Transcranial Brain Stimulation for Neurodevelopmental Disorders

Neuromodulation and Neurodevelopmental Disorders

Authors

  • Mohammad Hossein Salemi Department of Psychology, University of Tehran, Tehran, Iran

DOI:

https://doi.org/10.31661/gmj.vi.3782

Abstract

Neurodevelopmental disorders (NDDs) are characterized by cognitive, behavioral, and emotional challenges that significantly impact quality of life. Despite advances in pharmacological and behavioral interventions, many individuals exhibit partial or limited responses, highlighting the need for innovative therapeutic strategies. Non-invasive brain stimulation (NIBS) techniques, particularly transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS), have emerged as promising approaches to modulate neural circuits underlying these conditions. Beyond neural modulation, these techniques offer potential clinical benefits, such as improving cognitive and behavioral outcomes in individuals with NDDs, thereby addressing treatment gaps in conventional therapies. While TES primarily alters cortical excitability through electric fields, TMS induces direct neuronal firing via magnetic fields, allowing distinct applications tailored to specific conditions.
This review examines the mechanisms, applications, and limitations of TES, such as transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and TMS, including repetitive TMS (rTMS) and theta-burst stimulation.

References

Morris-Rosendahl DJ, Crocq MA. Neurodevelopmental disorders-the history and future of a diagnosticconcept. Dialogues Clin Neurosci. 2020 Mar 31;22(1):65-72.

https://doi.org/10.31887/DCNS.2020.22.1/macrocq

PMid:32699506 PMCid:PMC7365295

Ismail FY, Shapiro BK. What are neurodevelopmental disorders? Curr Opin Neurol. 2019 Aug;32(4):611-6.

https://doi.org/10.1097/WCO.0000000000000710

PMid:31116115

Yang Y, Zhao S, Zhang M, Xiang M, Zhao J, Chen S, et al. Prevalence of neurodevelopmental disorders among US children and adolescents in 2019 and 2020. Front Psychol. 2022 Nov 24;13:997648.

https://doi.org/10.3389/fpsyg.2022.997648

PMid:36507037 PMCid:PMC9730394

Straub L, Bateman BT, Hernandez-Diaz S, York C, Lester B, Wisner KL, et al. Neurodevelopmental Disorders Among Publicly or Privately Insured Children in the United States. JAMA Psychiatry. 2022 Mar;79(3):1-12.

https://doi.org/10.1001/jamapsychiatry.2021.3815

PMid:34985527 PMCid:PMC8733868

Kosel M, Perroud N. Neurodevelopmental Disorders: From Pathophysiology to Novel Therapeutic Approaches. Biomedicines. 2022 Mar 7;10(3):623.

https://doi.org/10.3390/biomedicines10030623

PMid:35327425 PMCid:PMC8945040

Rivera-Urbina GN, Nitsche MA, Vicario CM, Molero-Chamizo A. Applications of transcranial direct current stimulation in children and pediatrics. Rev Neurosci. 2017 Feb 1;28(2):173-84.

https://doi.org/10.1515/revneuro-2016-0045

PMid:27997354

Sabé M, Hyde J, Cramer C, Eberhard A, Crippa A, Brunoni AR, et al. Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation Across Mental Disorders: A Systematic Review and Dose-Response Meta-Analysis. JAMA Netw Open. 2024 May 22;7(5):e2412616.

https://doi.org/10.1001/jamanetworkopen.2024.12616

PMid:38776083 PMCid:PMC11112448

Yavari F, Jamil A, Mosayebi Samani M, Vidor LP, Nitsche MA. Basic and functional effects of transcranial Electrical Stimulation (tES)-An introduction. Neurosci Biobehav Rev. 2018 Feb;85:81-92.

https://doi.org/10.1016/j.neubiorev.2017.06.015

PMid:28688701

Edwards MJ, Talelli P, Rothwell JC. Clinical applications of transcranial magnetic stimulation in patients with movement disorders. Lancet Neurol. 2008 Sep 1;7(9):827-40.

