A Narrative Review on Biologic Joint Therapy in Chronic Bilateral Mandibular Luxation

A Review on Biologic Joint Therapy in Chronic Bilateral Mandibular Luxation

Authors

  • Seyed Hossein Shahidi Department of Oral & Maxillo Facial Surgery, School of Dentistry, Islamic Azad University of Shiraz, Shiraz, Iran
  • Sadaf Ghasemzadeh Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, Iran
  • Sayeh Zarehgar Department of Prosthodontics, School of Dentistry, Unciano Colleges and General Hospital, Manila, Philipines
  • Nader Ghotbi Isfahan Azad University, School of Dentistry, Isfahan, Iran
  • Fatemeh Bagherian Moscow State University of Medicine and Dentistry, Moscow, Russia
  • Reza Mahmoudi Anzabi Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Meysam Mohammadikhah Department of Oral and Maxillofacial Surgery, School of Dentistry, Alborz University of Medical Sciences, Karaj, Alborz, Iran
  • Nima Ahangar Atashi Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, Iran

DOI:

https://doi.org/10.31661/gmj.v13iSP1.3645

Keywords:

Temporomandibular Joint; Luxation; Dislocation; Platelet-Rich Plasma; Hyaluronic Acid; Autologous Blood Injection

Abstract

Background: Temporomandibular joint (TMJ) luxation, or dislocation, is a relatively infrequent but highly consequential condition that requires prompt medical attention. This narrative review strives to offer a thorough summary of TMJ luxation treatment modalities, with a focus on recent advancements in biological treatments. Materials and Methods: A narrative review was conducted by synthesizing data from various sources, including systematic reviews, meta-analyses, and clinical trials. The review covers studies published up to 2024. Results: Various surgical techniques, such as eminectomy, midline mandibulotomy, and extended prosthetic total TMJ reconstruction (eTMJR), have been used to treat chronic TMJ dislocation. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have shown promise in treating TMJ disorders. PRP can promote healing and reduce inflammation, while HA improves mandibular mobility and reduces pain. A combination of HA and PRP has been found to be particularly effective in treating TMJ disorders. Autologous blood injection (ABI) has been shown to be effective in reducing the recurrence of dislocation and improving patient outcomes, with fewer side effects compared to other treatments. Conclusion: TMJ luxation is a multifactorial condition that requires prompt and appropriate management to prevent long-term complications. While various surgical techniques are available, biological treatments such as PRP, HA, and ABI have shown promising results, particularly in reducing pain and improving joint function. Further research, including randomized controlled trials, is required to ascertain the most efficacious therapy modalities and to refine clinical guidelines for the management of TMJ luxation.

References

Landes CA, Lipphardt R. Prospective evaluation of a pragmatic treatment rationale: Open reduction and internal fixation of displaced and dislocated condyle and condylar head fractures and closed reduction of non-displaced, non-dislocated fractures Part I: Condyle and sub condylar fractures. Int J Oral Maxillofac Surg. 2005;34:859-70.

https://doi.org/10.1016/j.ijom.2005.04.021

PMid:15979851

Caminiti MF, Weinberg S. Chronic mandibular dislocation: The role of non-surgical and surgical treatment. J Can Dent Assoc. 1998;64:484-91.

Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A. Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: recommendations of the International RDC/TMD Consortium Network and Orofacial Pain Special Interest Group. Journal of oral & facial pain and headache. 2014;28(1):6.

https://doi.org/10.11607/jop.1151

PMid:24482784 PMCid:PMC4478082

Ruiz S, Lim R. Spontaneous temporomandibular joint dislocation. Journal of Craniofacial Surgery. 2019 May 1;30(3):e265-7.

https://doi.org/10.1097/SCS.0000000000005309

PMid:31048623

Cascone P, Ungari C, Paparo F, Marianetti TM, Ramieri V, Fatone MG. A new surgical approach for the treatment of chronic recurrent temporomandibular joint dislocation. Journal of Craniofacial Surgery. 2008 Mar 1;19(2):510-2.

