Maternal Psychological Distress and Repeated Implantation Failure: A Mini Review
DOI:
https://doi.org/10.31661/gmj.v15i.4201Keywords:
Repeated Implantation Failure; Infertility; Stress; Psychological Factors; Fertility TreatmentAbstract
Infertile couples can try assisted reproductive technology (ART) interventions to become pregnant. Repeated implantation failure (RIF) is diagnosed when pregnancy is not achieved after three or more transfers of high-quality embryos. Despite the psychological research indicating that repeated ART failure is strongly associated with negative psychological consequences for both men and women, there are currently no studies addressing the potentially traumatic aspects of the experiences of RIF women. Thereby, we present a summary of the current research to emphasize the intersections between traumatic experiences and RIF, particularly the different features of RIF women in ART programs potentially more at risk for trauma. The aim of this study is to examine the role of psychological factors in RIF and to emphasize the need for further research to better understand these processes in ART treatments for women with RIF.
References
Braverman AM, Sofer K. Psychosocial Implications of Recurrent Implantation Failure. Recurrent Implantation Failure Etiologies and Clinical Management: Springer; 2017.
https://doi.org/10.1007/978-3-319-71967-2_12
Aimagambetova G, Issanov A, Terzic S, Bapayeva G, Ukybassova T, Baikoshkarova S et al. The effect of psychological distress on IVF outcomes: Reality or speculations? PLoS One. 2020;15(12):e0242024.
https://doi.org/10.1371/journal.pone.0242024
PMid:33315878 PMCid:PMC7735622
Berg BJ, Wilson JF. Psychological functioning across stages of treatment for infertility. Journal of behavioral Medicine. 1991;14(1):1126.
https://doi.org/10.1007/BF00844765
PMid:2038042
Brentjens LS, Habets D, Den Hartog J, AlNasiry S, Wieten L, Morré S et al. Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Miscarriage (MURIM Study). BMJ open. 2022;12(6):e056714.
https://doi.org/10.1136/bmjopen-2021-056714
PMid:35676021 PMCid:PMC9185487
AssayshÖberg S, Borneskog C, Ternström E. Women's experience of infertility & treatment-A silent grief and failed care and support. Sexual & reproductive healthcare. 2023;37:100879.
https://doi.org/10.1016/j.srhc.2023.100879
PMid:37356208
Sharma A, Shrivastava D, Sharma IVA. Psychological problems related to infertility. Cureus. 2022;14(10):e30863.
https://doi.org/10.7759/cureus.30320
American Psychological Association. APA Dictionary of Psychology. Washington (DC): American Psychological Association; 2026.
Goharitaban S, Abedelahi A, Hamdi K, Khazaei M, Esmaeilivand M, Niknafs B. Role of endometrial microRNAs in repeated implantation failure (minireview). Frontiers in Cell and Developmental Biology. 2022;10:936173.
https://doi.org/10.3389/fcell.2022.936173
PMid:36060804 PMCid:PMC9437697
Shufaro Y, Schenker JG. Implantation failure, etiology, diagnosis and treatment. International Journal of Infertility & Fetal Medicine. 2013;2:17.
Goharitaban S, Hamdi K, Khazaei M, Esmaeilivand M, Niknafs B. Study of LIF, NR3C1, BCL6, miR494, and miR30d in Endometrial Epithelial Cells of Repeated Implantation Failure and Healthy Women Treated with Calcitriol and Letrozole in a Fibrin Scaffold. ImmunoAnalysis. 2022;2(1):12.
https://doi.org/10.34172/ia.2022.12
Salehpour S, Zamaniyan M, Saharkhiz N, Hosieni S, Seif S, Malih N et al. Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT. International Journal of Reproductive BioMedicine. 2016;14(9):583.
https://doi.org/10.29252/ijrm.14.9.583
PMid:27738660 PMCid:PMC5054295
Guo YB, Tang B, Zhang L, Wu X, Huang ZH. Anxiety and depression in recurrent implantation failure after frozenthawed embryo transfer and efficacy of endometrial receptivity testing. World Journal of Psychiatry. 2025;15(9):109175.
https://doi.org/10.5498/wjp.v15.i9.109175
PMid:40933169 PMCid:PMC12417924
Timeva T, Shterev A, Kyurkchiev S. Recurrent implantation failure: the role of the endometrium. Journal of reproduction & infertility. 2014;15(4):173.
