qing, Guo L tao, Chen C, Yao X li, et al. Immune checkpoint inhibitors-related thyroid dysfunction: epidemiology, clinical presentation, possible pathogenesis, and management. Front Endocrinol. 2021;12:649863.
https://doi.org/10.3389/fendo.2021.649863
PMid:34177799 PMCid:PMC8224170
Morais A, Resende M, Pereira J. Tireoidite de Hashimoto e Doença Periodontal: Uma Revisão Narrativa. Acta Médica Portuguesa. 2016;29(10):651-7.
https://doi.org/10.20344/amp.6704
PMid:28103461
Yavropoulou MP, Sfikakis PP, Chrousos GP. Immune system effects on the endocrine system. Endotext : [Internet]; 2023.
Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3(1):17038.
https://doi.org/10.1038/nrdp.2017.38
PMid:28805207
Jaeger M, Sloot YJE, Horst RT, Chu X, Koenen HJPM, Koeken VACM, et al. Thyrotrophin and thyroxine support immune homeostasis in humans. Immunology. 2021;163(2):155-68.
https://doi.org/10.1111/imm.13306
PMid:33454989 PMCid:PMC8114202
Polishchuk TV, Sheshukova OV, Trufanova VР, Illiashenko YI, Bauman SS, Mosiienko AS. Pathology of the thyroid GL and in children as a factor of dental morbidit y (mini review). Problems of Endocrine Pathology. 2021 Mar 3;75(1):117-22.
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Galen Medical Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.