Evaluation of Changes in Hemorheological Variables in Multiple Sclerosis Patients

Evaluation of Changes in Hemorheological Variables in Multiple Sclerosis Patients

Authors

  • Mahdi Yaseliani Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Abdolreaza Naser Moghadasi Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  • Mohammad Ali Sahraian Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Neurology Department, Sina Hospital, Tehran, Iran
  • Mehrdad Karimi Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mahdi Alizadeh Vaghasloo Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Hossein Rezaeizadeh Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.31661/gmj.v13i.3513

Keywords:

Multiple Sclerosis; Hemorheology; Cerebral Blood Flow; Red Blood Cell

Abstract

Background: Multiple sclerosis (MS) is a neurodegenerative condition primarily attributed to immune system dysregulation. However, emerging evidence suggests that additional factors, such as neurodegeneration independent of immune processes, may also contribute to MS pathology. Given the significant cerebral hypoperfusion observed in MS patients from the early to advanced stages of the disease, investigating hemorheology or blood rheology, which involves studying blood flow properties and plasma protein compounds, can contribute to understanding the underlying pathology of MS. This study aims to evaluate changes in hemorheological variables in MS patients, which may offer a better understanding of the disease’s progression and its impact on blood flow dynamics. Materials and Methods: In this study, we assessed the modifications in key factors impacting hemorheology in articles related to MS. Some keywords including MS, Blood Viscosity, Hemorheology, and brain perfusion were searched in PubMed, Google Scholar, and Scopus. The searches were limited to studies published in English languages from 2000 to 2023. Results: Among the 110 articles found in the search, finally, 35 articles were included in the review. In some studies, patients with MS were examined for rheological blood properties and demonstrated an appreciable increase in blood viscosity. Furthermore, declines in cerebral blood volume and cerebral blood flow in MS are linked to the deterioration of physical disability. In our investigation, we focused on the key factors influencing hemorheology and examined their variations in the articles about patients with MS. Conclusion: The reduction of tissue blood perfusion caused by changes in blood hemorheology can be considered as one of the causes of the development or exacerbation of MS, but to estimate hemorheological changes in MS, we need to conduct more detailed studies on humans, which we hope will provide new solutions for the therapists of this disease.

References

Hunter SF. Overview and diagnosis of multiple sclerosis. Am J Manag Care. 2016; 22(6): s141-s150.

Alivirdiloo V, et al. Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain. Med Chem Res. 2024 Jun 7:1-9.

https://doi.org/10.1007/s00044-024-03237-9

Sheikhnia F, et al. Exploring the Therapeutic Potential of Quercetin in Cancer Treatment: Targeting Long Non-Coding RNAs. PATHOL RES PRACT. 2024 May 29:155374.

https://doi.org/10.1016/j.prp.2024.155374

PMid:38889494

D'Haeseleer M, et al. Cerebral hypoperfusion: a new pathophysiologic concept in multiple sclerosis. J Cereb Blood Flow Metab. 2015; 35(9): 406-10.

https://doi.org/10.1038/jcbfm.2015.131

PMid:26104292 PMCid:PMC4640326

Baskurt OK. Mechanisms of blood rheology alterations. Biomed Res J. 2007; 69:170.

Khezerlouy-Aghdam N, et al. Challenging in pulmonary thromboembolism diagnosis in patients with disproportionate pulmonary hypertension and severe mitral stenosis: Report of two cases. Clin Case Rep. 2024 Mar 7;12(3):e8597.

https://doi.org/10.1002/ccr3.8597

PMid:38464564 PMCid:PMC10920307

Lagana MM, et al. Relationship between MRI perfusion and clinical severity in multiple sclerosis. Neural Regen Res. 2020; 15(4): 646-652.

https://doi.org/10.4103/1673-5374.266906

PMid:31638086 PMCid:PMC6975150

Mey GM,Mahajan KR, et al. Neurodegeneration in multiple sclerosis. WIREs Mech Dis. 2023;15(1): e1583.

https://doi.org/10.1002/wsbm.1583

PMid:35948371 PMCid:PMC9839517

Rodríguez Murúa S, et al. The Immune Response in Multiple Sclerosis. Annu Rev Pathol. 2022; 17:121-139.

