Role of Herbal Plants for Treatment of Coronary Artery Disease; A Review

Authors

  • Leila Azizkhani Clinical Care Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Sharareh Jahangiri Department of Anesthesiology, Tehran University of Medical Science, Tehran, Iran
  • Seyedeh Mahya Dehestani Manchester University, United Kingdom
  • Hamid Hojati Department of Nursing, Golestan University of Medical Sciences, Gorgan, Iran
  • Yahya Ebrahimi Department of Cardiology, School of Medicine, Shahid Madani Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran

DOI:

https://doi.org/10.31661/gmj.v14i.3737

Keywords:

Cardiovascular Diseases; Medicinal Plants; Coronary Artery Disease; Sedatives; Anti-Anxiety Agents

Abstract

Background: Chronic stress is recognized as a significant risk factor for cardiovascular disease and can worsen the condition of patients with coronary artery disease (CAD). Traditional medicine is used to reduce stress and manage various diseases, with a particular focus on cardiovascular health. This study aimed to investigate the role of herbal supplements in the management of coronary artery disease, focusing on their potential to alleviate symptoms, enhance heart health, and reduce the risk of cardiovascular complications in CAD patients, alongside the mechanisms of action underlying their effects. Materials and Methods: This comprehensive review evaluates the impact of medicinal plants on stress and cardiovascular disease in research and studies with coronary artery disease. Scientific articles were sourced from databases including PubMed, Google Scholar, SID, and ScienceDirect, focusing on publications from 2000 to 2024. The selection criteria encompassed research and studies involving various dosages of medicinal plants under different conditions. Only articles in Persian and English were included, excluding those in other languages. Data from the selected articles were extracted, specifically focusing on medicinal plants effective as cardiac tonics within different regions of Iran. Results: The findings indicate that various medicinal plants, including marjoram (Origanum majorana), borage (Borago officinalis), lavender (Lavandula angustifolia), valerian (Valeriana officinalis), hops (Humulus lupulus), hawthorn (Crataegus spp.), rosemary (Rosmarinus officinalis), chamomile (Matricaria chamomilla), dracocephalum (Dracocephalum moldavica), mint (Mentha spp.), green tea (Camellia sinensis), and damask rose (Rosa damascena), have been employed for stress relief and the management of CAD, particularly in the context of mitigating cardiovascular disease risk factors. Conclusion: The combination of medicinal plants with other treatments can be an effective strategy to reduce stress and enhance cardiovascular health in coronary artery disease patients. Due to their low risk and broad therapeutic benefits, these plants can improve patients' quality of life when used alongside conventional therapies.

References

Townsend N, Kazakiewicz D, Lucy Wright F, Timmis A, Huculeci R, Torbica A, et al. Epidemiology of cardiovascular disease in Europe. Nat Rev Cardiol. 2022;19(2):133-43.

https://doi.org/10.1038/s41569-021-00607-3

PMid:34497402

Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Syndr. 2020;14(3):247-50.

https://doi.org/10.1016/j.dsx.2020.03.013

PMid:32247212 PMCid:PMC7102662

Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, et al. Explaining the decrease in US deaths from coronary disease, 1980-2000. N Engl J Med. 2007;356(23):2388-98.

https://doi.org/10.1056/NEJMsa053935

PMid:17554120

Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111(25):3481-8.

https://doi.org/10.1161/CIRCULATIONAHA.105.537878

PMid:15983262

Komilovich EB. Coronary Artery Disease. Eur J Mod Med Pract. 2023;3(12):81-7.