https://doi.org/10.1097/SCS.0b013e318163e42f

PMid:18362734

Ugboko VI, Oginni FO, Ajike SO, Olasoji HO, Adebayo ET. A survey of temporomandibular joint dislocation: aetiology, demographics, risk factors and management in 96 Nigerian cases. International journal of oral and maxillofacial surgery. 2005 Jul 1;34(5):499-502.

https://doi.org/10.1016/j.ijom.2004.10.025

PMid:16053868

Valesan LF, Da-Cas CD, Réus JC, Denardin AC, Garanhani RR, Bonotto D, Januzzi E, de Souza BD. Prevalence of temporomandibular joint disorders: a systematic review and meta-analysis. Clinical oral investigations. 2021 Feb;25:441-53.

https://doi.org/10.1007/s00784-020-03710-w

PMid:33409693

Prechel U, Ottl P, Ahlers OM, Neff A. The treatment of temporomandibular joint dislocation: A systematic review. Deutsches Aerzteblatt International. 2018 Feb;115(5):59.

https://doi.org/10.3238/arztebl.2018.0059

PMid:29439762 PMCid:PMC5817180

Qiao YM, Liu YM, Li R, Gong JM, He W. Retrospective study of temporomandibular joint dislocation by surgical treatment. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology. 2018 Jun 1;36(3):262-6.

Liddell A, Perez DE. Temporomandibular joint dislocation. Oral and Maxillofacial Surgery Clinics. 2015 Feb 1;27(1):125-36.

https://doi.org/10.1016/j.coms.2014.09.009

PMid:25483448

Ugboko VI, Oginni FO, Ajike SO, Olasoji HO, Adebayo ET. A survey of temporomandibular joint dislocation: aetiology, demographics, risk factors and management in 96 Nigerian cases. International journal of oral and maxillofacial surgery. 2005 Jul 1;34(5):499-502.

https://doi.org/10.1016/j.ijom.2004.10.025

PMid:16053868

Güven O. Management of chronic recurrent temporomandibular joint dislocations: a retrospective study. Journal of Cranio-Maxillofacial Surgery. 2009 Jan 1;37(1):24-9.

https://doi.org/10.1016/j.jcms.2008.08.005

PMid:18996023

Sato J, Segami N, Nishimura M, Suzuki T, Kaneyama K, Fujimura K. Clinical evaluation of arthroscopic eminoplasty for habitual dislocation of the temporomandibular joint: comparative study with conventional open eminectomy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2003; 95(4):390-395.

https://doi.org/10.1067/moe.2003.128

PMid:12686922

Anbumani P, Ashwin V, Narwade PU, Manikandan M. Management Strategy for Chronic Recurrent Temporomandibular Joint Dislocation: A Prospective Study. Indian Journal of Otolaryngology and Head & Neck Surgery. 2022 Oct 2:1-6.

Iizuka T, Hidaka Y, Murakami KI, Nishida M. Chronic recurrent anterior luxation of the mandible: A review of 12 patients treated by the LeClerc procedure. International journal of oral and maxillofacial surgery. 1988 Jun 1;17(3):170-2.

https://doi.org/10.1016/S0901-5027(88)80024-9

PMid:3135342

Srivastava D, Rajadnya M, Chaudhary MK, Srivastava JL. The Dautrey procedure in recurrent dislocation: a review of 12 cases. International journal of oral and maxillofacial surgery. 1994 Aug 1;23(4):229-31.

https://doi.org/10.1016/S0901-5027(05)80376-5

PMid:7798695

Rattan V, Rai S, Sethi A. Midline mandibulotomy for reduction of long-standing temporomandibular joint dislocation. Craniomaxillofacial Trauma & Reconstruction. 2013 Jun;6(2):127-31.

https://doi.org/10.1055/s-0033-1343786

PMid:24436748 PMCid:PMC3721015

Wroclawski C, Mediratta JK, Fillmore WJ. Recent advances in temporomandibular joint surgery. Medicina. 2023 Aug 2;59(8):1409.

https://doi.org/10.3390/medicina59081409

PMid:37629699 PMCid:PMC10456345

Tocaciu S, McCullough MJ, Dimitroulis G. Surgical management of recurrent TMJ dislocation-a systematic review. Oral and maxillofacial surgery. 2019 Mar 6;23:35-45.

