Exploring the Relationship Between Gingivitis and Hypothyroidism in Children

Relationship Between Gingivitis and Hypothyroidism in Children

Authors

  • Andisheh Amini Department of Pediatrics, School of Dentistry, Isfahan University of Medical Science, Isfahan, Iran
  • Pouria Farahani Shahid Beheshti University of Medical Science, Faculty of Dentistry, Tehran, Iran
  • Mahsa Etemadi Department of Periodontology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  • Pardis Khoshnood Department of Restorative Dentistry, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Asieh Mozaffari Department of Periodontics, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
  • Bahareh Sanaee Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

DOI:

https://doi.org/10.31661/gmj.v13i.3409

Keywords:

Gingivitis; Hypothyroidism; Thyroid Hormones; Oral Health; Inflammation; Interdisciplinary Care

Abstract

Periodontitis common oral health problem for children, which involves the inflammation of gum tissue. Hypothyroidism, which is a systemic disorder characterized by the decrease in thyroid hormone levels, has its patients suffering from many dysfunctions in the body. In spite of the fact that they apparently belong to distinct spheres, recent research looks suspiciously for a probable correlation between the two diseases, i.e. gingivitis and hypothyroidism. This paper is a comprehensive narrative review that focuses on explaining the unique relationship between these two conditions in children as it relates to the mechanisms, clinical manifestations, diagnostic difficulties, and therapeutic approaches. Through the process of literature review syntheses, previously unknown interrelations between hypothyroidism and gingival health are discovered. Therefore, the multidisciplinary approach may be one of the factors that improve the overall condition of the patients with these comorbidities as well as the effectiveness of the treatment due to the partnership through the cooperation between dental and endocrine specialists.

References

Slots J. Periodontitis: facts, fallacies and the future. Periodontology 2000. 2017;75(1):7-23.

https://doi.org/10.1111/prd.12221

PMid:28758294

Chatzisymeonidou S, Papadopoulos P, Andreadis D, Poulopoulos A. Desquamative gingivitis: Clinical and epidemiological findings in patients from Northern Greece. Balkan Journal of Dental Medicine. 2023;27(3):148-53.

https://doi.org/10.5937/bjdm2303148C

Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. The Lancet. 2017;390(10101):1550-62.

https://doi.org/10.1016/S0140-6736(17)30703-1

PMid:28336049

Graves DT, Corrêa JD, Silva TA. The Oral Microbiota Is Modified by Systemic Diseases. J Dent Res. 2019;98(2):148-56.

https://doi.org/10.1177/0022034518805739

PMid:30359170 PMCid:PMC6761737

López-Santacruz HD, Herrera-Badillo DA, Márquez-Preciado R, Torre-Delgadillo G, Rosales-Berber MÁ. Improvement in Oral Health and Compliance in a Child with Congenital Hypothyroidism. International Journal of Dental Sciences. 2019;21(3):45-51.

https://doi.org/10.15517/ijds.2019.37850

Manohar J, Dinesh SS. Periodontal status among patients with hypothyroidism visiting a private dental hospital in chennai. IJPR. 2021;13(1):p1236.

https://doi.org/10.31838/ijpr/2021.13.01.201

Ushanthika T, Ganapathy D, Sivakumar M. Prevalence of hypothyroidism in women with dental problems. IJPR. 2020 Jul 2:p2148.

Morawska K, Maciejczyk M, Zięba S, Popławski Ł, Kita-Popławska A, Krętowski J, et al. Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto's Thyroiditis Patients. Mediators Inflamm. 2021;1:3192409.

https://doi.org/10.1155/2021/3192409

PMid:34335085 PMCid:PMC8289575

Üner D, Izol B. The effect of periodontal status on the TSH and FT4 levels. Journal of Oral Health and Oral Epidemiology. 2024; 13(2): 49-54.

Venkatesh Babu N, Patel P. Oral health status of children suffering from thyroid disorders. J Indian Soc Pedod Prev Dent. 2016;34(2):139.

https://doi.org/10.4103/0970-4388.180443

PMid:27080964

Aldulaijan HA, Cohen RE, Stellrecht EM, Levine MJ, Yerke LM. Relationship between hypothyroidism and periodontitis: A scoping review. Clinical and Experimental Dental Research. 2020;6(1):147-57.

https://doi.org/10.1002/cre2.247

PMid:32067402 PMCid:PMC7025985

Shostenko A. Immunological characteristics of patients with generalized catarrhal gingivitis. The Scientific Heritage. 2020;47-2 (47):72-4.

