Growth Factors, Signaling Pathways and other Biochemical Markers effect on Nucleotide Excision Repair (NER) Suppression in Uterine Fibroids (Leiomyomas); A Systematic Review

Growth Factors, Signaling Pathways effect on NER Suppression in Leiomyomas

Abstract

Among human malignancies, uterine fibroids (UF) rank high in frequency and severity of symptoms. Vitamins, mutant genes, growth factors, microRNAs, steroid signaling pathways, and a host of other substances can influence UF. This study set out to compile the effects of various agents, such as growth factors and signaling pathways, on nucleotide excision repair (NER) in uterine fibroids. For this review, the PRISMA guidelines were followed. The following search phrases were utilized in the PubMed, Ovid, and Cochrane Library databases: “fibroid, leiomyomata, leiomyoma, TGF-*, vitamin D, RACK 1, WNT, miR, mutant gene.” Every study, in vitro, in vivo, and clinical, was also taken into account. From January 1, 2000, to December 31, 2023, we looked for any proceedings published by the Pacific Coast Fertility Society, SGI,American Society for Reproductive Medicine, Association of Gynecologic Laparoscopists, ASRM, or ASRM. Relevance was determined by looking at titles first, and then abstracts. Full reports included an assessment of all citations that could be relevant. From the original pool of 990 studies, 24 were included in the data analysis. Methods, steroid signaling, growth factors, microRNAs, vitamins, and mutant genes were the main categories into which studies were subdivided. Proliferation of cells and an excess of disordered extracellular matrix (ECM) were identified as hallmarks of uterine leiomyomas. This pair of activities is carefully controlled by a network of signaling pathways. Furthermore, future research should employ current procedures consistently in order to conduct meta-analysis on the results. This will greatly assist in developing treatment protocols.