https://doi.org/10.1016/S1474-4422(08)70190-X

PMid:18703005

Masuda F, Nakajima S, Miyazaki T, Tarumi R, Ogyu K, Wada M, et al. Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review. Autism. 2019 Oct;23(7):1614-29.

https://doi.org/10.1177/1362361318822502

PMid:30663323

Dyke K, Jackson G, Jackson S. Non-invasive brain stimulation as therapy: systematic review and recommendations with a focus on the treatment of Tourette syndrome. Exp Brain Res. 2022 Feb;240(2):341-63.

https://doi.org/10.1007/s00221-021-06229-y

PMid:34643763 PMCid:PMC8858270

Salehinejad MA, Wischnewski M, Nejati V, Vicario CM, Nitsche MA. Transcranial direct current stimulation in attention-deficit hyperactivity disorder: A meta-analysis of neuropsychological deficits. Avenanti A, editor PLOS ONE. 2019 Apr 12;14(4):e0215095.

https://doi.org/10.1371/journal.pone.0215095

PMid:30978259 PMCid:PMC6461252

Liu A, Gong C, Wang B, Sun J, Jiang Z. Non-invasive brain stimulation for patient with autism: a systematic review and meta-analysis. Front Psychiatry. 2023 Jun 29;14:1147327.

https://doi.org/10.3389/fpsyt.2023.1147327

PMid:37457781 PMCid:PMC10338880

Finisguerra A, Borgatti R, Urgesi C. Non-invasive Brain Stimulation for the Rehabilitation of Children and Adolescents With Neurodevelopmental Disorders. A Systematic Review: Front Psychol [Internet] 2019 Feb 6 [cited 2024 Nov 24]; Available from: https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2019.00135/full

https://doi.org/10.3389/fpsyg.2019.00135

PMid:30787895 PMCid:PMC6373438

Senkowski D, Sobirey R, Haslacher D, Soekadar SR. Boosting working memory: uncovering the differential effects of tDCS and tACS. Cereb Cortex Commun. 2022 Apr 1;3(2):tgac018.

https://doi.org/10.1093/texcom/tgac018

PMid:35592391 PMCid:PMC9113288

Jamil A, Nitsche MA. What Effect Does tDCS Have on the Brain Basic Physiology of tDCS. Curr Behav Neurosci Rep. 2017 Dec 1;4(4):331-40.

https://doi.org/10.1007/s40473-017-0134-5

Barbati SA, Podda MV, Grassi C. Tuning brain networks: The emerging role of transcranial direct current stimulation on structural plasticity. Front Cell Neurosci. 2022 Jul 21;16:945777.

https://doi.org/10.3389/fncel.2022.945777

PMid:35936497 PMCid:PMC9351051

Ratsapbhayakul T, Keeratitanont K, Chonprai C, Auvichayapat N, Suphakunpinyo C, Patjanasoontorn N, et al. Anodal transcranial direct-current stimulation and non-verbal intelligence in autism spectrum disorder: A randomized controlled trial. Dev Med Child Neurol. 2024;66(9):1244-54.

https://doi.org/10.1111/dmcn.15874

PMid:38308445

Tajadini S, Mohammadi N, Tahamtan M, Nami M. Cathodal Transcranial Direct Current Stimulation to Ameliorate the Frequency and Severity of Motor Tics: A Case Study of Tourette Syndrome. J Adv Med Sci Appl Technol. 2019 Nov 30; 4(1):21-6.

https://doi.org/10.32598/jamsat.4.1.21

Kang J, Li Y, Lv S, Hao P, Li X. Effects of transcranial direct current stimulation on brain activity and cortical functional connectivity in children with autism spectrum disorders. Front Psychiatry [Internet]: 2024 May 15 [cited 2024 Nov 24]; Available from: https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1407267/full

https://doi.org/10.3389/fpsyt.2024.1407267

PMid:38812483 PMCid:PMC11135472

Dakwar-Kawar O, Berger I, Barzilay S, Grossman ES, Cohen Kadosh R, Nahum M. Examining the effect of transcranial electrical stimulation and cognitive training on processing speed in pediatric attention deficit hyperactivity disorder: a pilot study. Front Hum Neurosci. 2022;16:791478.