https://doi.org/10.1146/annurev-pathol-052920-040318

PMid:34606377

Safaie N, et al. SGLT2 inhibitors and AMPK: The road to cellular housekeeping? Cell Biochem Funct. 2024 Jan;42(1):e3922.

https://doi.org/10.1002/cbf.3922

PMid:38269506

Nader E, et al. Blood Rheology: Key Parameters, Impact on Blood Flow, Role in Sickle Cell Disease and Effects of Exercise. Front Physiol. 2019; 10:1329.

https://doi.org/10.3389/fphys.2019.01329

PMid:31749708 PMCid:PMC6842957

Rostami AA, et al. The Crosstalk between Coronary Artery Bypass Grafting and miRNAs. Biol Bull Russ Acad Sci. 2023; 50:1167-1171.

https://doi.org/10.1134/S1062359023602082

Marvast AF, et al. The Effect of N-acetylcysteine on Alprazolam Withdrawal Symptoms in Wistar Male Albino Rats. Cogn J. 2024;4(4):316-328.

https://doi.org/10.47760/cognizance.2024.v04i04.023

Jakimovski D, et al. Cortical and Deep Gray Matter Perfusion Associations With Physical and Cognitive Performance in Multiple Sclerosis Patients. Front Neurol. 2020; 11:700.

https://doi.org/10.3389/fneur.2020.00700

PMid:32765407 PMCid:PMC7380109

Sowa P, et al. Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis. Neuroradiology. 2017; 59(7): 655-664.

https://doi.org/10.1007/s00234-017-1849-4

PMid:28585082

Hojjat SP, et al. Cortical perfusion alteration in normal-appearing gray matter is most sensitive to disease progression in relapsingremitting multiple sclerosis. AJNR Am J Neuroradiol. 2016; 37(8):1454- 1461.

https://doi.org/10.3174/ajnr.A4737

PMid:27012299 PMCid:PMC4983506

Vitorino R, et al. Regional frontal perfusion deficits in relapsing-remitting multiple sclerosis with cognitive decline. AJNR Am J Neuroradiol. 2016; 37(10):1800-1807.

https://doi.org/10.3174/ajnr.A4824

PMid:27197989 PMCid:PMC5116278

Jakimovski D, et al. Vascular aspects of multiple sclerosis: emphasis on perfusion and cardiovascular comorbidities. Expert Rev Neurother. 2019; 19(5): 445-458.

https://doi.org/10.1080/14737175.2019.1610394

PMid:31003583

Masoumi S, et al. Dual Left Anterior Descending Artery: Clinical Overview and Interventional Management. J Tehran Heart Cent. 2023 Apr;18(2):146-150.

https://doi.org/10.18502/jthc.v18i2.13326

PMid:37637287 PMCid:PMC10459347

Toufan M, et al. Biatrial Myxoma with a Shared Stalk: A Case Report. J Tehran Heart Cent. 2021 Oct;16(4):174-177.

https://doi.org/10.18502/jthc.v16i4.8604

PMid:35935553 PMCid:PMC9308883

Toopchizadeh V, et al. Prevalence of Vitamin D Deficiency and Associated Risk Factors in Cerebral Palsy A study in North West of Iran. Iran J Child Neurol. 2018 Spring;12(2):25-32.

Gorgzadeh A, et al. Investigating the Properties and Cytotoxicity of Cisplatin-Loaded NanoPolybutylcyanoacrylate on Breast Cancer Cells. Asian Pac J Cancer Biol. 2023 Nov 6;8(4):345-50.

https://doi.org/10.31557/apjcb.2023.8.4.345-350

Mostafavi M, Mehrnaz F, et al. State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment. Strahlentherapie und Onkologie. (2024); :1-12.

https://doi.org/10.1007/s00066-024-02301-y

PMid:39367110

Mohammadi M, et al. Correlation of PTEN signaling pathway and miRNA in breast cancer. Mol Biol Rep. 2024 Dec;51(1):221.

https://doi.org/10.1007/s11033-023-09191-w

PMid:38281224

Rahmani Z, et al. Evaluation of the Relation between Tuning Fork Tests, Glue ear Presence, and Conductive Hearing Loss in Patients with Otitis Media with Effusion. Arch Otolaryngol faci plas Surg. 2022 Jan 1;8(1):1-8.