Hu FB, Manson JE, Willett WC. Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr. 2001;20(1):5-19.

https://doi.org/10.1080/07315724.2001.10719008

PMid:11293467

Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-23.

https://doi.org/10.1002/jcp.28350

PMid:30790284

Lovallo WR. Stress and health. Biological and psychological interactions 3rd ed Thousand Oaks: Sage Publications; 2015.

https://doi.org/10.4135/9781071801390

PMCid:PMC4869048

Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5(7):374-81.

https://doi.org/10.1038/nrendo.2009.106

PMid:19488073

Lett HS, Blumenthal JA, Babyak MA, Sherwood A, Strauman T, Robins C, et al. Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom Med. 2004;66(3):305-15.

https://doi.org/10.1097/00006842-200405000-00004

PMid:15184688

Rastogi S, Pandey MM, Rawat AKS. Traditional herbs: a remedy for cardiovascular disorders. Phytomedicine. 2016;23(11):1082-9.

https://doi.org/10.1016/j.phymed.2015.10.012

PMid:26656228

Widoyo H, Mohammed ZY, Ramírez-Coronel AA, Iswanto AH, Thattarauthodiyil U, Alkhayyat AS, et al. Herbal therapy in Covid-19: A systematic review of medicinal plants effective against Covid-19. Caspian J Environ Sci. 2023;21(5):1289-98.

Ebrahimi Y, AL-Baghdady HFA, Hameed NM, Iswanto AH, Shnain Ali M, Hammoodi HA, et al. Common fatty acids and polyphenols in olive oil and its benefits to heart and human health. Caspian J Environ Sci. 2022;():1-7.

Soltanbeigi E, Soltani M. The role of plant secondary metabolites in industry, medicine, and health care. J Biochem Phytomed. 2024;3(1):5-7.

https://doi.org/10.34172/jbp.2024.3

Jasim SA, Abdelbasset WK, Jawad MA, Bokov DO, Thangavelu L, Manouchehri A. Tramadol toxicity phytotherapy: The protective role of medicinal plants against tramadol toxicity. Caspian J Environ Sci. 2023;21(1):227-43.

Baharvand Ahmadi B, Khajoei Nejad F, Papi S, Eftekhari Z. Phytotherapy for heart tonic: An ethnobotanical study in Dehloran City, Ilam Province, Western Iran. Caspian J Environ Sci. 2023;():1-5.

Babanejad Abkenar K, Akbarzadeh A, Noori A, Niroomand M. Effect of diet containing alfalfa (Medicago sativa) powder and leaf extract on hemolymph factors of western whiteleg shrimp (Litopenaeus vannamei) under low salinity stress. Aquat Anim Nutr. 2024;10(2):1-19.

Shahzamani S, Hosseini SF, Karimi M, Khajoei Nejad F, Ghobadi R, Mazaheri Y, et al. Anticancer potential of Rhus coriaria L (Sumac): A mini review. Caspian J Environ Sci. 2023;():1-5.

Nazarbaghi S, Eftekhari Z. Herbal remedies for migraine headaches based on knowledge and ethnobotanical studies of the northern border of Iran. Plant Biotechnol Persa. 2024;6(2):8-14.

Gheitasi I, Azizi A, Omidifar N, Doustimotlagh A H. Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats. Evidence-Based Complementary and Alternative Medicine. 2020;(1): 9785932.‏

https://doi.org/10.1155/2020/9785932

Gilani AH, Bashir S, Khan AU. Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders. J Ethnopharmacol. 2007;114(3):393-399.

https://doi.org/10.1016/j.jep.2007.08.032

PMid:17900837

Souri F, Rahimi R, Shams-Ardekani MR, Amin G, Amini M, Sahebkar A. Natural lavender oil (Lavandula angustifolia) exerts cardioprotective effects against myocardial infarction by targeting inflammation and oxidative stress. Inflammopharmacology. 2019;27:799-807.

https://doi.org/10.1007/s10787-018-0520-y

PMid:30073439

Rafiee M, Kiani Z, Moezi SA, Rad GHM. The effects of lavender, valerian, and oxazepam on anxiety among hospitalized patients with coronary artery disease. Modern Care Journal. 2018; 15(1): 1-4.