https://doi.org/10.3389/fnhum.2022.791478

PMid:35966992 PMCid:PMC9363890

Moret B, Donato R, Nucci M, Cona G, Campana G. Transcranial random noise stimulation (tRNS): a wide range of frequencies is needed for increasing cortical excitability. Sci Rep. 2019 Oct 22;9(1):15150.

https://doi.org/10.1038/s41598-019-51553-7

PMid:31641235 PMCid:PMC6806007

Reed T, Cohen Kadosh R. Transcranial electrical stimulation (tES) mechanisms and its effects on cortical excitability and connectivity. J Inherit Metab Dis. 2018 Nov 1;41(6):1123-30.

https://doi.org/10.1007/s10545-018-0181-4

PMid:30006770 PMCid:PMC6326965

Barker AT, Jalinous R, Freeston IL. NON-INVASIVE MAGNETIC STIMULATION OF HUMAN MOTOR CORTEX. The Lancet. 1985 May;325(8437):1106-7.

https://doi.org/10.1016/S0140-6736(85)92413-4

PMid:2860322

Jannati A, Oberman LM, Rotenberg A, Pascual-Leone A. Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2023 Jan;48(1):191-208.

https://doi.org/10.1038/s41386-022-01453-8

PMid:36198876 PMCid:PMC9700722

King ES, Tang AD. Intrinsic Plasticity Mechanisms of Repetitive Transcranial Magnetic Stimulation. The Neuroscientist. 2024 Apr;30(2):260-74.

https://doi.org/10.1177/10738584221118262

PMid:36059273 PMCid:PMC10928958

Kwon HJ, Lim WS, Lim MH, Lee SJ, Hyun JK, Chae JH, et al. 1-Hz low frequency repetitive transcranial magnetic stimulation in children with Tourette's syndrome. Neurosci Lett. 2011 Mar 29;492(1):1-4.

https://doi.org/10.1016/j.neulet.2011.01.007

PMid:21256925

Mendes Dos Santos R, Nunes M, Peres De Souza L, Nayara De Araújo Val S, Machado Santos Á, Cristina Vieira Da Costa A, et al. Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD. Med Hypotheses. 2024 Aug;189:111411.

https://doi.org/10.1016/j.mehy.2024.111411

Shackshaft L. Mechanisms of transcranial magnetic stimulation in the treatment of anorexia nervosa. BJPsych Open. 2021 Jun 18;7(Suppl 1):S49-50.

https://doi.org/10.1192/bjo.2021.180

PMCid:PMC8771445

Silvanto J, Bona S, Marelli M, Cattaneo Z. On the Mechanisms of Transcranial Magnetic Stimulation (TMS): How Brain State and Baseline Performance Level Determine Behavioral Effects of TMS. Front Psychol. 2018;9:741.

https://doi.org/10.3389/fpsyg.2018.00741

PMid:29867693 PMCid:PMC5966578

Duan X, Yao G, Liu Z, Cui R, Yang W. Mechanisms of Transcranial Magnetic Stimulation Treating on Post-stroke Depression. Front Hum Neurosci [Internet]: 2018 May 30 [cited 2024 Nov 26]; Available from: https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2018.00215/full

https://doi.org/10.3389/fnhum.2018.00215

PMid:29899693 PMCid:PMC5988869

Ploesser M, Abraham ME, Broekman MLD, Zincke MT, Beach CA, Urban NB, et al. Electrical and Magnetic Neuromodulation Technologies and Brain-Computer Interfaces: Ethical Considerations for Enhancement of Brain Function in Healthy People - A Systematic Scoping Review. Stereotact Funct Neurosurg. 2024 Jul 10;102(5):308-24.

https://doi.org/10.1159/000539757

PMid:38986460 PMCid:PMC11457974

Hirota T, King BH. Autism Spectrum Disorder: A Review. JAMA. 2023 Jan 10;329(2):157-68.

