Herbal Medicines Used in Treatment of Nonalcoholic Fatty Liver Disease: A Mini-Review
DOI:
https://doi.org/10.31661/gmj.v5i3.654Keywords:
Nonalcoholic Fatty Liver Disease, Clinical Trial, Herbal MedicineAbstract
Botanicals are used traditionally for treatment and prevention of the liver diseases. In the past decades, the use of herbal remedies for non-alcoholic fatty liver disease (NAFLD) has become more popular. This study was conducted to determine the efficacy of herbal medicines used for the treatment of NAFLD in clinical trials. This research was carried out by searching through the studies done on human beings, which have been reported from 1966 to Feb. 2016 and recorded in Cochrane library, Google Scholar, Pub Med, and Scopus. A number of medicinal herbs have been evaluated in human trials. A scientific evaluation of these manuscripts can give an insight into the ideas of the past: it might well be valuable in finding new data on clinical use of the herbal medicines for the treatment of NAFLD and should lead to future opportunities to investigate their potential medicinal use.
References
Masoodi M, Rezadoost A, Panahian M, Vojdanian M. Effects of Silymarin on Reducing Liver Aminotransferases in Patients with Nonalcoholic Fatty Liver Diseases. Govaresh. 2013;18(3):181-5.
Iloon Kashkooli R, Najafi SS, Sharif F, Hamedi A, Hoseini Asl MK, Najafi Kalyani M, et al. The effect of berberis vulgaris extract on transaminase activities in non-alcoholic Fatty liver disease. Hepat Mon. 2015;15(2):e25067.
Alavian SM, Mohammad-Alizadeh AH, Esna-Ashari F, Ardalan G, Hajarizadeh B. Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measures. Liver Int. 2009;29(2):159-63.
Lankarani KB, Ghaffarpasand F, Mahmoodi M, Lotfi M, Zamiri N, Heydari ST, et al. Non Alcoholic Fatty Liver Disease in Southern Iran: A Population Based Study. Hepat Mon. 2013;13(5):e9248.
Gu C-l, Zhang Y-k, Fu Y-x, Yang S-f, Li X-q. Effect of Tiaozhi Yanggan Decoction (调脂养è‚汤) in treating patients with non-alcoholic fatty liver. Chin J Integr Med. 2007;13:275-9.
Assy N, Nassar F, Nasser G, Grosovski M. Olive oil consumption and non-alcoholic fatty liver disease. World J Gastroenterol. 2009;15(15):1809-15.
Tsuruta Y, Nagao K, Kai S, Tsuge K, Yoshimura T, Koganemaru K et al. Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. Lipids Health Dis. 2011;10(1):1.
Zelber-Sagi S, Ratziu V, Oren R. Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence. World J Gastroenterol. 2011;17(29):3377-89.
Li L, Zhang X-j, Lan Y, Xu L, Zhang X-z, Wang H-h. Treatment of non-alcoholic fatty liver disease by Qianggan Capsule (强è‚胶囊). Chin J Integr Med. 2010;16:23-7.
Luper S. A review of plants used in the treatment of liver disease: part 1. Altern Med Rev. 1998;3(6):410-21.
Hashempur MH, Lari ZN, Ghoreishi PS, Daneshfard B, Ghasemi MS, Homayouni K, et al. A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome. Complement Ther Clin Pract. 2015;21(4):223-8.
Pasalar M, Lankarani KB. Herbal medicines, a prominent component in complementary and alternative medicine use in gastrointestinal field. Am J Gastroenterol. 2015;110(6):935-.
Shi K-Q, Fan Y-C, Liu W-Y, Li L-F, Chen Y-P, Zheng M-H. Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis. Mol Biol Rep. 2012;39(10):9715-22.
Toosi MN, Ardekani MRS, Minaie MB, Nazim I, Esfahani MM, Khadem E. Fatty liver disease from the perspective of traditional Iranian medicine. Quran and Medicine. 2012;1(4):117-8.
M Zarshenas M, Ranjbar Farrokhi R, Akhavein M, Reza Kiafar M. A panoramic view of chronic liver diseases and natural remedies reported in Traditional Persian Medicine. Curr Pharm Des. 2016;22(3):350-64.
Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A systematic review of anti-obesity medicinal plants-an update. J Diabetes metab disord. 2013;12(1):1.
Xiao J, So KF, Liong EC, Tipoe GL. Recent advances in the herbal treatment of non-alcoholic Fatty liver disease. J Tradit Complement Med. 2013;3(2):88-94.
