Relationship between Diabetes with Drug Use, Family History and Alcohol; Insights from the PERSIAN Cohort Study for Health Service Management

Authors

  • Mohammad Khammarnia Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  • Alireza Ansari-Moghaddam Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  • Zahra Takamoli Poshtehee Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  • Fariba Shahraki-Sanavi Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  • Mahdi Mohammadi Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran https://orcid.org/0000-0001-9616-6125

DOI:

https://doi.org/10.31661/gmj.v14i.3853

Keywords:

Diabetes; Family History; Alcohol; Drug

Abstract

Background: In recent decades, the prevalence of diabetes, alcohol and tobacco consumption has increased in Iran and the world. This study aimed to investigate the relationship between diabetes with family history, alcohol and tobacco consumption in Iran. Materials and Methods: A cross-sectional study was carried out in the southeast of Iran in 2023_2024. The target population consisted of 10,016 individuals aged between 35 and 70 years. The data required for this study was obtained from the data collected by ZACS (Zahedan Adult Cohort Study) in the southeast of Iran. The data on general information, diabetes, family history of diabetes and alcohol consumption were collected through a standard questionnaire and were analyzed using descriptive statistics and independent t-tests, chi-square and logistic regression in SPSS 22 software. Results: The prevalence of diabetes was 19.0% and it was more prevalent in women (20.1%), unemployed people (21.9%) and age groups of 60 years and older (P<0.05). The prevalence of diabetes was 37.8% in first relatives and 19.4% in second relatives. Although only 2.4% of people consumed alcohol, diabetes was less common in people who consumed alcohol than in others (P<0.001). In univariate results, drug use reduced the chance of developing diabetes (OR=0.86, P=0.026). However, there was not significant relationship between drug use and diabetes after adjusting for history of diabetes in relatives (OR=0.99, P=0.229). Family history had a positive effect on developing diabetes (P<0.001). Conclusion: The findings showed the family history had a positive effect on developing diabetes. These results show the necessity of examining the family history of people, identifying people at risk, and also providing the necessary education for the prevention of diabetes. It is recommended that people with a family history of diabetes take diabetes preventive measures and modify their lifestyle.

References

Demir S, Nawroth PP, Herzig S, Ekim Üstünel B. Emerging targets in type 2 diabetes and diabetic complications. Advanced Science. 2021;8(18):2100275.

https://doi.org/10.1002/advs.202100275

PMid:34319011 PMCid:PMC8456215

Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nature reviews nephrology. 2020;16(7):37790.

https://doi.org/10.1038/s41581-020-0278-5

PMid:32398868 PMCid:PMC9639302

AnsariMoghaddam A, Setoodehzadeh F, Khammarnia M, Adineh HA. Economic cost of diabetes in the Eastern Mediterranean region countries: A metaanalysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(5):11018.

https://doi.org/10.1016/j.dsx.2020.06.044

PMid:32653635

Egan AM, Dinneen SF. What is diabetes? Medicine. 2019;47(1):14.

https://doi.org/10.1016/j.mpmed.2018.10.002

Khammarnia M, Setoodehzadeh F, Barfar E, Rezaei K, Peyvand M. Evaluation of direct medical costs. in hospitalized diabetic patients after health reform: plan; 2021.

Padhi S, Nayak AK, Behera A. Type II diabetes mellitus: a review on recent drug based therapeutics. Biomedicine & Pharmacotherapy. 2020;131:110708.

https://doi.org/10.1016/j.biopha.2020.110708

PMid:32927252

Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine. 2010;38(11):6026.

https://doi.org/10.1016/j.mpmed.2010.08.007

Arneth B, Arneth R, Shams M. Metabolomics of type 1 and type 2 diabetes. International journal of molecular sciences. 2019;20(10):2467.

https://doi.org/10.3390/ijms20102467

PMid:31109071 PMCid:PMC6566263

Dennedy MC, Dinneen SF. Management of type 1 diabetes mellitus. Medicine. 2010;38(11):6107.

https://doi.org/10.1016/j.mpmed.2010.08.002

Strain WD, Paldánius P. Diabetes, cardiovascular disease and the microcirculation. Cardiovascular diabetology. 2018;17:110.

https://doi.org/10.1186/s12933-018-0703-2

PMid:29669543 PMCid:PMC5905152

Boles A, Kandimalla R, Reddy PH. Dynamics of diabetes and obesity: Epidemiological perspective. Biochimica et Biophysica Acta (BBA)Molecular Basis of Disease. 2017;1863(5):102636.

https://doi.org/10.1016/j.bbadis.2017.01.016

PMid:28130199 PMCid:PMC5429876

Abi Khalil C, Al Suwaidi J, Refaat M, Mohammedi K. Cardiac complications of diabetes. Hindawi. 2018; 2018:1-12.

https://doi.org/10.1155/2018/8578394

PMid:29850580 PMCid:PMC5903188

Preiss D, Sattar N. Reducing cardiovascular risk in type 2 diabetes mellitus. Medicine. 2015;43(1):712.

https://doi.org/10.1016/j.mpmed.2014.10.011

Ilhan MN, Yapar D. Alcohol consumption and alcohol policy. Turkish journal of medical sciences. 2020;50(5):1197202.

https://doi.org/10.3906/sag-2002-237

PMid:32421277 PMCid:PMC7491269

Mishra VK, Srivastava S, Muhammad T, Murthy P. Relationship between tobacco use, alcohol consumption and noncommunicable diseases among women in India: evidence from National Family Health Survey201516. BMC public health. 2022;22(1):713.

https://doi.org/10.1186/s12889-022-13191-z

PMid:35410193 PMCid:PMC8996590

Eghtesad S, Hekmatdoost A, Faramarzi E, Homayounfar R, Sharafkhah M, Hakimi H, et al. Validity and reproducibility of a food frequency questionnaire assessing food group intake in the PERSIAN Cohort Study. Frontiers in Nutrition. 2023;10:1059870.

https://doi.org/10.3389/fnut.2023.1059870

PMid:37599697 PMCid:PMC10436288

Khammarnia M, Zanganeh Baygi M, Mooziri M, Okati M, Boolaghi M, Okati M, et al. Assessment of Productivity in Health Centers after Health Transformation Plan in Iran. Journal of Health Sciences & Surveillance System. 2021;9(3):17983.