Mansour A, et al. MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Can Imag. 2014;14:22.

https://doi.org/10.1186/1470-7330-14-22

PMid:25608570 PMCid:PMC4331827

Ali-Khiavi P, et al. The Therapeutic Potential of Exosome Therapy in Sepsis Management: Addressing Complications and Improving Outcomes". Cell Biochem Biophys. (2024); : 1-20.

https://doi.org/10.1007/s12013-024-01564-7

PMid:39363035

Taheri F, et al. Aging Process and Related Diseases. Kindle. 2023 May 4;3(1):1-17.

Chien S. White blood cell rheology, in Clinical Blood Rheology. CRC Press. 2019; :87-109.

https://doi.org/10.1201/9780429261176-5

Rahimian Z, et al. Antiseizure Effects of Peganum harmala L and Lavandula angustifolia. Biomed Res Int. 2023 ;2023(1):4121998.

https://doi.org/10.1155/2023/4121998

PMid:38089644 PMCid:PMC10715855

Mohammadi AT, et al. Neuroscience in the 21st Century. New Tools and Techniques Driving Exciting Discoveries: Nobel Sci; 2024.

Sadat Rafiei SK, et al. Saffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials. Nutr Metab Insights. 2023 Jul; 16:11786388231160317.

https://doi.org/10.1177/11786388231160317

PMid:37484523 PMCid:PMC10357048

Basmenj ER, et al. Engineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis. Sci Rep. 2023 Nov 8;13(1):19421.

https://doi.org/10.1038/s41598-023-46408-1

PMid:37940672 PMCid:PMC10632461

Sohrabi N, et al. Using different geometries on the amount of heat transfer in a shell and tube heat exchanger using the finite volume method. Case Stud Therm Eng. 2024 Mar 1; 55:104037.

https://doi.org/10.1016/j.csite.2024.104037

Hon GM, et al. The haematological profile of patients with multiple sclerosis. Open J Mod Neurosurg. 2012; 2(3): 36-44.

https://doi.org/10.4236/ojmn.2012.23008

Zarean Shahraki S, et al. Time related survival prediction in molecular subtypes of breast cancer using time-to-event deep-learning-based models. Front oncol. 2023 Jun 5;13:1147604.

https://doi.org/10.3389/fonc.2023.1147604

PMid:37342184 PMCid:PMC10277681

Bayani A, et al. Performance of machine learning techniques on prediction of esophageal varices grades among patients with cirrhosis. Clin Chem Lab Med (CCLM). 2022 Nov 1;60(12):1955-62.

https://doi.org/10.1515/cclm-2022-0623

PMid:36044750

Hosseini M, et al. RoboCup 2016 best humanoid award winner team baset adult-size. RoboCup 2016: Robot World Cup XX 20: Springer Int Pub; 2017.

https://doi.org/10.1007/978-3-319-68792-6_39

McFarlin BL, et al. Enhanced identification of women at risk for preterm birth via quantitative ultrasound: a prospective cohort study. Am J Obstet Gynecol. 2023 Dec 7:101250.

https://doi.org/10.1016/j.ajogmf.2023.101250

PMid:38070676

Entezami M, et al. Green Drug Supply Chain Investigation by Time-Market Balance and Risk. World J Eng. 2023 Aug 29;11(3):611-31.

https://doi.org/10.4236/wjet.2023.113042

Chien S. Red cell deformability and its relevance to blood flow. Annual review of physiology. 1987 Mar;49(1):177-92.

https://doi.org/10.1146/annurev.physiol.49.1.177

PMid:3551796

Imani A, et al. Evaluation of the Association between Serum Levels of Vitamin D and Benign Paroxysmal Positional Vertigo (BPPV): A Case-Control Study. Arch Otolaryngol faci plas Surg. 2022 Jan 1;8(1):1-6.