Esmaeilivand M, Abedelahi A, Hamdi K, Farzadi L, Goharitaban S, Fattahi A et al. Role of miRNAs in preimplantation embryo development and their potential as embryo selection biomarkers. Reproduction, Fertility and Development. 2022;34(8):58997.
https://doi.org/10.1071/RD21274
PMid:35440361
Margalioth E, BenChetrit A, Gal M, EldarGeva T. Investigation and treatment of repeated implantation failure following IVFET. Human reproduction. 2006;21(12):303643.
https://doi.org/10.1093/humrep/del305
PMid:16905766 PMCid:PMC12040057
Vakili S, Koohpeyma F, SamareNajaf M, Jahromi BN, Jafarinia M, Goharitaban S et al. Investigating the effects of rosmarinic acid on ovarian tissue, inflammatory markers, and sex hormones in polycystic ovary syndrome rats. Physiological Reports. 2025;13(7):e70304.
https://doi.org/10.14814/phy2.70304
PMid:40170546 PMCid:PMC11962217
Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T et al. Recurrent implantation failure: definition and management. Reproductive biomedicine online. 2014;28(1):1438.
https://doi.org/10.1016/j.rbmo.2013.08.011
PMid:24269084
Esmaeilivand M, Fattahi A, Abedelahi A, Hamdi K, Farzadi L, Goharitaban S et al. microRNAs in the blastocoel fluid as accessible indicators of chromosomal normality. Reproductive Biology. 2022;22(4):100695.
https://doi.org/10.1016/j.repbio.2022.100695
PMid:36081236
Cousineau TM, Domar AD. Psychological impact of infertility. Best practice & research Clinical obstetrics & gynaecology. 2007;21(2):293308.
https://doi.org/10.1016/j.bpobgyn.2006.12.003
PMid:17241818
Righetti P, Zampieri M, Ciampa R, Baffoni A, Benazzi F, Salemi M. Assisted Reproduction Techniques: New Children, New Families. JSM Invitro Fertil. 2016;1(1):1005.
Calvo V, Masaro C, Fusco C. Attachment and emotion regulation across the life cycle. GIORNALE ITALIANO DI PSICOLOGIA. 2021;48(3/2021):7616.
Swanson A, Braverman AM. Psychological components of infertility. Family Court Review. 2021;59(1):6782.
https://doi.org/10.1111/fcre.12552
Hjelmstedt A, Widström AM, Wramsby H, Matthiesen AS, Collins A. Personality factors and emotional responses to pregnancy among IVF couples in early pregnancy: a comparative study. Acta obstetricia et gynecologica Scandinavica. 2003;82(2):15261.
https://doi.org/10.1034/j.1600-0412.2003.00040.x
PMid:12648178
Heffner LJ. Advanced maternal age-how old is too old? New England journal of medicine. 2004;351(19):19279.
https://doi.org/10.1056/NEJMp048087
PMid:15525717
Lampic C, Svanberg AS, Karlström P, Tydén T. Fertility awareness, intentions concerning childbearing, and attitudes towards parenthood among female and male academics. Human reproduction. 2006;21(2):55864.
https://doi.org/10.1093/humrep/dei367
PMid:16293651
Baram D, Tourtelot E, Muechler E, Huang KE. Psychosocial adjustment following unsuccessful in vitro fertilization. Journal of Psychosomatic Obstetrics & Gynecology. 1988;9(3):18190.
https://doi.org/10.3109/01674828809016800
Wallach EE, Seibel MM, Taymor ML. Emotional aspects of infertility. Fertility and sterility. 1982;37(2):13745.
https://doi.org/10.1016/S0015-0282(16)46029-2
PMid:7037462
Khalid A, Dawood S. Social support, selfefficacy, cognitive coping and psychological distress in infertile women. Archives of Gynecology and Obstetrics. 2020;302(2):42330.
https://doi.org/10.1007/s00404-020-05614-2
PMid:32458132
Al Aisari AH. Depression, anxiety, stress, social support, and couple adjustment among primary infertile Omani women. Oman: Sultan Qaboos University; 2023.