https://doi.org/10.1001/jama.2022.23661

PMid:36625807

Maxwell CR, Villalobos ME, Schultz RT, Herpertz-Dahlmann B, Konrad K, Kohls G. Atypical Laterality of Resting Gamma Oscillations in Autism Spectrum Disorders. J Autism Dev Disord. 2015 Feb;45(2):292-7.

https://doi.org/10.1007/s10803-013-1842-7

PMid:23624928 PMCid:PMC6102725

Kayarian FB, Jannati A, Rotenberg A, Santarnecchi E. Targeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges. Autism Res. 2020;13(7):1051-71.

https://doi.org/10.1002/aur.2312

PMid:32468731 PMCid:PMC7387209

Narmashiri A, Akbari F. The Effects of Transcranial Direct Current Stimulation (tDCS) on the Cognitive Functions. A Systematic Review and Meta-analysis Neuropsychol Rev [Internet]: 2023 Dec 7 [cited 2024 Nov 26]; Available from: https://doi.org/10.1007/s11065-023-09627-x.

https://doi.org/10.1007/s11065-023-09627-x

PMid:38060075

Nazari G, Mousavi M, Sadeghi-Firoozabadi V. Effectiveness of Anodal Transcranial Direct Current Stimulation of Left Dorsolateral Prefrontal Cortex in Facial Emotion Recognition and Clinical Symptoms of Boys with Autism Spectrum Disorder. Iran J Psychiatry Behav Sci. 2023 Jun 10;18(2):e121995.

https://doi.org/10.5812/ijpbs-121995

Han YM, Chan MM, Shea CK, Mo FY, Yiu KW, Chung RC, et al. Effects of prefrontal transcranial direct current stimulation on social functioning in autism spectrum disorder: A randomized clinical trial. Autism. 2023 Nov 1;27(8):2465-82.

https://doi.org/10.1177/13623613231169547

PMid:37151094

Chan MMY, Choi CXT, Tsoi TCW, Shea CKS, Yiu KWK, Han YMY. Effects of multisession cathodal transcranial direct current stimulation with cognitive training on sociocognitive functioning and brain dynamics in autism: A double-blind, sham-controlled, randomized EEG study. Brain Stimulat. 2023 Nov;16(6):1604-16.

https://doi.org/10.1016/j.brs.2023.10.012

PMid:37918630

Hupfeld KE, Ketcham CJ. Behavioral Effects of Transcranial Direct Current Stimulation on Motor and Language Planning in Minimally Verbal Children with Autism Spectrum Disorder (ASD): Feasibility, Limitations and Future Directions. J Child Dev Disord. 2016 Jun 9;2(3):21.

https://doi.org/10.4172/2472-1786.100029

Rajaprakash M, Leppert ML. Attention-Deficit/Hyperactivity Disorder. Pediatr Rev. 2022 Mar 1;43(3):135-47.

https://doi.org/10.1542/pir.2020-000612

PMid:35229109

Salehinejad MA, Nejati V, Mosayebi-Samani M, Mohammadi A, Wischnewski M, Kuo MF, et al. Transcranial Direct Current Stimulation in ADHD: A Systematic Review of Efficacy, Safety, and Protocol-induced Electrical Field Modeling Results. Neurosci Bull. 2020 Oct;36(10):1191-212.

https://doi.org/10.1007/s12264-020-00501-x

PMid:32418073 PMCid:PMC7532240

Boetzel C, Herrmann CS. Potential targets for the treatment of ADHD using transcranial electrical current stimulation. Prog Brain Res. 2021;264:151-70.

https://doi.org/10.1016/bs.pbr.2021.01.011

PMid:34167654

Du JC, Chiu TF, Lee KM, Wu HL, Yang YC, Hsu SY, et al. Tourette Syndrome in Children: An Updated Review. Pediatr Neonatol. 2010 Oct;51(5):255-64.

https://doi.org/10.1016/S1875-9572(10)60050-2

PMid:20951354

Dyke K, Jackson GM, Nixon E, Jackson SR. Effects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette's syndrome. Exp Brain Res. 2019 Nov 1;237(11):2853-63.