Patel P. Comparative Assessment of Oral Health Status in Children Suffering from Thyroid Disorder (Master's thesis, Rajiv Gandhi University of Health Sciences (India)), 2016.

Polishchuk TV, Sheshukova OV, Trufanova VР, Illiashenko YI, Bauman SS, Mosiienko AS. Pathology of the thyroid GL and in children as a factor of dental morbidity. Problems of Endocrine Pathology. 2021;75(1):117-22.

https://doi.org/10.21856/j-PEP.2021.1.15

Wilson SA, Stem LA, Bruehlman RD. Hypothyroidism: Diagnosis and treatment. American family physician. 2021;103(10):605-13.

Кіцак ТС. The influence of thyroid pathology on the course of periodontal disease in children and ways to correct it. Медицина сьогодні і завтра. 2021;90(3):64-74.

https://doi.org/10.35339/msz.2021.90.3.kit

Bhankhar RR, Hungund S, Kambalyal P, Singh V, Jain K. Effect of Nonsurgical Periodontal Therapy on Thyroid Stimulating Hormone in Hypothyroid Patients with Periodontal Diseases. Indian J Dent Res. 2017;28(1):16.

https://doi.org/10.4103/ijdr.IJDR_174_16

PMid:28393812

Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, Van Vliet G, et al. European Society for Paediatric Endocrinology Consensus Guidelines on Screening, Diagnosis, and Management of Congenital Hypothyroidism. J Clin Endocrinol Metab. 2014;99(2):363-84.

https://doi.org/10.1210/jc.2013-1891

PMid:24446653 PMCid:PMC4207909

Duda-Sobczak A, Zozulinska-Ziolkiewicz D, Wyganowska M. Better Gingival Status in Patients with Comorbidity of Type 1 Diabetes and Thyroiditis in Comparison with Patients with Type 1 Diabetes and No Thyroid Disease-A Preliminary Study. Int J Environ Res Public Health. 2023;20(4):3008.

https://doi.org/10.3390/ijerph20043008

PMid:36833702 PMCid:PMC9963864

Liu X, Xu J, Li S, Wang X, Liu J, Li X. The prevalence of gingivitis and related risk factors in schoolchildren aged 6-12 years old. BMC Oral Health. 2022;22(1):623.

https://doi.org/10.1186/s12903-022-02670-9

PMid:36544102 PMCid:PMC9768968

Gare J, Kanoute A, Orsini G, Gonçalves LS, Ali Alshehri F, Bourgeois D, et al. Prevalence, severity of extension, and risk factors of gingivitis in a 3-month pregnant population: a multicenter cross-sectional study. Journal of Clinical Medicine. 2023;12(9):3349.

https://doi.org/10.3390/jcm12093349

PMid:37176789 PMCid:PMC10179599

Khade J, Khade AM, Pantawane S, Phadnaik M, Siddique A, Bandre GR. Severe Chronic Gingivitis in Association With Hypothyroidism and Grade 2 Adenoid Hypertrophy: A Case Report. Cureus. 2023 Nov;15(11):PMC10751603.

https://doi.org/10.7759/cureus.49506

Kothiwale S, Panjwani V. Impact of thyroid hormone dysfunction on periodontal disease. Journal of the Scientific Society. 2016;43(1):34.

https://doi.org/10.4103/0974-5009.175456

Cuan-Baltazar Y, Soto-Vega E. Microorganisms associated to thyroid autoimmunity. Autoimmun Rev. 2020;19(9):102614.

https://doi.org/10.1016/j.autrev.2020.102614

PMid:32663624

Ay ZY, Tekneci A, Tan A, Işık AR, Pirgon Ö. Periodontal Health Status of Adolescents with Hashimoto Thyroiditis. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2022;13(1):30-9.

https://doi.org/10.22312/sdusbed.1028196

Carlos Fabue L, Jiménez Soriano Y, Sarrión Pérez MG. Dental management of patients with endocrine disorders. J Clin Exp Dent. 2010;2(4):196-203.

https://doi.org/10.4317/jced.2.e196

Chowdhary Z, Mohan R, Mehrotra S. An unusual association of gingival enlargement with generalized aggressive periodontitis combined with hypothyroidism and plasma cell gingivitis. Journal of Interdisciplinary Dentistry. 2017;7(3):122-4.

https://doi.org/10.4103/jid.jid_8_17

Saminsky M. Periodontal Disease and Dental Caries among children and Adolescents Suffering from Endocrine Disorders-A Literature Review. Pediatric Endocrinology Reviews (PER). 2017 Dec 1;15(2):371-8.