Powell B. Myths of fertility: Demeter and the Great Goddess. Classical myth. 2001;3:21647.
Gonzalez LO. Infertility as a transformational process: a framework for psychotherapeutic support of infertile women. Issues in Mental Health Nursing. 2000;21(6):61933.
https://doi.org/10.1080/01612840050110317
PMid:11271137
Greil AL. A secret stigma: The analogy between infertility and chronic illness and disability. Advances in medical sociology. 1991;2(1):1738.
Slade P, O'Neill C, Simpson AJ, Lashen H. The relationship between perceived stigma, disclosure patterns, support and distress in new attendees at an infertility clinic. Human reproduction. 2007;22(8):230917.
https://doi.org/10.1093/humrep/dem115
PMid:17580298
Boivin J, Takefnan JE. Impact of the invitro fertilization process on emotional, physical and relational variables. Human Reproduction. 1996;11(4):9037.
https://doi.org/10.1093/oxfordjournals.humrep.a019276
PMid:8671350
Yong P, Martin C, Thong J. A comparison of psychological functioning in women at different stages of in vitro fertilization treatment using the mean affect adjective check list. Journal of assisted reproduction and genetics. 2000;17(10):5536.
https://doi.org/10.1023/A:1026429712794
PMid:11209535 PMCid:PMC3455452
Wirtberg I, Möller A, Hogström L, Tronstad SE, Lalos A. Life 20 years after unsuccessful infertility treatment. Human Reproduction. 2007;22(2):598604.
https://doi.org/10.1093/humrep/del401
PMid:17124258
Fusco C, Righetti PL, Pellicelli C, Masaro C, Longo S, Calvo V. Traumatic potential of Recurrent Implantation Failure in Assisted Reproductive Technology paths for couples experiencing infertility. Mediterranean Journal of Clinical Psychology. 2023;11(1): e202301.
Verhaak CM, Smeenk JM, Evers AW, Kremer JA, Kraaimaat FW, Braat DD. Women's emotional adjustment to IVF: a systematic review of 25 years of research. Human reproduction update. 2007;13(1):2736.
https://doi.org/10.1093/humupd/dml040
PMid:16940360
Greil AL. Infertile bodies: Medicalization, metaphor, and agency. Infertility around the globe: New thinking on childlessness, gender, and reproductive technologies. 2002:10118.
Cipolletta S, Faccio E. Time experience during the assisted reproductive journey: A phenomenological analysis of Italian couples' narratives. Journal of Reproductive and Infant Psychology. 2013;31(3):28598.
https://doi.org/10.1080/02646838.2013.813627
Fusco C, Masaro C, Calvo V. 'I feel like I was born for something that my body can't do': a qualitative study on women's bodies within medicalized infertility in Italy. Psychology & health. 2024;39(11):155574.
https://doi.org/10.1080/08870446.2023.2180148
PMid:36799345
Benyamini Y, Gozlan M, Kokia E. Women's and men's perceptions of infertility and their associations with psychological adjustment: a dyadic approach. British journal of health psychology. 2009;14(1):116.
https://doi.org/10.1348/135910708X279288
PMid:18230194
Clarke LH, Martin-Matthews A, Matthews R. The continuity and discontinuity of the embodied self in infertility. Canadian Review of Sociology/Revue canadienne de sociologie. 2006;43(1):95113.
https://doi.org/10.1111/j.1755-618X.2006.tb00856.x
Cwikel J, Gidron Y, Sheiner E. Psychological interactions with infertility among women. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2004;117(2):12631.