Shakerimoghaddam A, et al. Prevalence of Pseudomonas aeruginosa and its antibiotic resistance in patients who have received Hematopoietic Stem-Cell Transplantation; A globally Systematic Review. Microb Pathog. 2023 Sep 27:106368.

https://doi.org/10.1016/j.micpath.2023.106368

PMid:37769854

Kiarashi M, et al. Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis. J Nanobiotechnology. 2024 Jan 5;22(1):21.

https://doi.org/10.1186/s12951-023-02284-5

PMid:38183090 PMCid:PMC10770920

Bolouki Far S, et al. Examination Heat Parameters and Fluid Flow between Equal Sheets Down the Influx of Hybrid Nanoparticle Suction and Injection by Akbari-Ganji Technique. heliyon. 2023; :4543493.

https://doi.org/10.2139/ssrn.4543493

Ghahjavarestani AM, et al. Study of marital satisfaction in autistic families. J Autism Dev Disord. 2020;18(2):21-31.

https://doi.org/10.17759/autdd.2020180204

Akaishi T, et al. White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. Sci Rep. 2021; 11(1): 22357.

https://doi.org/10.1038/s41598-021-01942-8

PMid:34785750 PMCid:PMC8595427

Pierson ER, et al. The contribution of neutrophils to CNS autoimmunity. J Clin Immunol. 2018; 189: 23-28.

https://doi.org/10.1016/j.clim.2016.06.017

PMid:27377536 PMCid:PMC5203971

Shoeibi M, et al. Moving Toward Resiliency in Health Supply Chain. Int J Ind Eng. 2023 Oct 18;5(3):63-74.

Morel A, et al. Relationship between the increased haemostatic properties of blood platelets and oxidative stress level in multiple sclerosis patients with the secondary progressive stage. Oxid Med Cell Longev. 2015; 2015(1):240918.

https://doi.org/10.1155/2015/240918

PMid:26064417 PMCid:PMC4429191

Pourali G, et al. Microbiome as a biomarker and therapeutic target in pancreatic cancer. BMC microbiol. 2024 Jan 5;24(1):16.

https://doi.org/10.1186/s12866-023-03166-4

PMid:38183010 PMCid:PMC10768369

Bagi M, et al. Advances in technical assessment of spiral inertial microfluidic devices toward bioparticle separation and profiling: A critical review. Biochip J. 2024 Jan 22:1-23.

https://doi.org/10.1007/s13206-023-00131-1

Lee NJ, et al. Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain. 2018; 141(6):1637-1649.

https://doi.org/10.1093/brain/awy082

PMid:29688408 PMCid:PMC5972667

Kiarashi M, et al. Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases. Stem Cell Rev. 2024 Feb 3:1-34.

https://doi.org/10.1007/s12015-024-10687-6

PMid:38308730

Jalaledin G, et al. Method for producing rod-shaped and branched metallic nano-structures by polyol compounds. U.S pat app. 2011;12:792.

Ghanavi J, et al. Method for the synthesis of metallic nano products. U.S pat app. 2016; 9487:399.

Ghalehbandi M, et al. The association between sleep quality, health status and disability due to breathlessness in chronic obstructive pulmonary disease patients. Clin Respir J. 2021 Nov;15(11):1168-74.

https://doi.org/10.1111/crj.13423

PMid:34310080

Safapoor S, et al. Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline- quinazolinone-thioacetamides. RSC Adv. 2023;13(28):19243-56.

https://doi.org/10.1039/D3RA01790G

PMid:37377867 PMCid:PMC10291282

Mollazadeh M, et al. Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic simulations. Med Chem Res. 2023 May;32(5):930-43.

https://doi.org/10.1007/s00044-023-03050-w

Downloads

Published

2024-12-31

How to Cite

Yaseliani, M., Moghadasi, A. N., Sahraian, M. A., Karimi, M., Alizadeh Vaghasloo, M., & Rezaeizadeh , H. (2024). Evaluation of Changes in Hemorheological Variables in Multiple Sclerosis Patients: Evaluation of Changes in Hemorheological Variables in Multiple Sclerosis Patients. Galen Medical Journal, 13, e3513. https://doi.org/10.31661/gmj.v13i.3513

Issue

Section

Review Article