Zare MG, OkatiAliabad H, AnsariMoghaddam A, Mohammadi M, ShahrakiSanavi F. Prevalence and risk factors of prehypertension and hypertension among adults in Southeastern Iran: Findings from the baseline survey of the Zahedan adult cohort study. Plos one. 2023;18(12):e0295270.

https://doi.org/10.1371/journal.pone.0295270

PMid:38060532 PMCid:PMC10703255

He Z, Yamana H, Yasunaga H, Li H, Wang X. Analysis of risk factors and clinical implications for diabetes in firstdegree relatives in the northeastern region of China. Frontiers in Endocrinology. 2024;15:1385583.

https://doi.org/10.3389/fendo.2024.1385583

PMid:38919473 PMCid:PMC11197463

Han X, Wei Y, Hu H, Wang J, Li Z, Wang F, et al. Genetic risk, a healthy lifestyle, and type 2 diabetes: the DongfengTongji cohort study. The Journal of Clinical Endocrinology & Metabolism. 2020;105(4):124250.

https://doi.org/10.1210/clinem/dgz325

PMid:31900493

Xiong Xf, Wei L, Xiao Y, Han YC, Yang J, Zhao H, et al. Family history of diabetes is associated with diabetic foot complications in type 2 diabetes. Scientific reports. 2020;10(1):17056.

https://doi.org/10.1038/s41598-020-74071-3

PMid:33051498 PMCid:PMC7555504

Nalini M, Khoshnia M, Kamangar F, Sharafkhah M, Poustchi H, Pourshams A, et al. Joint effect of diabetes and opiate use on allcause and causespecific mortality: the Golestan cohort study. International journal of epidemiology. 2021;50(1):31424.

https://doi.org/10.1093/ije/dyaa126

PMid:32810213 PMCid:PMC7938504

mohammad Bakhshani N. Prevalence of smoking and drug abuse in students of Zahedan high schools. Zahedan Journal of Research in Medical Sciences. 2004;6(1): 1?.

Khammarnia M, AnsariMoghaddam A, Peyvand M, Setoodehzadeh F. Role of substance abuse treatment centers in addiction recurrence. International Journal of High Risk Behaviors and Addiction. 2019;8(4): e92746.

https://doi.org/10.5812/ijhrba.91864

Winhusen T, Theobald J, Kaelber DC, Lewis D. Medical complications associated with substance use disorders in patients with type 2 diabetes and hypertension: electronic health record findings. Addiction. 2019;114(8):146270.

https://doi.org/10.1111/add.14607

PMid:30851217 PMCid:PMC6626564

Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature reviews endocrinology. 2018;14(2):8898.

https://doi.org/10.1038/nrendo.2017.151

PMid:29219149

Mongkolsucharitkul P, Surawit A, Manosan T, Ophakas S, Suta S, Pinsawas B, et al. Metabolic and genetic risk factors associated with prediabetes and type 2 diabetes in Thai healthcare employees: A longterm study from the Siriraj Health (SIH) cohort study. PloS one. 2024;19(6):e0303085.

https://doi.org/10.1371/journal.pone.0303085

PMid:38941315 PMCid:PMC11213315

Ciarambino T, Crispino P, Leto G, Mastrolorenzo E, Para O, Giordano M. Influence of gender in diabetes mellitus and its complication. International journal of molecular sciences. 2022;23(16):8850.

https://doi.org/10.3390/ijms23168850

PMid:36012115 PMCid:PMC9408508

Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal JF, Montagner A, et al. Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia. 2020;63:45361.

https://doi.org/10.1007/s00125-019-05040-3

PMid:31754750 PMCid:PMC6997275

Campagna D, Alamo A, Di Pino A, Russo C, Calogero A, Purrello F, et al. Smoking and diabetes: dangerous liaisons and confusing relationships. Diabetology & metabolic syndrome. 2019;11:112.

https://doi.org/10.1186/s13098-019-0482-2

PMid:31666811 PMCid:PMC6813988

Berlin I, Durlach V, Thomas D, Vergès B, Le Faou AL. Tobacco smoking and diabetes A comparative survey among diabetologists and smoking cessation specialists. Primary Care Diabetes. 2024;18(2):2415.

https://doi.org/10.1016/j.pcd.2024.01.009

PMid:38296760

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Published

2025-12-27

How to Cite

Khammarnia, M., Ansari-Moghaddam, A., Takamoli Poshtehee, Z., Shahraki-Sanavi, F., & Mohammadi, M. (2025). Relationship between Diabetes with Drug Use, Family History and Alcohol; Insights from the PERSIAN Cohort Study for Health Service Management. Galen Medical Journal, 14, e3853. https://doi.org/10.31661/gmj.v14i.3853

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Original Article