https://doi.org/10.1016/j.ejogrb.2004.05.004
PMid:15541845
Domar AD, Broome A, Zuttermeister PC, Seibel M, Friedman R. The prevalence and predictability of depression in infertile women. Fertility and sterility. 1992;58(6):115863.
https://doi.org/10.1016/S0015-0282(16)55562-9
Oddens BJ, den Tonkelaar I, Nieuwenhuyse H. Psychosocial experiences in women facing fertility problems-a comparative survey. Human reproduction. 1999;14(1):25561.
https://doi.org/10.1093/humrep/14.1.255
PMid:10374131
Kaczmarek M, Grochowska W, Musial M, Spychalska M, Spychalski J, Dylik A et al. Depression among women experiencing infertility: A narrative review. Medical Science Pulse. 2025;19(2): 8592.
https://doi.org/10.5604/01.3001.0055.1315
Lok IH, Lee DTS, Cheung LP, Chung WS, Lo WK, Haines CJ. Psychiatric morbidity amongst infertile Chinese women undergoing treatment with assisted reproductive technology and the impact of treatment failure. Gynecologic and obstetric investigation. 2002;53(4):1959.
https://doi.org/10.1159/000064560
PMid:12186982
Schmidt L. Infertile couples' assessment of infertility treatment. Acta Obstetricia et Gynecologica Scandinavica. 1998;77(6):649.
https://doi.org/10.1034/j.1600-0412.1998.770612.x
PMid:9688243
Schmidt L, Holstein B, Boivin J, Sångren H, Tjørnhøj-Thomsen T, Blaabjerg J et al. Patients' attitudes to medical and psychosocial aspects of care in fertility clinics: findings from the Copenhagen Multi-centre Psychosocial Infertility (COMPI) Research Programme. Human Reproduction. 2003;18(3):62837.
https://doi.org/10.1093/humrep/deg149
PMid:12615837
Rajkhowa M, McConnell A, Thomas G. Reasons for discontinuation of IVF treatment: a questionnaire study. Human reproduction. 2006;21(2):35863.
https://doi.org/10.1093/humrep/dei355
PMid:16269448
Scheiber MD, Doody KJ, Foster ED, Grover SA, Heiser PW. Ovarian stimulation with follitropin delta is safe and effective: Results from the RITA randomized, doubleblind, placebocontrolled trials. Fertility and Sterility. 2025;125(1):54‑63.
https://doi.org/10.1016/j.fertnstert.2025.07.032
PMid:40714031
van Haaps A, Schreurs A, Rosielle K, Mijatovic V, Kallewaard J, Dreyer K. No anxiety or pain reduction by Virtual Reality during oocyte retrieval in IVF/ICSI treatment: results of a randomized controlled trial. Human Reproduction. 2025:deaf193.
https://doi.org/10.1093/humrep/deaf193
PMid:41057042 PMCid:PMC12769444
Verhaak CM, Smeenk JM, Van Minnen A, Kremer JA, Kraaimaat FW. A longitudinal, prospective study on emotional adjustment before, during and after consecutive fertility treatment cycles. Human reproduction. 2005;20(8):225360.
https://doi.org/10.1093/humrep/dei015
PMid:15817584 PMCid:PMC9317298
Neto BR, Barreiro M, Tomé A, ValeFernandes E. Psychosocial aspects of infertility and the impact of assisted reproductive techniquesa comprehensive review. JBRA Assisted Reproduction. 2025;29(2):378.
Nichols WC, Pace‑Nichols MA. Childless married couples In Nichols WC, Pace‑Nichols MA, Becvar DS, Napier AY, editors. Handbook of family development and intervention: Wiley; 2000.
van Balen F, TrimbosKemper T, Verdurmen J. Perception of diagnosis and openness of patients about infertility. Patient Education and Counseling. 1996;28(3):24752.
https://doi.org/10.1016/0738-3991(95)00852-7
PMid:8852100
CooperHilbert B. Infertility & involuntary childlessness. Helping couples cope: WW Norton & Co; 1998.