Belstrøm D, Damgaard C, Könönen E, Gürsoy M, Holmstrup P, Gürsoy UK. Salivary cytokine levels in early gingival inflammation. J Oral Microbiol. 2017;9(1):1364101.

https://doi.org/10.1080/20002297.2017.1364101

PMid:28839521 PMCid:PMC5560406

Roberts HM, Yonel Z, Kantarci A, Grant MM, Chapple IL. Impact of gingivitis on circulating neutrophil reactivity and gingival crevicular fluid inflammatory proteins. Int J Environ Res Public Health. 2022;19(10):6339.

https://doi.org/10.3390/ijerph19106339

PMid:35627876 PMCid:PMC9141451

De Luca R, Davis PJ, Lin HY, Gionfra F, Percario ZA, Affabris E, et al. Thyroid hormones interaction with immune response, inflammation and non-thyroidal illness syndrome. Front Cell Dev Biol. 2021;8:614030.

https://doi.org/10.3389/fcell.2020.614030

PMid:33553149 PMCid:PMC7859329

Shcherba V, Krynytska I, Marushchak M, Korda M. The qualitative and quantitative structure of oral microbiocenosis in rats with periodontitis in a setting of hyper- and hypothyroidism. Rom J Diabetes Nutr Metab Dis. 2019;26(3):293-304.

https://doi.org/10.2478/rjdnmd-2019-0030

Güngör Borsöken A, Gursel Surmelıoglu D. The Effect of Saliva and Dental Caries of the Patients with Hashimoto Thyroiditis on Cytokine Levels. Niger J Clin Pract. 2024;27(1):8.

https://doi.org/10.4103/njcp.njcp_820_22

PMid:38317029

Köhrle J, Frädrich C. Thyroid hormone system disrupting chemicals. Best Pract Res Clin Endocrinol Metab. 2021;35(5):101562.

https://doi.org/10.1016/j.beem.2021.101562

PMid:34274233

van der Spek AH, Fliers E, Boelen A. Thyroid hormone and deiodination in innate immune cells. Endocrinology. 2021;162(1):bqaa200.

https://doi.org/10.1210/endocr/bqaa200

PMid:33275661

Zhan L, Feng H fang, Liu H qing, Guo L tao, Chen C, Yao X li, et al. Immune checkpoint inhibitors-related thyroid dysfunction: epidemiology, clinical presentation, possible pathogenesis, and management. Front Endocrinol. 2021;12:649863.

https://doi.org/10.3389/fendo.2021.649863

PMid:34177799 PMCid:PMC8224170

Morais A, Resende M, Pereira J. Tireoidite de Hashimoto e Doença Periodontal: Uma Revisão Narrativa. Acta Médica Portuguesa. 2016;29(10):651-7.

https://doi.org/10.20344/amp.6704

PMid:28103461

Yavropoulou MP, Sfikakis PP, Chrousos GP. Immune system effects on the endocrine system. Endotext : [Internet]; 2023.

Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3(1):17038.

https://doi.org/10.1038/nrdp.2017.38

PMid:28805207

Jaeger M, Sloot YJE, Horst RT, Chu X, Koenen HJPM, Koeken VACM, et al. Thyrotrophin and thyroxine support immune homeostasis in humans. Immunology. 2021;163(2):155-68.

https://doi.org/10.1111/imm.13306

PMid:33454989 PMCid:PMC8114202

Polishchuk TV, Sheshukova OV, Trufanova VР, Illiashenko YI, Bauman SS, Mosiienko AS. Pathology of the thyroid GL and in children as a factor of dental morbidit y (mini review). Problems of Endocrine Pathology. 2021 Mar 3;75(1):117-22.

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Published

2024-06-20

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Vol. 13 (2024): 2024: In Progress

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Review Article

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