Analgesic Medicinal Plants in Shahrekord, Southwest of Iran: An Ethnobotanical Study

Authors

  • Gholam Basati Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
  • Saber Abbaszadeh 1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran 2. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran 3. Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Hassan Teimouri Department of Anesthesiology, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Arqavan Zebardast Student Research Committee, Babol University of Medical Sciences, Babol, Iran

DOI:

https://doi.org/10.31661/gmj.v8i.1593

Keywords:

Herbal Medicine, Sedatives, Ethnobotany, Shahrekord, Iran

Abstract

Background: Identification of indigenous medicinal plants, including the gathering of information regarding the uses of these plants can help find out their traditional pharmacological activities and their benefits for the community’s healthcare system. In this study, an ethnobotanical investigation was conducted in Shahrekord city, southwest of Iran to indicate the ethnobotanical knowledge about analgesic medicinal plants in the region and the methods of using them. Materials and Methods: To this end, plant antioxidants and analgesic medicinal plants were identified. For this purpose, a questionnaire was used to obtain indigenous knowledge from traditional therapists in Shahrekord regarding pain relief using medicinal plants. This ethnobotanical study was conducted in 2018 with the participation of 29 traditional therapists of the region under purpose. Finally, the data drawn from the questionnaires were analyzed using the Excel software. The frequency of plants use was also calculated. Results: Our study showed that in Shahrekord, 23 species of medicinal plants are used to relieve pain. The highest frequency of use was obtained for Eugenia caryophylata (44%), followed by Alhagi maurorum (31%), Tribulus terrestris (27%), and angustifolia (24%). The Laminaceae family (7 species) was the most frequently used plant family for pain relief. The most frequently used plant organ to relieve the pain was flower (25%), followed by the stem (22%) and leaves (19%). Conclusion: Given the high importance of medicinal plants in Shahrekord, the results of this study and additional scientific investigations can help produce more effective and less harmful drugs from medicinal plants. [GMJ.2019;8:e1593]