https://doi.org/10.1007/s00221-019-05637-5

PMid:31463531 PMCid:PMC6794240

Wang Z, Maia TV, Marsh R, Colibazzi T, Gerber A, Peterson BS. The Neural Circuits That Generate Tics in Tourette's Syndrome. Am J Psychiatry. 2011 Dec;168(12):1326-37.

https://doi.org/10.1176/appi.ajp.2011.09111692

PMid:21955933 PMCid:PMC4246702

Grados M, Huselid R, Duque-Serrano L. Transcranial Magnetic Stimulation in Tourette Syndrome: A Historical Perspective, Its Current Use and the Influence of Comorbidities in Treatment Response. Brain Sci. 2018 Jul 6;8(7):129.

https://doi.org/10.3390/brainsci8070129

PMid:29986411 PMCid:PMC6071080

Rufener KS, Krauel K, Meyer M, Heinze HJ, Zaehle T. Transcranial electrical stimulation improves phoneme processing in developmental dyslexia. Brain Stimulat. 2019;12(4):930-7.

https://doi.org/10.1016/j.brs.2019.02.007

PMid:30826318

Niknasab F, Bagherzadeh F, Sheikh M, Moghadamzadeh A, Hominian D. Effectiveness of Transcranial Direct Current Stimulation (tDCS) on Visual-Motor Integration in Children with Developmental Coordination Disorder (DCD). Neuropsychology [Internet]: 2023 Jul 23 [cited 2024 Nov 29]; Available from: https://clpsy.journals.pnu.ac.ir/article_10576_en.html.

Feyzi Dehkharghani S, Chiappedi MA, Hajloo N, Basharpoor S. The effectiveness of transcranial direct current stimulation (tDCS) on information processing speed in children with intellectual disability. Res Dev Disabil. 2024 Dec;155:104863.

https://doi.org/10.1016/j.ridd.2024.104863

PMid:39486385

Tunmer W, Greaney K. Defining Dyslexia. J Learn Disabil. 2010 May;43(3):229-43.

https://doi.org/10.1177/0022219409345009

PMid:19834134

Castro IC de, Muszkat M, Lima VC, Rizzutti S, Ávila CB de, Castro IC de, et al. Treating developmental dyslexia using transcranial stimulation combined with a reading stimulation program: A pilot study. World J Biol Pharm Health Sci. 2021;7(3):080-8.

https://doi.org/10.30574/wjbphs.2021.7.3.0105

Marchesotti S, Nicolle J, Merlet I, Arnal LH, Donoghue JP, Giraud AL. Selective enhancement of low-gamma activity by tACS improves phonemic processing and reading accuracy in dyslexia. PLOS Biol. 2020 Sep 8;18(9):e3000833.

https://doi.org/10.1371/journal.pbio.3000833

PMid:32898188 PMCid:PMC7478834

Harris SR, Mickelson ECR, Zwicker JG. Diagnosis and management of developmental coordination disorder. CMAJ. 2015 Jun 16;187(9):659-65.

https://doi.org/10.1503/cmaj.140994

PMid:26009588 PMCid:PMC4467929

Jazini F. Comparison of the Effect of Direct Transcranial Electrical Stimulation of Motor and Vision Cortex on Working Memory and Motor Performance in Children with Developmental Coordination Disorder. Neurosci J Shefaye Khatam. 2022 Jul 1;10(3):1-12.

https://doi.org/10.52547/shefa.10.3.1

Grohs MN, Craig BT, Kirton A, Dewey D. Effects of Transcranial Direct Current Stimulation on Motor Function in Children 8-12 Years With Developmental Coordination Disorder: A Randomized Controlled Trial. Front Hum Neurosci. 2020;14:608131.

https://doi.org/10.3389/fnhum.2020.608131

PMid:33362497 PMCid:PMC7759610

Akremi H, Hamel R, Dumas A, Camden C, Corriveau H, Lepage JF. Cerebellar Transcranial Direct Current Stimulation in Children with Developmental Coordination Disorder: A Randomized, Double-Blind, Sham-Controlled Pilot Study. J Autism Dev Disord. 2022 Jul;52(7):3202-13.