https://doi.org/10.1007/s10006-019-00746-5

PMid:30729355

Bahgat MM, Abdel-Hamid AM. Is dextrose prolotherapy beneficial in the management of temporomandibular joint internal derangement A systematic review. CRANIO®. 2023 Apr 26:1-9.

https://doi.org/10.1080/08869634.2023.2204042

PMid:37097125

Alvarez C, Monasterio G, Cavalla F, Córdova LA, Hernández M, Heymann D, Garlet GP, Sorsa T, Pärnänen P, Lee HM, Golub LM. Osteoimmunology of oral and maxillofacial diseases: translational applications based on biological mechanisms. Frontiers in Immunology. 2019 Jul 18;10:1664.

https://doi.org/10.3389/fimmu.2019.01664

PMid:31379856 PMCid:PMC6657671

Acri TM, Shin K, Seol D, Laird NZ, Song I, Geary SM, Chakka JL, Martin JA, Salem AK. Tissue engineering for the temporomandibular joint. Advanced healthcare materials. 2019 Jan;8(2):1801236.

https://doi.org/10.1002/adhm.201801236

PMid:30556348 PMCid:PMC7075314

White T, Hedderick V, Ramponi DR. Dislocation of the temporomandibular joint and relocation procedures. Advanced Emergency Nursing Journal. 2016 Jul 1;38(3):177-82.

https://doi.org/10.1097/TME.0000000000000110

PMid:27482989

Zamorano GM, Nuñez LF, Alvarez LA, Otayza FA, Fernández MA, Donoso-Hofer F. Temporomandibular joint ankylosis after condylar dislocation into the middle cranial fossa: A case report. Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale. 2016 Nov 1;117(5):351-6.

https://doi.org/10.1016/j.revsto.2016.06.001

PMid:27473929

Chęciński M, Chlubek D, Sikora M. Effects of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) on Mandibular Mobility in Temporomandibular Joint Disorders: A Controlled Clinical Trial. Biomolecules. 2024 Sep 26;14(10):1216.

https://doi.org/10.3390/biom14101216

PMid:39456149 PMCid:PMC11505905

Chęciński M, Lubecka K, Bliźniak F, Chlubek D, Sikora M. Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review. International Journal of Molecular Sciences. 2024 Aug 29;25(17):9401.

https://doi.org/10.3390/ijms25179401

PMid:39273351 PMCid:PMC11395054

Sane VD, Sunil Nair V, Jadhav R, Sane R, Kadam P, Patil R. Comparative Evaluation of Efficacy of Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) in Bone Regeneration after Surgical Removal of Impacted Bilateral Mandibular Third Molars-A Comparative Study. Indian Journal of Otolaryngology and Head & Neck Surgery. 2024 Feb;76(1):811-8.

https://doi.org/10.1007/s12070-023-04285-0

PMid:38440518 PMCid:PMC10908979

Aishwarya K, Rai M. Injectable Platelet-Rich Fibrin: A Promising First-Line Therapy for Temporomandibular Joint Hypermobility. Journal of Maxillofacial and Oral Surgery. 2024 Nov 29:1-0.

https://doi.org/10.1007/s12663-024-02389-w

Alsaadi AA, Elmohandes W, Elfeky AH. Evaluation of Effect of Intraarticular Injection of Chitosan-Hyaluronate Gel Mixture Vs Hyaluronic Acid in Management of TMJ Internal Derangement. Al-Azhar Journal of Dental Science. 2024 Oct 1;27(4):549-59.

https://doi.org/10.21608/ajdsm.2023.194666.1421

Chęciński M, Chlubek D, Sikora M. Effects of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) on Mandibular Mobility in Temporomandibular Joint Disorders: A Controlled Clinical Trial. Biomolecules. 2024 Sep 26;14(10):1216.

https://doi.org/10.3390/biom14101216

PMid:39456149 PMCid:PMC11505905

Xu J, Ren H, Zhao S, Li Q, Li C, Bao G, Kang H. Comparative effectiveness of hyaluronic acid, platelet-rich plasma, and platelet-rich fibrin in treating temporomandibular disorders: A systematic review and network meta-analysis. Head & Face Medicine. 2023 Aug 26;19(1):39.