References

Johnson MI, Elzahaf RA, Tashani OA. The prevalence of chronic pain in developing countries. Pain Manag. 2013; 3(2):83-6. https://doi.org/10.2217/pmt.12.83PMid:24645989 Hoofwijk DM, Fiddelers AA, Peters ML, Stessel B, Kessels AG, Joosten EA. Prevalence and predictive factors of chronic postsurgical pain and poor global recovery 1 year after outpatient surgery. Clin J Pain. 2015; 31: 1017-1025. https://doi.org/10.1097/AJP.0000000000000207PMid:25565589 Thomson S. Failed back surgery syndrome - definition, epidemiology and demographics. Br J Pain. 2013; 7: 56-59. https://doi.org/10.1177/2049463713479096PMid:26516498 PMCid:PMC4590156 Fletcher D, Stamer UM, Pogatzkiâ€Zahn E, Zaslansky R, Tanase NV, Perruchoud C. Chronic postsurgical pain in Europe: an observational study. Eur J Anaesthesiol. 2015; 32: 725-734. https://doi.org/10.1097/EJA.0000000000000319PMid:26241763 Tseli E, Boersma K, StÃ¥lnacke BM, Enthoven P, Gerdle B, Björn O. Äng, Wilhelmus A, Grooten JA. Prognostic Factors for Physical Functioning After Multidisciplinary Rehabilitation in Patients With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis. Clin J Pain. 2019; 35(2): 148-173. https://doi.org/10.1097/AJP.0000000000000669PMid:30371517 PMCid:PMC6343958 Leadley RM, Armstrong N, Reid KJ, Allen A, Misso KV, Kleijnen J. Healthy aging in relation to chronic pain and quality of life in Europe. Pain Pract. 2014; 14: 547-558. https://doi.org/10.1111/papr.12125PMid:24138082 Wallwork RS, Chipidza FE, Stern TA. Obstacles to the prescription and use of opioids. Prim Care Comp CNS Disord. 2016; 181:10.4088. https://doi.org/10.4088/PCC.15f01900 Schmidtko A, Angioni C, Kuczka K, Schmidt H, Geisslinger G. Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia. Pain. 2009;147:116-121. https://doi.org/10.1016/j.pain.2009.08.018PMid:19762153 Gil JS. Animal models of pain: progress and challenges. Nat Rev Neurosci. 2009; 10:283-294. https://doi.org/10.1038/nrn2606PMid:19259101 Valizadeh R, Veisani Y, Delpisheh A, Kikhavani S, Sohrabnejad A. Major depression and psychiatric disorders in Iranian prisoners based on a clinical interview: A systematic review and meta-analysis. Shiraz E Med J. 2017; 18(6):e44979. https://doi.org/10.5812/semj.44979 Mohammadalizadeh-Charandabi S, Rezaei N, Hakimi S, Khatami SH, valizadeh R, Azadi A. Sleep disturbances and sexual function among men aged 45-75 years in an urban area of Iran. Sleep Sci. 2016; 9(1): 29-34. https://doi.org/10.1016/j.slsci.2016.01.001PMid:27217906 PMCid:PMC4866975 Valizadeh R, Sarokhani D, Sarokhani M, Sayehmiri K, Ostovar R, Angh P, Malekzadeh M. A study of prevalence of anxiety in Iran: Systematic review and meta-analysis. Der Pharma Chem. 2016; 8(21): 48-57. Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H. Medicinal plants: past history and future perspective. J HerbMed Pharmacol. 2018;1:1-7. https://doi.org/10.15171/jhp.2018.01 Hosseini Z, Lorigooini Z, Rafieian-Kopaei M, Shirmardi HA, Solati K. A review of botany and pharmacological effect and chemical composition of Echinophora species growing in Iran. Pharmacog Rese. 2017; 9(4):305. https://doi.org/10.4103/pr.pr_22_17PMid:29263622 PMCid:PMC5717781 Bahmani M, Khaksarian M, Rafieian-Kopaei M, Abbasi N. Overview of the therapeutic effects of Origanum vulgare and Hypericum perforatum based on Iran's ethnopharmacological documents. J Clin Diag Res. 2018; 12(7): 1-4. https://doi.org/10.7860/JCDR/2018/34177.11728 Fathinezhad Z, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M. Depression and treatment with effective herbs. Curr Pharm Des. 2019 Apr 1. https://doi.org/10.2174/1381612825666190402105803PMid:30947651 Nazarian-Samani Z, Sewell RD, Lorigooini Z, Rafieian-Kopaei M. Medicinal plants with multiple effects on diabetes mellitus and its complications: A Systematic review. Current Diab Reports. 2018 1; 18(10): 72. https://doi.org/10.1007/s11892-018-1042-0PMid:30105479 Bahmani M, Taherikalani M, Khaksarian M, Rafieian-Kopaei M, Ashrafi B, Nazer M.The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Sci OA. 2019 ;31:5(3):FSO371. https://doi.org/10.4155/fsoa-2018-0096PMid:30906567 PMCid:PMC6426173 Moradi F, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M. Immunosuppression-lipid Metabolism Interplay and Medicinal Plants in Atherosclerosis: A Review. Curr Pharm Des. 2018; 24:1-5. https://doi.org/10.2174/1381612824666180829105309PMid:30156151 Nazer MR, Abbaszadeh S, Anbari K, Shams M. A review of the most important medicinal herbs affecting giardiasis. J HerbMed Pharmacol. 2019; 8(2):78-84. https://doi.org/10.15171/jhp.2019.13 Ghanadi K, Hasanvand A, Abbaszadeh S, Heidari-Soureshjani S, Suhan T. Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy. Plant Sci Today. 2019; 6(2): 114-122. https://doi.org/10.14719/pst.2019.6.2.514 Shokri Z, Khoshbin M, Koohpayeh A, Abbasi N, Bahmani F, Rafieian-Kopaei, M, Beyranvand F. Thyroid diseases: Pathophysiology and new hopes in treatment with medicinal plants and natural antioxidants. Int J Green Pharmacy. 