Resveratrol effects on male infertility
Resveratrol and Male Infertility
DOI:
https://doi.org/10.31661/gmj.v13i.3622Keywords:
Resveratrol; Male Infertility; Oxidative Stress; Inflammation; SpermAbstract
The escalating prevalence of male reproductive disorders and associated infertility has become a pressing concern, necessitating heightened awareness due to its substantial socioeconomic and psychological impact. Research has elucidated the multifaceted etiology of male infertility, encompassing oxidative stress, inflammation, and lifestyle-related factors. Resveratrol, a naturally occurring non-flavonoid polyphenol, has garnered significant attention for its potential health benefits, particularly in mitigating oxidative stress and inflammation. However, the relationship between this compound and male fertility remains poorly understood, with existing research yielding conflicting results. The current review aimed to discuss the effects of resveratrol on human male fertility and explore the underlying mechanisms by which it may influence male infertility.
References
Sun H, Gong T-T, Jiang Y-T, Zhang S, Zhao Y-H, Wu Q-J. Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990-2017: results from a global burden of disease study, 2017. Aging (Albany NY). 2019;11(23):10952.
https://doi.org/10.18632/aging.102497
Pereira SC, Oliveira PF, Oliveira SR, Pereira MdL, Alves MG. Impact of environmental and lifestyle use of chromium on male fertility: focus on antioxidant activity and oxidative stress. Antioxidants. 2021;10(9):1365.
https://doi.org/10.3390/antiox10091365
Aitken RJ, Whiting S, De Iuliis GN, McClymont S, Mitchell LA, Baker MA. Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase. J Biol Chem. 2012;287(39):33048-60.
https://doi.org/10.1074/jbc.M112.366690
Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91.
https://doi.org/10.3390/biomedicines6030091
Zhang L-X, Li C-X, Kakar MU, Khan MS, Wu P-F, Amir RM, et al. Resveratrol (RV): A pharmacological review and call for further research. Biomed pharmacother. 2021;143:112164.
https://doi.org/10.1016/j.biopha.2021.112164
Zamora-Ros R, Rothwell JA, Achaintre D, Ferrari P, Boutron-Ruault M-C, Mancini FR, et al. Evaluation of urinary resveratrol as a biomarker of dietary resveratrol intake in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr. 2017;117(11):1596-602.
https://doi.org/10.1017/S0007114517001465
Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinol. 2000;141(10):3657-67.
https://doi.org/10.1210/endo.141.10.7721
Gehm BD, McAndrews JM, Chien P-Y, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proceedings of the National Academy of Sciences. 1997;94(25):14138-43.
https://doi.org/10.1073/pnas.94.25.14138
Streicher W, Luedeke M, Azoitei A, Zengerling F, Herweg A, Genze F, et al. Stilbene induced inhibition of androgen receptor dimerization: implications for AR and ARΔLBD-signalling in human prostate cancer cells. PLoS One. 2014;9(6):e98566.
https://doi.org/10.1371/journal.pone.0098566
Lee M-H, Kundu JK, Keum Y-S, Cho Y-Y, Surh Y-J, Choi BY. Resveratrol inhibits IL-6-induced transcriptional activity of AR and STAT3 in human prostate cancer LNCaP-FGC cells. Biomol Ther. 2014;22(5):426.
https://doi.org/10.4062/biomolther.2014.061
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell metab. 2012;15(5):675-90.
https://doi.org/10.1016/j.cmet.2012.04.003
Shabani Nashtaei M, Amidi F, Sedighi Gilani M, Aleyasin A, Bakhshalizadeh S, Naji M, Nekoonam S. Protective features of resveratrol on human spermatozoa cryopreservation may be mediated through 5'AMP-activated protein kinase activation. Andrology. 2017;5(2):313-26.
https://doi.org/10.1111/andr.12306
Yun H, Park S, Kim MJ, Yang WK, Im DU, Yang KR, et al. AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. The FEBS journal. 2014;281(19):4421-38.
https://doi.org/10.1111/febs.12949
Illiano E, Trama F, Zucchi A, Iannitti RG, Fioretti B, Costantini E. Resveratrol-based multivitamin supplement increases sperm concentration and motility in idiopathic male infertility: a pilot clinical study. J clin med. 2020;9(12):4017.