https://doi.org/10.1007/s10803-021-05202-6

PMid:34318430 PMCid:PMC9213272

Purugganan O. Intellectual Disabilities. Pediatr Rev. 2018 Jun 1;39(6):299-309.

https://doi.org/10.1542/pir.2016-0116

PMid:29858292

Fathi Azar E, Hejazi-Shirmard M, Mirzaie H. Cognitive enhancement through technology: A review of transcranial electrical stimulation (TES) interventions in children and adolescents with specific learning disabilities. Child Care Health Dev. 2024 Sep;50(5):e13318.

https://doi.org/10.1111/cch.13318

PMid:39118316

Maralan HS, Vahedi S, Chalabianloo G. Meta-Analysis of the Effectiveness of Transcranial Direct Current Stimulation on the Memory of People with Learning Disabilities. J Adolesc Youth Psychol Stud JAYPS. 2023 Mar 1;4(3):67-82.

https://doi.org/10.61838/kman.jayps.4.3.7

Smith JR, DiSalvo M, Green A, Ceranoglu TA, Anteraper SA, Croarkin P, et al. Treatment Response of Transcranial Magnetic Stimulation in Intellectually Capable Youth and Young Adults with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Neuropsychol Rev. 2023 Dec 1;33(4):834-55.

https://doi.org/10.1007/s11065-022-09564-1

PMid:36161554 PMCid:PMC10039963

Kaokhieo J, Tretriluxana J, Chaiyawat P, Siripornpanich V, Permpoonputtana K, Tretriluxana S, et al. Effects of repetitive transcranial magnetic stimulation combined with action-observation-execution on social interaction and communication in autism spectrum disorder: Feasibility study. Brain Res. 2023 Apr 1;1804:148258.

https://doi.org/10.1016/j.brainres.2023.148258

PMid:36702183

Yang Y, Jiang L, He R, Song P, Xu P, Wang Y, et al. Repetitive transcranial magnetic stimulation modulates long-range functional connectivity in autism spectrum disorder. J Psychiatr Res. 2023 Apr;160:187-94.

https://doi.org/10.1016/j.jpsychires.2023.02.021

PMid:36841084

Oberman LM, Enticott PG, Casanova MF, Rotenberg A, Pascual-Leone A, McCracken JT, et al. Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research. Autism Res. 2016 Feb;9(2):184-203.

https://doi.org/10.1002/aur.1567

PMid:26536383 PMCid:PMC4956084

Bruckmann S, Hauk D, Roessner V, Resch F, Freitag CM, Kammer T, et al. Cortical inhibition in attention deficit hyperactivity disorder: new insights from the electroencephalographic response to transcranial magnetic stimulation. Brain. 2012 Jul 1;135(7):2215-30.

https://doi.org/10.1093/brain/aws071

PMid:22492560

Millichap JG. Reduced Cortical Inhibition and EEG Response to Transcranial Magnetic Stimulation in ADHD. Pediatr Neurol Briefs. 2012 Aug 1;26(8):59.

https://doi.org/10.15844/pedneurbriefs-26-8-3

Sheen JZ. Treatment Response Biomarkers of Accelerated Low. Frequency Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder [Internet] [PhD Thesis]: University of Toronto (Canada); 2023 [cited 2024 Nov 27].

Steuber ER, McGuire JF. A meta-analysis of transcranial magnetic stimulation in Tourette syndrome. J Psychiatr Res. 2024 May;173:34-40.

https://doi.org/10.1016/j.jpsychires.2024.02.057

PMid:38479346 PMCid:PMC11018498

Kahl CK, Kirton A, Pringsheim T, Croarkin PE, Zewdie E, Swansburg R, et al. Bilateral transcranial magnetic stimulation of the supplementary motor area in children with Tourette syndrome. Dev Med Child Neurol. 2021;63(7):808-15.