https://doi.org/10.1186/s13005-023-00369-y

PMid:37633896 PMCid:PMC10463486

Aryaei A, Vapniarsky N, Hu JC, Athanasiou KA. Recent tissue engineering advances for the treatment of temporomandibular joint disorders. Current osteoporosis reports. 2016 Dec;14:269-79.

https://doi.org/10.1007/s11914-016-0327-y

PMid:27704395 PMCid:PMC5106310

Sikora M, Sielski M, Chęciński M, Nowak Z, Czerwińska-Niezabitowska B, Chlubek D. Repeated intra-articular administration of platelet-rich plasma (PRP) in temporomandibular disorders: a clinical case series. Journal of Clinical Medicine. 2022 Jul 22;11(15):4281.

https://doi.org/10.3390/jcm11154281

PMid:35893369 PMCid:PMC9331867

Fayed HM, Ahmed WA. Autologous Blood Injection versus Eminectomy in management of Chronic Recurrent Temporomandibular Joint Dislocation. Egyptian Dental Journal. 2024 Oct 1;70(4):3165-72.

https://doi.org/10.21608/edj.2024.301043.3100

Chhapane A, Wadde K, Sachdev SS, Barai S, Landge J, Wadewale M. Comparison of Autologous Blood Injection and Dextrose Prolotherapy in the Treatment of Chronic Recurrent Temporomandibular Dislocation: A Randomized Clinical Trial. Journal of Maxillofacial and Oral Surgery. 2024 Apr;23(2):278-84.

https://doi.org/10.1007/s12663-023-01848-0

PMid:38601242

Noha M, Youssef WM. Comparative study between Autologous Blood Injection and Botulinum toxin in the treatment of Chronic Recurrent Temporomandibular Joint Dislocation. Afr J Bio Sc. 2024:6(9):183-190.

Coser R, Da Silveira H, Medeiros P, Ritto FG. Autologous blood injection for the treatment of recurrent mandibular dislocation. International journal of oral and maxillofacial surgery. 2015 Aug 1;44(8):1034-7.

https://doi.org/10.1016/j.ijom.2015.05.004

PMid:26022511

Hasson O, Nahlieli O. Autologous blood injection for treatment of recurrent temporomandibular joint dislocation. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2001 Oct 1;92(4):390-3.

https://doi.org/10.1067/moe.2001.116602

PMid:11598572

Varedi P, Bohluli B. Autologous blood injection for treatment of chronic recurrent TMJ dislocation: is it successful Is it safe enough A systematic review. Oral and maxillofacial surgery. 2015 Sep;19:243-52.

https://doi.org/10.1007/s10006-015-0500-y

PMid:25934244

Chęciński M, Chęcińska K, Rąpalska I, Turosz N, Chlubek D, Sikora M. Autologous blood injections in temporomandibular hypermobility: a systematic review. Journal of Clinical Medicine. 2023 Aug 27;12(17):5590.

https://doi.org/10.3390/jcm12175590

PMid:37685657 PMCid:PMC10488723

Chhapane A, Wadde K, Sachdev SS, Barai S, Landge J ,Wadewale M. Comparison of Autologous Blood Injection and Dextrose Prolotherapy in the Treatment of Chronic Recurrent Temporomandibular Dislocation: A Randomized Clinical Trial. Journal of Maxillofacial and Oral Surgery. 2024;23(2):278-284.

https://doi.org/10.1007/s12663-023-01848-0

PMid:38601242

Yoshida K, Iizuka T. Botulinum toxin treatment for upper airway collapse resulting from temporomandibular joint dislocation due to jaw-opening dystonia. CRANIO®. 2006 Jul 1;24(3):217-22.

https://doi.org/10.1179/crn.2006.035

PMid:16933464

Akbay E, Cevik C, Damlar I, Altan A. Treatment of displaced mandibular condylar fracture with botulinum toxin A. Auris Nasus Larynx. 2014 Apr 1;41(2):219-21.