https://doi.org/10.3390/jcm9124017
Collodel G, Federico MG, Geminiani M, Martini S, Bonechi C, Rossi C, et al. Effect of trans-resveratrol on induced oxidative stress in human sperm and in rat germinal cells. Reprod Toxicol. 2011;31(2):239-46.
https://doi.org/10.1016/j.reprotox.2010.11.010
Shabani Nashtaei M, Nekoonam S, Naji M, Bakhshalizadeh S, Amidi F. Cryoprotective effect of resveratrol on DNA damage and crucial human sperm messenger RNAs, possibly through 5′ AMP-activated protein kinase activation. Cell tissue bank. 2018;19:87-95.
https://doi.org/10.1007/s10561-017-9642-5
Martinez J, Moreno JJ. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochemical pharmacology. 2000;59(7):865-70.
https://doi.org/10.1016/S0006-2952(99)00380-9
Barati E, Nikzad H, Karimian M. Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. Cellular and Molecular Life Sciences. 2020;77:93-113.
https://doi.org/10.1007/s00018-019-03253-8
Cheng L, Yan B, Chen K, Jiang Z, Zhou C, Cao J, et al. Resveratrol-induced downregulation of NAF-1 enhances the sensitivity of pancreatic cancer cells to gemcitabine via the ROS/Nrf2 signaling pathways. Oxid Med Cell Longev. 2018;2018(1):9482018.
https://doi.org/10.1155/2018/9482018
Gao Y, Fu R, Wang J, Yang X, Wen L, Feng J. Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathway. Pharm Biol. 2018;56(1):440-9.
https://doi.org/10.1080/13880209.2018.1502326
Kong F, Zhang R, Zhao X, Zheng G, Wang Z, Wang P. Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through COX-2 expression. Korean J Physiol Pharmacol. 2017;21(5):465-74.
https://doi.org/10.4196/kjpp.2017.21.5.465
Fuggetta MP, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali-Fei P, et al. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. J Exp Clin Cancer Res. 2016;35:1-9.
https://doi.org/10.1186/s13046-016-0398-8
Adhami VM, Afaq F, Ahmad N. Suppression of ultraviolet B exposure-mediated activation of NF-κB in normal human keratinocytes by resveratrol. Neoplasia. 2003;5(1):74-82.
https://doi.org/10.1016/S1476-5586(03)80019-2
Yi H, Zhang W, Cui Z-M, Cui S-Y, Fan J-B, Zhu X-H, Liu W. Resveratrol alleviates the interleukin-1β-induced chondrocytes injury through the NF-κB signaling pathway. J Orthop Surg Res. 2020;15:1-9.
https://doi.org/10.1186/s13018-020-01944-8
Francisco CM, Fischer LW, Vendramini V, de Oliva SU, Paccola CC, Miraglia SM. Resveratrol reverses male reproductive damage in rats exposed to nicotine during the intrauterine phase and breastfeeding. Andrology. 2022;10(5):951-72.
https://doi.org/10.1111/andr.13183
Wang KL, Chiang YF, Huang KC, Chen HY, Ali M, Hsia SM. Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention. Ecotoxicol Environ Saf. 2024;271:115978.
https://doi.org/10.1016/j.ecoenv.2024.115978
Simas JN, Mendes TB, Fischer LW, Vendramini V, Miraglia SM. Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes. Andrology. 2021;9(1):384-99.
https://doi.org/10.1111/andr.12891
Baazm M, Babaei R, Fathi AN, Karami H, Bayat M. Resveratrol ameliorates spermatogenesis by increasing protamine 1, 2 and HSPA2 expression in experimental varicocele rat model. Revista internacional de andrologia. 2023;21(4):100370.
https://doi.org/10.1016/j.androl.2023.100370
Singh I, Goyal Y, Ranawat P. Potential chemoprotective role of resveratrol against cisplatin induced testicular damage in mice. Chem Biol Interact. 2017;273:200-11.
https://doi.org/10.1016/j.cbi.2017.05.024
Hassanin HM, Kamal AA, Ismail OI. Resveratrol ameliorates atrazine-induced caspase-dependent apoptosis and fibrosis in the testis of adult albino rats. Sci rep. 2024;14(1):17743.
https://doi.org/10.1038/s41598-024-67636-z
Özatik FY, Özatik O, Yiğitaslan S, Ünel Ç, Erol K. Protective role of resveratrol on testicular germ cells in mice with testicular toxicity. Turk j urol. 2017;43(4):444-50.
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