2018; 12(3): 473-482. Abbasi N, Mohammadpour S, Karimi E, Aidy A, Karimi P, Azizi M, Asadollahi K. Protective effects of smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: Involvement of benzodiazepine and opioid antagonists. J Biological Regulators Homeostatic Agents. 2017; 31(3):683-689. Pirzad-Jahromi G, Imani E, Nasehi M, Shahriari A. Effect of Achillea millefolium aqueous extract on memory deficit and anxiety caused by stroke in ovariectomized rats. J HerbMed Pharmacol. 2019; 8(2):153-159. https://doi.org/10.15171/jhp.2019.24 Alami-Rostami S, Rafieirad M. The effect of hydro-alcoholic Ferulago angulata extract on locomotor activity and anxiety caused by hypoperfusion ischemia in adult male rats. J HerbMed Pharmacol. 2018;7(1):51-55. https://doi.org/10.15171/jhp.2018.09 Kravchenko I, Eberle L, Nesterkina M, Kobernik A. Pharmacotherapy of inflammatory process by ginger extract (Zingiber officinale) ointment. J HerbMed Pharmacol. 2019;8(2):101-107.. https://doi.org/10.15171/jhp.2019.16 Torki A, Khalaji-Pirbalouty V, Lorigooini Z, Rafieian-Kopaei M, Sadeghimanesh A, Rabiei Z. Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion. Brazilian J Pharmac Sci. 2018; 54(1): 3-7. https://doi.org/10.1590/s2175-97902018000117251 Rahimi-Madiseh M, Heidarian E, Kheiri S, Rafieian-Kopaei M. Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. Biomed Pharmacoth. 2017; 86: 363-7. https://doi.org/10.1016/j.biopha.2016.12.028PMid:28011384 Kazemi S, Shirzad H, Rafieian-Kopaei M. Recent Findings in Molecular Basis of Inflammation and Anti-inflammatory Plants. Curr Pharm Des. 2018; 24(14):1551-62. https://doi.org/10.2174/1381612824666180403122003PMid:29611479 Nejad ASM, Bahmani M, Shah NA, Shah SA, Rafieian-Kopaei M. Beliefs of herbal therapies of the community of the Ilam city of Ilam province, Iran. J Pharmacy Pharmacog Res. 2018; 6(4):299-317. Ghaderi H, Rafieian M, Nezhad HR. Effect of hydroalcoholic Cinnamomum zeylanicum extract on reserpine-induced depression symptoms in mice. Pharmacophore. 2018; 9(2):35-44. Bahmani M, Sarrafchi A, Shirzad H, Asgari S, Rafieian-Kopaei M. Cardiovascular Toxicity of Cyclooxygenase Inhibitors and Promising Natural Substitutes. Curr Pharm Des. 2017; 23(6):952-60. https://doi.org/10.2174/1381612822666161006144942PMid:27719647 Heidari MR, Zahedi MJ and Rezvani H: Analgesic effect of Iavandula officinalis and histopatological studies in mice: Scientific-Research J Shahed Uni. 2000; 30(7): 23-30. Miladi-Gorji H, Rashidi Pour A, Vafaei AA, Taherian AA: Opioid receptors role on anti-nociceptive effects of the aqueous extracts of Melissa Officinalis in mice: J Hormozgan Uni Med Sci. 2006;10(1) :28-23. Pahlavan Y, Sepehri GR, Afarinesh-Khaki MR, Sheibani V, EsmailPour-Bezenjani K, Pahlavan B. Intervention of Morphine and Naloxone on Analgesic Effects of Origanum vulgare Extract in Male Rat: J Ardabil Uni Med Sci. 2010, 11 (2): 142-134. Verdi J, Kamalinezhad M, Sabet-Kasaei M, Sharif SH. Analgesic effect of aqueous satureja hortensis l. seed extract in male rat. J Physiol Pharmacol. 2005; 8(2):163-168. Eidi AH, Rustaiyan M, Eidi M. Bahramian: Antinociception effects of ethanolic extract of Mentha piperita leaves in adult male mice. Iranian J Biol. 2010;23 (4): 613-621. Parvin N, Ansari Samani R, Shahinfard N, Reissi S, Alibabaie Z, A. Asgari A. Effect of alcoholic extract of Tanacetum parthenium on acute pain in rat. J Qazvin Uni Med Sci. 2012, 16 (1) :15-21 Kiasalari Z, Khalili M, Ashrafi M. Anti-nociceptive effect of alcoholic extract of henbane seed on the different phases of estrous cycle of female Rats: J Gorgan Uni Med Sci. 2010; 11 (4):1-7. Dashti-Rahmatabadi M, Vahidi-Merjardi A, Pilavaran A, Farzan F. Antinociceptive Effect of Cinnamon Extract on Formalin Induced Pain in Rat. JSSU. 2009; 17 (2): 190-199. Khalili M, Kiasalari Z, Farhadi E, Agah M. Effects of alcoholic extract of Zingiber officinalis rhizome on acute and chronic inflammation and pain in rats. Koomesh. 2010; 12 (2):159-166. Heidari MR, Asadipour A, Ghayoor M. Evaluation of analgesic and ulcerogenic effect of Methanolic extract of Matricaria Chamomilla L. J Qazvin Uni Med Sci. 2002; 5 (4) :15 23. Asadi-Samani M, Rafieian-Kopaei M, Lorigooini Z, Shirzad H. A screening of anti-breast cancer effects and antioxidant activity of twenty medicinal plants gathered from Chaharmahal va Bakhtyari province, Iran. J Pharm Pharmacogn Res. 2019; 7(3): 213-222. Hosseinzadeh-Samani B, Lorigooini Z, Rostami S, Zareiforoush H, Behruzian M, Behruzian A. The simultaneous effect of electromagnetic and ultrasound treatments on Escherichia coli count in red grape juice. J HerbMed Pharmacol. 2018; 7(1):29-36. https://doi.org/10.15171/jhp.2018.06 Farzan B, Abbaszadeh S, Basati G, Teimouri H. An overview of the most important medicinal plants effective on the strength of memory and mind in Iranian ethnobotany. J Pharm Pharmacogn Res. 2019; 7(3): 156-162.

Additional Files

Published

2019-09-18

Issue

Section

Original Article