Liu ZL, Xie LZ, Zhu J, Li GQ, Grant SJ, Liu JP. Herbal medicines for fatty liver diseases. Cochrane Database Syst Rev. 2013;8.
Ebrahimi-Mameghani M, Aliashrafi S, Javadzadeh Y, AsghariJafarabadi M. The Effect of Chlorella vulgaris Supplementation on Liver En-zymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease. Health Promot Perspect. 2014;4(1):107-15.
Panahi Y, Ghamarchehreh ME, Beiraghdar F, Zare R, Jalalian HR, Sahebkar A. Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. Hepatogastroenterology. 2012;59(119):2099-103.
Sakata R, Nakamura T, Torimura T, Ueno T, Sata M. Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study. Int J Mol Med. 2013;32(5):989-94.
Hajiaghamohammadi AA, Ziaee A, Samimi R. The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Phytother Res. 2012;26(9):1381-4.
Wong VW, Wong GL, Chan AW, Chu WC, Choi PC, Chim AM, et al. Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria: a randomized trial. J Gastroenterol Hepatol. 2013;28(1):57-62.
Hashemi SJ, Hajiani E, Sardabi EH. A placebo-controlled trial of silymarin in patients with nonalcoholic fatty liver disease. Hepat Mon. 2009;9(4):265-70.
Shavakhi A, Torki M, Khodadoostan M, Shavakhi S. Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial. Adv Biomed Res. 2015;4.
Kashkooli RI, Najafi SS, Sharif F, Hamedi A, Asl MKH, Kalyani MN, et al. The Effect of Berberis Vulgaris Extract on Transaminase Activities in Non-Alcoholic Fatty Liver Disease. Hepat Mon. 2015;15(2).
Askari F, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutr Res. 2014;34(2):143-8.
Caporaso N, Morisco F, Camera S, Graziani G, Donnarumma L, Ritieni A. Dietary approach in the prevention and treatment of NAFLD. Front Biosci (Landmark Ed). 2011;17:2259-68.
Centis E, Marzocchi R, Suppini A, Dalle Grave R, Villanova N, J Hickman I et al. The role of lifestyle change in the prevention and treatment of NAFLD. Curr Pharm Des. 2013;19(29):5270-9.
Hossain N, Kanwar P, Mohanty SR. A Comprehensive Updated Review of Pharmaceutical and Nonpharmaceutical Treatment for NAFLD. Gastroenterol Res Prac. 2016;2016.
Golshani AR, Daneshfard B, Mosleh G, Salehi AR. Drugs and Pharmacology in the Islamic Middle Era. Pharm Hist (Lond). 2015;45(3):64-9.
Sakata R, Ueno T, Nakamura T, Hashimoto O, Sakamoto M, Torimura T, et al. 713 Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease patients: Double-blind placebo-controlled study. J Hepatol. 2006;44:S262.
Mosaffa-Jahromi M, Pasalar M, Afsharypuor S, Choopani R, Mosaddegh M, Kamalinejad M, et al. Preventive Care for Gastrointestinal Disorders; Role of Herbal Medicines in Traditional Persian Medicine. Jundishapur J Nat Pharm Prod. 2015;10(4):e21029.
Pasalar M, Lankarani KB, Mehrabani D, Tolide-ie HR, Naseri M. The Effect of Descureania Sophia L. and Prunus Domestica L. in Prevention of Constipation among Iranian Hajj Pilgrims, Saudi Arabia. Res J Pharm Biol Chem Sci. 2013;4(2):1195-204.
Ebrahimi-Mameghani M, Aliashrafi S, Javadzadeh Y, AsghariJafarabadi M. The Effect of Chlorella vulgaris Supplementation on Liver Enzymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease. Health Promot Perspec. 2014;4(1):107.
Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementrmed (2006). 2008;15(1):9-20.
Ni X, Wang H. Silymarin attenuated hepatic steatosis through regulation of lipid metabolism and oxidative stress in a mouse model of nonalcoholic fatty liver disease (NAFLD). Am J Transl Res. 2016;8(2):1073.
Espinosa C, Lópezâ€Jiménez JA, Pérezâ€Llamas F, Guardiola FA, Esteban MA, Arnao MB, et al. Longâ€term intake of white tea prevents oxidative damage caused by adriamycin in kidney of rats. J Sci Food Agric. 2015.
Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring). 2007;15(6):1473-83.
Wang H, Wen Y, Du Y, Yan X, Guo H, Rycroft JA, et al. Effects of catechin enriched green tea on body composition. Obesity (Silver Spring). 2010;18(4):773-9.
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