Daniluk JC. Gender and infertility In Leiblum SR, editor Infertility Psychological issues and counseling strategies. New York (NY): John Wiley and Sons; 1997.
Wallach EE, Mahlstedt PP. The psychological component of infertility. Fertility and sterility. 1985;43(3):33546.
https://doi.org/10.1016/S0015-0282(16)48428-1
PMid:3979571
Starc A, Trampuš M, Pavan Jukić D, GrgasBile C, Jukić T, Polona Mivšek A. Neplodnost i seksualni poremećaji: sustavni pregled literature. Acta clinica Croatica. 2019;58(3.):50815.
Ghorbani S, Abedi P, Hekmat K, Ghanbari S, Dibavand N. Recurrent implantation failure and sexual function in infertile Iranian women: a comparative cross sectional study. Reproductive health. 2022;19(1):103.
https://doi.org/10.1186/s12978-022-01409-7
PMid:35477422 PMCid:PMC9044669
OmaniSamani R, Amini P, Navid B, Sepidarkish M, Maroufizadeh S, AlmasiHashiani A. Prevalence of sexual dysfunction among infertile women in Iran: a systematic review and metaanalysis. International journal of fertility & sterility. 2018;12(4):278.
Bakhtiari A, Basirat Z, NasiriAmiri F. Sexual dysfunction in women undergoing fertility treatment in Iran: prevalence and associated risk factors. Journal of reproduction & infertility. 2016;17(1):26.
Leiblum SR, Aviv A, Hamer R. Life after infertility treatment: a longterm investigation of marital and sexual function. Human reproduction (Oxford, England). 1998;13(12):356974.
https://doi.org/10.1093/humrep/13.12.3569
PMid:9886552
Haimovici F, Anderson JL, Bates GW, Racowsky C, Ginsburg ES, Simovici D et al. Stress, anxiety, and depression of both partners in infertile couples are associated with cytokine levels and adverse IVF outcome. American journal of reproductive immunology. 2018;79(4):e12832.
https://doi.org/10.1111/aji.12832
PMid:29528174
Okobi OE. A systemic review on the association between infertility and sexual dysfunction among women utilizing female sexual function index as a measuring tool. Cureus. 2021;13(6):e16006.
https://doi.org/10.7759/cureus.16006
Ni Y, Tong C, Huang L, Zhou W, Zhang A. The analysis of fertility quality of life and the influencing factors of patients with repeated implantation failure. Health and quality of life outcomes. 2021;19(1):32.
https://doi.org/10.1186/s12955-021-01666-3
PMid:33494768 PMCid:PMC7831164
Collura B, Hayward B, Modrzejewski KA, Mottla GL, Richter KS, Catherino AB. Identifying factors associated with discontinuation of infertility treatment prior to achieving pregnancy: results of a nationwide survey. Journal of Patient Experience. 2024;11:23743735241229380.
https://doi.org/10.1177/23743735241229380
PMid:38414755 PMCid:PMC10898306
Domar AD, Rooney K, Hacker MR, Sakkas D, Dodge LE. Burden of care is the primary reason why insured women terminate in vitro fertilization treatment. Fertility and sterility. 2018;109(6):11216.
https://doi.org/10.1016/j.fertnstert.2018.02.130
PMid:29935647 PMCid:PMC6080203
Verhaak CM, Smeenk JM, Evers AW, van Minnen A, Kremer JA, Kraaimaat FW. Predicting emotional response to unsuccessful fertility treatment: a prospective study. Journal of behavioral medicine. 2005;28(2):18190.
https://doi.org/10.1007/s10865-005-3667-0
PMid:15957573
Mazure CM, Greenfeld DA. Psychological studies of in vitro fertilization/embryo transfer participants. Journal of in vitro fertilization and embryo transfer. 1989;6(4):24256.
https://doi.org/10.1007/BF01132873
PMid:2693559
Chen TH, Chang SP, Tsai CF, Juang KD. Prevalence of depressive and anxiety disorders in an assisted reproductive technique clinic. Human reproduction. 2004;19(10):23138.