https://doi.org/10.1016/j.anl.2013.08.002

PMid:24156980

Yoshida K. Botulinum neurotoxin injection for the treatment of recurrent temporomandibular joint dislocation with and without neurogenic muscular hyperactivity. Toxins. 2018 Apr 25;10(5):174.

https://doi.org/10.3390/toxins10050174

PMid:29693593 PMCid:PMC5983230

Oztel M, Bilski WM, Bilski A. Botulinum toxin used to treat recurrent dislocation of the temporomandibular joint in a patient with osteoporosis. British Journal of Oral and Maxillofacial Surgery. 2017 Jan 1;55(1):e1-2.

https://doi.org/10.1016/j.bjoms.2016.05.012

PMid:27256802

Teemul TA, Patel R, Kanatas A, Carter LM. Management of oromandibular dystonia with botulinum A toxin: a series of cases. British Journal of Oral and Maxillofacial Surgery. 2016 Dec 1;54(10):1080-4.

https://doi.org/10.1016/j.bjoms.2016.06.028

PMid:27776922

Lee ST, Kim D, Park JH, Kwon TG. Ultrasound-guided intraoral botulinum toxin injection into the lateral pterygoid muscle for chronic temporomandibular joint dislocation. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2024 Feb 2;50(1):41.

https://doi.org/10.5125/jkaoms.2024.50.1.41

PMid:38419520 PMCid:PMC10910006

Wojtovicz EL, Alvarez OM, Lopez-Davis A, Armijo-Olivo S. Botulinum toxin type A injection into the masticatory muscles and its effects on mandibular bone resorption and density A systematic review. Clinical Oral Investigations. 2024 Aug 9;28(9):477.

https://doi.org/10.1007/s00784-024-05838-5

PMid:39123075

Ban A, Roman R, Bran S, Băciuț M, Dinu C, Crasnean E, Almășan O, Hedeșiu M. Botulinum Toxin Injection into the Digastric Muscle: Current Clinical Use and a Report of Five Cases. Biomedicines. 2023 Oct 12;11(10):2767.

https://doi.org/10.3390/biomedicines11102767

PMid:37893140 PMCid:PMC10604337

Ziegler CM, Haag C, Mühling J. Treatment of recurrent temporomandibular joint dislocation with intramuscular botulinum toxin injection. Clinical oral investigations. 2003 Mar;7:52-5.

https://doi.org/10.1007/s00784-002-0187-y

PMid:12673439

Fu KY, Chen HM, Sun ZP, Zhang ZK, Ma XC. Long-term efficacy of botulinum toxin type A for the treatment of habitual dislocation of the temporomandibular joint. British Journal of Oral and Maxillofacial Surgery. 2010 Jun 1;48(4):281-4.

https://doi.org/10.1016/j.bjoms.2009.07.014

PMid:19665263

Ferreira EF, Camões-Barbosa A. IncobotulinumtoxinA in refractory temporomandibular disorder due to disk dislocation: A prospective study. Journal of Stomatology, Oral and Maxillofacial Surgery. 2024 Feb 26:101804.

https://doi.org/10.1016/j.jormas.2024.101804

PMid:38412921

Bouso OV, González GF, Mommsen J, Grau VG, Fernández JR , Micas MM. Neurogenic temporomandibular joint dislocation treated with botulinum toxin: report of 4 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2010; 109(3):e33-e37.

https://doi.org/10.1016/j.tripleo.2009.10.046

PMid:20219583

Downloads

Published

2024-12-25

How to Cite

Shahidi, S. H., Ghasemzadeh, S., Zarehgar, S., Ghotbi, N., Bagherian, F., Mahmoudi Anzabi, R., … Ahangar Atashi, N. (2024). A Narrative Review on Biologic Joint Therapy in Chronic Bilateral Mandibular Luxation: A Review on Biologic Joint Therapy in Chronic Bilateral Mandibular Luxation. Galen Medical Journal, 13(SP1), e3645. https://doi.org/10.31661/gmj.v13iSP1.3645

Issue

Vol. 13 No. SP1 (2024): Oral and Maxillofacial Disorders

Section

Review Article

License

Copyright (c) 2024 Galen Medical Journal

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

https://creativecommons.org/licenses/by/4.0/