https://doi.org/10.5812/modernc.68390

Haybar H, Javid AZ, Haghighizadeh MH, Valizadeh E, Mohaghegh SM, Mohammadzadeh A. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clinical nutrition ESPEN. 2018; 26: 47-52.‏

https://doi.org/10.1016/j.clnesp.2018.04.015

PMid:29908682

Abbasi M, Gohari S, Ahangar H, Bahrami M, Kamalinejad M, Reshadmanesh T, et al. Efficacy of Hawthorn Fruit Extract on Blood Pressure and Quality of Sleep in Patients with Hypertension along with Sleep Disorders: A Randomized Double-Blind Controlled Trial. Journal of Contemporary Medical Sciences. 2021; 7(4): .‏

https://doi.org/10.22317/jcms.v7i4.1017

Hassani FV, Shirani K, Hosseinzadeh H. Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review. Naunyn-Schmiedeberg's archives of pharmacology. 2016; 389:931-949.‏

https://doi.org/10.1007/s00210-016-1256-0

PMid:27178264

Nargesi S, Kordestani-Moghadam P, Pormehr M, Parivar K, Rafieian-Kopaei M. The effects of Matricaria chamomilla L hydroalcoholic extract on atherosclerotic plaques, antioxidant activity, lipid profile and inflammatory indicators in rats. Biomed Res Ther. 2018;5(10):2752-2761.

https://doi.org/10.15419/bmrat.v5i10.490

Ranjbar A, Khorami S, Safarabadi M, Shahmoradi A, Malekirad AA, Rezaie A, et al. Antioxidant activity of Iranian Echium amoenum Fisch & CA Mey flower decoction in humans: a cross-sectional before/after clinical trial. Evid Based Complement Alternat Med. 2006;3(4):469-473.

https://doi.org/10.1093/ecam/nel031

PMid:17173110 PMCid:PMC1697746

Akbari F, Rezaei M, Khatony A. Effect of peppermint essence on the pain and anxiety caused by intravenous catheterization in cardiac patients: a randomized controlled trial. Journal of pain research. 2019; 12: 2933-2939.‏

https://doi.org/10.2147/JPR.S226312

PMid:31695482 PMCid:PMC6814313

Bazyar H, Alizadeh M, Samadi M, Amani H, Salehi M. Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial. J Complement Integr Med. 2021;18(2):405-411.

https://doi.org/10.1515/jcim-2020-0090

PMid:34187117

Bikmoradi A, Khaleghverdi M, Ravangard A, Gholami F, Ghasemi M, Zand F. Impact of inhalation aromatherapy with Damask Rose (Rosa damascena) on stress, anxiety and hemodynamic parameters of patients undergoing coronary angiography: a single-blind randomized clinical trial. J Complement Integr Med. 2022;19(3):753-761.

https://doi.org/10.1515/jcim-2020-0415

PMid:34018381

Kivimäki M, Steptoe A. Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol. 2018;15(4):215-229.

https://doi.org/10.1038/nrcardio.2017.189

PMid:29213140

Fioranelli M, Bottaccioli AG, Bottaccioli F, Bianchi M, Rovesti M, Roccia MG. Stress and inflammation in coronary artery disease: a review psychoneuroendocrineimmunology-based. Front Immunol. 2018;9:2031.

https://doi.org/10.3389/fimmu.2018.02031

PMid:30237802 PMCid:PMC6135895

Mukherjee D, Palit P, Roychoudhury S, Kundu SK, Mandal SC. Role of stress in diseases and its remedial approach by herbal and natural products in stress-related disease management: experimental studies and clinical reports In: Natural Products and Drug Discovery. Elsevier. 2018; :375-410.

https://doi.org/10.1016/B978-0-08-102081-4.00014-9

Frishman WH, Beravol P, Carosella C. Alternative and complementary medicine for preventing and treating cardiovascular disease. Dis Mon. 2009;55(3):121-192.

https://doi.org/10.1016/j.disamonth.2008.12.002

PMid:19215737

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Published

2025-02-21

How to Cite

Azizkhani, L., Jahangiri, S., Dehestani, S. M., Hojati, H., & Ebrahimi, Y. (2025). Role of Herbal Plants for Treatment of Coronary Artery Disease; A Review. Galen Medical Journal, 14, e3737. https://doi.org/10.31661/gmj.v14i.3737

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Section

Review Article