https://doi.org/10.1093/humrep/deh414
PMid:15242992 PMCid:PMC12055705
Williams KE, Marsh WK, Rasgon NL. Mood disorders and fertility in women: a critical review of the literature and implications for future research. Human Reproduction Update. 2007;13(6):60716.
https://doi.org/10.1093/humupd/dmm019
PMid:17895237
Downey J, Yingling S, McKinney M, Husami N, Jewelewicz R, Maidman J. Mood disorders, psychiatric symptoms, and distress in women presenting for infertility evaluation. Fertility and sterility. 1989;52(3):42532.
https://doi.org/10.1016/S0015-0282(16)60912-3
PMid:2776896
Fassino S, Piero A, Boggio S, Piccioni V, Garzaro L. Anxiety, depression and anger suppression in infertile couples: a controlled study. Human Reproduction. 2002;17(11):298694.
https://doi.org/10.1093/humrep/17.11.2986
PMid:12407062
Holley SR, Pasch LA, Bleil ME, Gregorich S, Katz PK, Adler NE. Prevalence and predictors of major depressive disorder for fertility treatment patients and their partners. Fertility and sterility. 2015;103(5):13329.
https://doi.org/10.1016/j.fertnstert.2015.02.018
PMid:25796319 PMCid:PMC4417384
Boivin J, Griffiths E, Venetis CA. Emotional distress in infertile women and failure of assisted reproductive technologies: metaanalysis of prospective psychosocial studies. BmJ. 2011;342:d223.
https://doi.org/10.1136/bmj.d223
PMid:21345903 PMCid:PMC3043530
KlonoffCohen H, Chu E, Natarajan L, Sieber W. A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer. Fertility and sterility. 2001;76(4):67587.
https://doi.org/10.1016/S0015-0282(01)02008-8
PMid:11591398
KlonoffCohen H, Natarajan L. The concerns during assisted reproductive technologies (CART) scale and pregnancy outcomes. Fertility and sterility. 2004;81(4):9828.
https://doi.org/10.1016/j.fertnstert.2003.08.050
PMid:15066452
AsSanie S, Clevenger LA, Geisser ME, Williams DA, Roth RS. History of abuse and its relationship to pain experience and depression in women with chronic pelvic pain. American journal of obstetrics and gynecology. 2014;210(4):317.
https://doi.org/10.1016/j.ajog.2013.12.048
PMid:24412745 PMCid:PMC4086742
Cichowski SB, Dunivan GC, Komesu YM, Rogers RG. Sexual abuse history and pelvic floor disorders in women. Southern medical journal. 2013;106(12):675.
https://doi.org/10.1097/SMJ.0000000000000029
PMid:24305526 PMCid:PMC3902107
Shreffler KM, Tiemeyer S, Dorius C, Spierling T, Greil AL, McQuillan J. Infertility and fertility intentions, desires, and outcomes among US women. Demographic Research. 2016;35:114968.
https://doi.org/10.4054/DemRes.2016.35.39
PMid:42239943 PMCid:PMC13229554
Dehkordi SM, Khoshakhlagh AH, Yazdanirad S, MohammadianHafshejani A, RajabiVardanjani H. The effect of job stress on fertility, its intention, and infertility treatment among the workers: a systematic review. BMC public health. 2025;25(1):542.
https://doi.org/10.1186/s12889-025-21790-9
PMid:39930394 PMCid:PMC11812192
Homan GF, Davies M, Norman R. The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Human reproduction update. 2007;13(3):20923.
https://doi.org/10.1093/humupd/dml056
PMid:17208948
Vartiainen H, Saarikoski S, Halonen P, Rimon R. Psychosocial factors, female fertility and pregnancy: a prospective study-Part I: Fertility. Journal of Psychosomatic Obstetrics & Gynecology. 1994;15(2):6775.