https://doi.org/10.1111/dmcn.14828

PMid:33634500

De Almeida LR, Hansen PC. Neural correlates of the effects of tDCS stimulation over the LIFG for phonological processing in dyslexia [Internet]. 2019 [cited 2024 Nov 30]. Available from: http://biorxiv.org/lookup/doi/10.1101/522847

https://doi.org/10.1101/522847

Yue Q, Martin RC. Phonological Working Memory Representations in the Left Inferior Parietal Lobe in the Face of Distraction and Neural Stimulation. Front Hum Neurosci. 2022;16:890483.

https://doi.org/10.3389/fnhum.2022.890483

PMid:35814962 PMCid:PMC9259857

Pezoa-Peña I, Julio-Ramos T, Cigarroa I, Martella D, Solomons D, Toloza-Ramirez D. Neuropsychological and Anatomical-Functional Effects of Transcranial Magnetic Stimulation in Post-Stroke Patients with Cognitive Impairment and Aphasia: A Systematic Review. Neuropsychol Rev. 2024 Jun 13; 4: 1-5.

https://doi.org/10.1007/s11065-024-09644-4

PMid:38867020

Vaishnavi S. Transcranial Magnetic Stimulation for Developmental Neuropsychiatric Disorders with Inflammation. Dev Neurosci. 2023;45(6):342-8.

https://doi.org/10.1159/000535103

PMid:37944502 PMCid:PMC10664335

Gupta M, Rajak BL, Bhatia D, Mukherjee A. Transcranial Magnetic Stimulation Therapy in Spastic Cerebral Palsy Children Improves Motor Activity. J Neuroinfectious Dis [Internet]: 2016 [cited 2024 Nov 30]; Available from: https://www.omicsonline.com/open-access/transcranial-magnetic-stimulation-therapy-in-spastic-cerebral-palsy-children-improves-motor-activity-2314-7326-1000231.php?aid=82320

https://doi.org/10.4172/2314-7326.1000231

Klomjai W, Katz R, Lackmy-Vallée A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS). Ann Phys Rehabil Med. 2015 Sep;58(4):208-13.

https://doi.org/10.1016/j.rehab.2015.05.005

PMid:26319963

Hallett M. Transcranial magnetic stimulation and the human brain. Nature. 2000 Jul;406(6792):147-50.

https://doi.org/10.1038/35018000

PMid:10910346

Kobayashi M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Lancet Neurol. 2003 Mar;2(3):145-56.

https://doi.org/10.1016/S1474-4422(03)00321-1

PMid:12849236

Schmidgen J, Konrad K, Roessner V, Bender S. The external evocation and movement-related modulation of motor cortex inhibition in children and adolescents with Tourette syndrome - a TMS/EEG study. Front Neurosci [Internet]: 2023 Oct 19 [cited 2024 Dec 1]; Available from: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1209801/full

https://doi.org/10.3389/fnins.2023.1209801

PMid:37928740 PMCid:PMC10620315

Krishnan C, Santos L, Peterson MD, Ehinger M. Safety of Noninvasive Brain Stimulation in Children and Adolescents. Brain Stimul Basic Transl Clin Res Neuromodulation. 2015 Jan 1;8(1):76-87.

https://doi.org/10.1016/j.brs.2014.10.012

PMid:25499471 PMCid:PMC4459719

Biermann L. Cortical excitability in adolescents with depression-An investigation of the TMS-evoked potential N100 as a possible biomarker. [Internet] [PhD Thesis]: Universität zu Köln; 2024 [cited 2024 Nov 27]; Available from: https://kups.ub.uni-koeln.de/73396/

Gill JL, Schneiders JA, Stangl M, Aghajan ZM, Vallejo M, Hiller S, et al. A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder. Nat Commun. 2023 May 24;14(1):2997.

https://doi.org/10.1038/s41467-023-38712-1

PMid:37225710 PMCid:PMC10209131

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2025-08-05

How to Cite

Salemi, M. H. (2025). Transcranial Brain Stimulation for Neurodevelopmental Disorders: Neuromodulation and Neurodevelopmental Disorders. Galen Medical Journal, e3782. https://doi.org/10.31661/gmj.vi.3782

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