Exploring the Intersection of Diabetes and Musculoskeletal Health

Authors

  • Morteza Nakhaei Amroodi Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Khatere Mokhtari Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  • Pouria Tabrizian Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Keywords:

Diabetes; Orthopedic; Rotator Cuff Tear; Muscle Atrophy; Frozen Shoulder; Osteoarthritis; AGEs; Achilles Tendons; Tendon Healing; Muscle Atrophy; Rheumatoid Arthritis

Abstract

Diabetes presents a significant health challenge worldwide, with profound implications extending beyond glycemic control to impact various bodily systems. This review explores the intricate relationship between diabetes and musculoskeletal disorders, shedding light on their epidemiology, pathophysiology, and clinical implications. Individuals with diabetes face a heightened risk of developing musculoskeletal conditions, particularly tendon disorders such as adhesive capsulitis rozen shoulder, rotator cuff tears, muscle atrophy, osteoarthritis and diabetic hand syndrome. Mechanisms underlying these disorders include inflammation, glycation, and impaired tendon homeostasis, exacerbated by factors like insulin resistance and oxidative stress. Furthermore, diabetes poses challenges in orthopedic surgery, leading to increased rates of surgical complications and poorer outcomes. Understanding the interplay between diabetes and musculoskeletal health is crucial for developing targeted interventions aimed at optimizing patient care and outcomes in this population.

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2025-11-05

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Nakhaei Amroodi, M., Khatere Mokhtari, & Tabrizian, P. (2025). Exploring the Intersection of Diabetes and Musculoskeletal Health. Galen Medical Journal, 14, e3884. Retrieved from https://journals.salviapub.com/index.php/gmj/article/view/3884

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