https://doi.org/10.3109/01674829409025631
PMid:7921008
Facchinetti F, Volpe A, Matteo ML, Genazzani AR, Artini GP. An increased vulnerability to stress is associated with a poor outcome of in vitro fertilizationembryo transfer treatment. Fertility and sterility. 1997;67(2):30914.
https://doi.org/10.1016/S0015-0282(97)81916-4
PMid:9022608
Wdowiak A, Raczkiewicz D, Janczyk P, Bojar I, MakaraStudzińska M, WdowiakFilip A. Interactions of cortisol and prolactin with other selected menstrual cycle hormones affecting the chances of conception in infertile women. International Journal of Environmental Research and Public Health. 2020;17(20):7537.
https://doi.org/10.3390/ijerph17207537
PMid:33081268 PMCid:PMC7588978
Zehravi M, Maqbool M, Ara I. Polycystic ovary syndrome and infertility: an update. International journal of adolescent medicine and health. 2022;34(2):19.
https://doi.org/10.1515/ijamh-2021-0073
PMid:34293835
Karunyam BV, Abdul Karim AK, Naina Mohamed I, Ugusman A, Mohamed WM, Faizal AM et al. Infertility and cortisol: a systematic review. Frontiers in endocrinology. 2023;14:1147306.
https://doi.org/10.3389/fendo.2023.1147306
PMid:37455908 PMCid:PMC10344356
Rohleder N, Schommer NC, Hellhammer DH, Engel R, Kirschbaum C. Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress. Biopsychosocial Science and Medicine. 2001;63(6):96672.
https://doi.org/10.1097/00006842-200111000-00016
PMid:11719636
Atalyan AV, Shelokhov LF, Kolesnikova LI. Endocrine markers of fertility potential in reproductive age women with idiopathic hyperprolactinemia. J Pharm Res Int. 2020;32(23):717.
https://doi.org/10.9734/jpri/2020/v32i2330790
Alam F, Khan TA, Ali R, Tariq F, Rehman R. SIRTI and cortisol in unexplained infertile females; a cross sectional study, in Karachi Pakistan. Taiwanese Journal of Obstetrics and Gynecology. 2020;59(2):18994.
https://doi.org/10.1016/j.tjog.2020.01.004
PMid:32127136
Wdowiak A, MakaraStudzińska M, Raczkiewicz D, Cyranka K. Reproductive problems and intensity of anxiety and depression in women treated for infertility. Psychiatr Pol. 2022;56(1):15370.
https://doi.org/10.12740/PP/125885
PMid:35569155
GarcíaLeón MÁ, CaparrosGonzalez RA, RomeroGonzalez B, GonzalezPerez R, PeraltaRamirez I. Resilience as a protective factor in pregnancy and puerperium: Its relationship with the psychological state, and with Hair Cortisol Concentrations. Midwifery. 2019;75:13845.
https://doi.org/10.1016/j.midw.2019.05.006
PMid:31102974
Morrison AE, Fleming S, Levy MJ. A review of the pathophysiology of functional hypothalamic amenorrhoea in women subject to psychological stress, disordered eating, excessive exercise or a combination of these factors. Clinical endocrinology. 2021;95(2):22938.
https://doi.org/10.1111/cen.14399
PMid:33345352
Liu N, Yang H, Han L, Ma M. Oxytocin in women's health and disease. Frontiers in endocrinology. 2022;13:786271.
https://doi.org/10.3389/fendo.2022.786271
PMid:35242106 PMCid:PMC8886718
Neumann K, Griesinger G. Is oxytocin receptor antagonist administration around embryo transfer associated with IVF treatment success A systematic review and metaanalysis. Reproductive biomedicine online. 2021;43(6):98394.
https://doi.org/10.1016/j.rbmo.2021.08.020
PMid:34686417
Cera N, Pinto J, Pignatelli D. The role of oxytocin in polycystic ovary syndrome: A systematic review. Current Issues in Molecular Biology. 2024;46(6):522341.
https://doi.org/10.3390/cimb46060313
PMid:38920985 PMCid:PMC11201948
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